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The protein encoded by PNPLA3 is a triacylglycerol lipase that mediates triacylglycerol hydrolysis in adipocytes. Additionally we are shipping PNPLA3 Kits (12) and PNPLA3 Proteins (7) and many more products for this protein.
Showing 10 out of 86 products:
Human Polyclonal PNPLA3 Primary Antibody for EIA, WB - ABIN954228
Santoro, Kursawe, DAdamo, Dykas, Zhang, Bale, Calí, Narayan, Shaw, Pierpont, Savoye, Lartaud, Eldrich, Cushman, Zhao, Shulman, Caprio: A common variant in the patatin-like phospholipase 3 gene (PNPLA3) is associated with fatty liver disease in obese children and adolescents. in Hepatology (Baltimore, Md.) 2010
Show all 3 references for ABIN954228
Human Polyclonal PNPLA3 Primary Antibody for IHC, ELISA - ABIN361184
Kumari, Schoiswohl, Chitraju, Paar, Cornaciu, Rangrez, Wongsiriroj, Nagy, Ivanova, Scott, Knittelfelder, Rechberger, Birner-Gruenberger, Eder, Brown, Haemmerle, Oberer, Lass, Kershaw, Zimmermann et al.: Adiponutrin functions as a nutritionally regulated lysophosphatidic acid acyltransferase. ... in Cell metabolism 2012
Show all 2 references for ABIN361184
Dog (Canine) Polyclonal PNPLA3 Primary Antibody for EIA, IHC (p) - ABIN375148
Steinberg, Kemp, Watt: Adipocyte triglyceride lipase expression in human obesity. in American journal of physiology. Endocrinology and metabolism 2007
Human Polyclonal PNPLA3 Primary Antibody for IHC, WB - ABIN2783569
Wilson, Gardner, Lambie, Commans, Crowther: Characterization of the human patatin-like phospholipase family. in Journal of lipid research 2006
This study investigates the association between PNPLA3 rs738409 with health services utilization in a general population. PNPLA3 rs738409 was associated with the number of outpatient visits, hospitalization, and inpatient days.
Treating liver fat and serum triglyceride levels in NAFLD, effects of PNPLA3 and TM6SF2 genotypes: effect of Omacor administration.
As the HepG2 cell line harbors the I148M mutation in homozygous state it is hypothesized that this should represent an ideal model system for PNPLA3 biology.
The PPARGC1A (show PPARGC1A Antibodies) rs8192678 GA/AA genotype and the PNPLA3 rs738409 GG genotype had an additive effect on NASH (show SAMSN1 Antibodies) in severely obese Taiwanese patients.
PNPLA3 genetic variants and BMI played important roles in hepatic steatosis among Asian chronic hepatitis C patients.
rs2294918 E434K decreased PNPLA3 expression, lessening the effect of the I148M variant on predisposition to steatosis and liver damage
analysis of PNPLA3 (rs738409) and IL28B (show IL28B Antibodies) (rs12979860) SNPs in HIV/HCV coinfected patients reveals no impact on liver disease or treatment response
rs738409 in PNPLA3 is an important risk locus for alcohol-related cirrhosis.
Data show that the G allele of PNPLA3 protein single nucleotide polymorphism rs738409 and weight gain had a joint effect on the risk of non-alcoholic fatty liver disease (NAFLD (show TSC2 Antibodies)) in the normal weight and the overweight individuals.
PNPLA3 mRNA levels in the liver of the same section of a biopsy specimen used for genomic DNA preparation were lower in patients with advanced NAFLD (show TSC2 Antibodies) compared with those with mild NAFLD (show TSC2 Antibodies) and correlated inversely with CpG99 methylation in liver DNA.
Neither ablation nor overexpression of wild-type PNPLA3 affects liver fat content in mice, whereas hepatic overexpression of the human 148M transgene causes steatosis.
PNPLA3 plays a role in remodeling TAG in lipid droplets, as they accumulate in response to food intake
adiponutrin/PNPLA3 is regulated by two key factors of the glycolytic and lipogenic pathways, raising the question of its implication in the metabolism of carbohydrates and lipids
data argue against a role for Pnpla3 loss-of-function in fatty liver disease or metabolic syndrome in mice.
Loss of Pnpla3 does not cause fatty liver, liver enzyme elevation, or insulin (show INS Antibodies) resistance in mice.
Microarray-based gene profiling showed that the expression level of PNPLA3 in hepatocytes is correlated with that of genes associated with the lipogenic pathway such as ME1 (show ME1 Antibodies), SPOT14 (show THRSP Antibodies), and SCD1 (show SCD Antibodies).
data suggest that murine ATGL (show PNPLA2 Antibodies) but not adiponutrin contributes to net adipocyte lipolysis and that ATGL (show PNPLA2 Antibodies) and adiponutrin are oppositely regulated by insulin (show INS Antibodies) both in vitro and in vivo
The protein encoded by this gene is a triacylglycerol lipase that mediates triacylglycerol hydrolysis in adipocytes. The encoded protein, which appears to be membrane bound, may be involved in the balance of energy usage/storage in adipocytes.
, calcium-independent phospholipase A2-epsilon
, patatin-like phospholipase domain-containing protein 3