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Patatin-Like phospholipase Domain Containing 6 Proteins (PNPLA6)

PNPLA6 encodes a phospholipase that deacetylates intracellular phosphatidylcholine to produce glycerophosphocholine. Additionally we are shipping Patatin-Like phospholipase Domain Containing 6 Antibodies (71) and Patatin-Like phospholipase Domain Containing 6 Kits (7) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
PNPLA6 4907 P21589
PNPLA6 50767 Q3TRM4
Rat PNPLA6 PNPLA6 360753  
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Top Patatin-Like phospholipase Domain Containing 6 Proteins at antibodies-online.com

Showing 6 out of 6 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 69 to 74 Days
$9,050.32
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 69 to 74 Days
$12,906.52
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 49 to 54 Days
$13,567.94
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 49 to 54 Days
$13,567.94
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

PNPLA6 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
, ,
Mouse (Murine) ,
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More Proteins for Patatin-Like phospholipase Domain Containing 6 (PNPLA6) Interaction Partners

Fruit Fly (Drosophila melanogaster) Patatin-Like phospholipase Domain Containing 6 (PNPLA6) interaction partners

  1. inducible, neuron-specific expression of full-length human wildtype NTE reduces vacuole formation and substantially rescues mobility.

  2. OP-modified SWS cannot release PKA-C3 and the resulting loss of PKA-C3 activity plays a crucial role in developing the delayed symptoms of organophosphate-induced delayed neuropathy but not in the acute toxicity

Human Patatin-Like phospholipase Domain Containing 6 (PNPLA6) interaction partners

  1. CD73 promotes the growth of human colorectal cancer cells through EGFR (show EGFR Proteins) and the b-catenin/cyclin D1 (show CCND1 Proteins) signaling pathway. CD73 may be used as a valuable biomarker of colorectal cancer.

  2. The NT5E (show NT5E Proteins) gene is involved in both intrinsic and acquired resistance to platinum-based drugs in ovarian cancer. [meta-analysis]

  3. report on a Chinese family with CALJA and novel compound heterozygous mutations (c.1360G>A (p.Gly454Arg) and c.1387C>T (p.Arg463X)) in NT5E (show NT5E Proteins)

  4. inducible, neuron-specific expression of full-length human wildtype NTE reduces vacuole formation and substantially rescues mobility.

  5. Eight mutations in six families with Oliver-McFarlane or Laurence-Moon syndrome were identified in the PNPLA6 gene, which encodes neuropathy target esterase.

  6. role of CD73 and CD39 (show ENTPD1 Proteins) ectonucleotidases in T cell differentiation

  7. PNPLA6 has a role in photoreceptor survival; its mutations are linked to photoreceptor degeneration and various forms of childhood blindness

  8. Expression of NPP1 (show ENPP1 Proteins) and 5'-nucleotidase (show NT5E Proteins) by valve interstitial cells promotes the mineralization of the aortic valve through A2aR (show ADORA2A Proteins) and a cAMP/PKA/CREB (show CREB1 Proteins) pathway.

  9. we found a novel compound heterozygous mutation and a novel homozygous one in the PNPLA6 gene in two Japanese patients with BNS.

  10. Data confirm PNPLA6 mutations as the leading cause of Boucher-Neuhauser syndrome and suggest inquiring about a history of hypogonadism or visual changes in patients presenting with late-onset gait ataxia (show USP14 Proteins).

Mouse (Murine) Patatin-Like phospholipase Domain Containing 6 (PNPLA6) interaction partners

  1. the expression of CaMKIIalpha and pCREB exhibits a significant increase in cortex and hippocampus after treatment with PFOS, compared with the control.

  2. NTE has a role in neural development and in the neurodegeneration induced by organophosphate compounds in mice

  3. mouse brain neuropathy target esterase is a lysophospholipase

  4. impairment of vasculogenesis in the yolk sacs and embryos of null mutant conceptuses suggested that NTE is required for normal blood vessel development

  5. Increase of neuropathy target esterase (NTE) expression contributes to increased production and accumulation of glycerophosphocholine in mammalian renal cells in tissue culture and in vivo.

  6. We conclude that spongiform pathology in conditional NTE knockout mice is not mediated by PrPc (show PRNP Proteins), and that tubulovesicular inclusions can be seen in spongiform encephalopathy of other etiologies and are not pathognomonic of prion (show PRNP Proteins) disease

Patatin-Like phospholipase Domain Containing 6 (PNPLA6) Protein Profile

Protein Summary

This gene encodes a phospholipase that deacetylates intracellular phosphatidylcholine to produce glycerophosphocholine. It is thought to function in neurite outgrowth and process elongation during neuronal differentiation. The protein is anchored to the cytoplasmic face of the endoplasmic reticulum in both neurons and non-neuronal cells. Mutations in this gene result in autosomal recessive spastic paraplegia, and the protein is the target for neurodegeneration induced by organophosphorus compounds and chemical warfare agents. Multiple transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with PNPLA6

  • swiss cheese (sws)
  • 5'-nucleotidase, ecto (CD73) (NT5E)
  • patatin-like phospholipase domain containing 6 (pnpla6)
  • patatin-like phospholipase domain containing 6 (PNPLA6)
  • patatin-like phospholipase domain containing 6 (Pnpla6)
  • AI661849 protein
  • CALJA protein
  • CD73 protein
  • CG2212 protein
  • Dmel\\CG2212 protein
  • E5NT protein
  • eN protein
  • eNT protein
  • iPLA2delta protein
  • MSws protein
  • NT protein
  • NT5 protein
  • Nte protein
  • NTEMND protein
  • olfE protein
  • RGD1564611 protein
  • SPG39 protein
  • sws protein
  • wu:fy20f06 protein

Protein level used designations for PNPLA6

CG2212-PA , CG2212-PB , CG2212-PC , olfactory E , olfactory-E , swiss-cheese , swisscheese , sws-PA , sws-PB , sws-PC , 5'-NT , 5'-nucleotidase , Purine 5-Prime-Nucleotidase , ecto-5'-nucleotidase , nte , neuropathy target esterase , patatin-like phospholipase domain-containing protein 6 , Swiss cheese , Swiss-cheese

GENE ID SPECIES
31716 Drosophila melanogaster
4907 Homo sapiens
386860 Danio rerio
10908 Homo sapiens
50767 Mus musculus
425396 Gallus gallus
484993 Canis lupus familiaris
100524423 Sus scrofa
767822 Bos taurus
360753 Rattus norvegicus
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