Patatin-Like phospholipase Domain Containing 1 Proteins (PNPLA1)

The protein encoded by PNPLA1 belongs to the patatin-like phospholipase (PNPLA) family, which is characterized by the presence of a highly conserved patatin domain. Additionally we are shipping PNPLA1 Antibodies (38) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
PNPLA1 285848 Q8N8W4
PNPLA1 433091 Q3V1D5
Rat PNPLA1 PNPLA1 361812  
How to order from antibodies-online
  • +1 877 302 8632
  • +1 888 205 9894 (toll-free)
  • Order online
  • orders@antibodies-online.com

Top PNPLA1 Proteins at antibodies-online.com

Showing 2 out of 2 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
$7,759.50
Details
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
$7,759.50
Details

PNPLA1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human

Mouse (Murine)

More Proteins for Patatin-Like phospholipase Domain Containing 1 (PNPLA1) Interaction Partners

Human Patatin-Like phospholipase Domain Containing 1 (PNPLA1) interaction partners

  1. analysis of distinct and previously unreported mutations in the PNPLA1 gene in nine extended consanguineous families with autosomal recessive congenital ichthyosis (show LBR Proteins)

  2. an essential role of PNPLA1 in the synthesis of omega-O-AcylCers in human and murine skin.

  3. the variant identified will expand the spectrum of mutations in the PNPLA1 gene, provides more evidence for lack of genotype-phenotype correlation and clinical variability in PNPLA1 and underscores its role in causing autosomal recessive congenital ichthyosis (show LBR Proteins)

  4. Letter: novel missense PNPLA1 variant causing autosomal recessive congenital ichthyosis (show LBR Proteins) in a Pakistani family.

  5. Results show that PNPLA1 missense mutations observed in this European family affect the patanin-like domain

  6. One missense and one nonsense mutation in the catalytic domain of human PNPLA1 were found in six individuals with autosomal recessive congenital ichthyoses from two families.

  7. PNPLA1 exhibited a modest effect on obesity

Mouse (Murine) Patatin-Like phospholipase Domain Containing 1 (PNPLA1) interaction partners

  1. an essential role of PNPLA1 in the synthesis of omega-O-AcylCers in human and murine skin.

  2. results indicate PNPLA1 is a skin-specific and membrane-associated protein (show PDZK1IP1 Proteins), suggesting that it may mainly play a role in the skin

PNPLA1 Protein Profile

Protein Summary

The protein encoded by this gene belongs to the patatin-like phospholipase (PNPLA) family, which is characterized by the presence of a highly conserved patatin domain. PNPLA family members have diverse lipolytic and acyltransferase activities, and are key elements in lipid metabolism. While other members of this family have been well characterized, the function of this gene remained an enigma. However, recent studies show that this gene is expressed in the skin epidermal keratinocytes, and has a role in glycerophospholipid metabolism in the cutaneous barrier. Consistent with these observations, mutations in this gene are associated with ichthyosis in human (autosomal recessive congenital ichthyoses, ARCI) and dog. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with PNPLA1

  • patatin-like phospholipase domain containing 1 (PNPLA1)
  • patatin-like phospholipase domain containing 1 (Pnpla1)
  • ARCI10 protein
  • dJ50J22.1 protein

Protein level used designations for PNPLA1

patatin-like phospholipase domain-containing protein 1

GENE ID SPECIES
285848 Homo sapiens
433091 Mus musculus
361812 Rattus norvegicus
481763 Canis lupus familiaris
Selected quality suppliers for PNPLA1 Proteins (PNPLA1)
Did you look for something else?