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E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Additionally we are shipping Pellino Homolog 1 (Drosophila) Kits (5) and Pellino Homolog 1 (Drosophila) Proteins (5) and many more products for this protein.
Showing 10 out of 59 products:
Human Polyclonal PELI1 Primary Antibody for EIA, WB - ABIN1450038
Moynagh: The Pellino family: IRAK E3 ligases with emerging roles in innate immune signalling. in Trends in immunology 2009
The nonredundant role of Pellino1 in immune receptor signaling is in part due (show IRAK1 Antibodies)to its different substrate specificity.
Pellino1 interacts with the transcription factor Deformed Epidermal Autoregulatory Factor 1 (DEAF1 (show DEAF1 Antibodies)).
Peli1 is a microglia-specific mediator of autoimmune neuroinflammation that works by regulating Traf3 (show TRAF3 Antibodies) degradation
These results demonstrate that the ligands that signal via MyD88 (show MYD88 Antibodies) do not always employ the same protein kinase (show CDK7 Antibodies) to activate Pellino 1 and show that the activiation of NF-kappaB (show NFKB1 Antibodies) and mitogen-activated protein kinases.
Peli1 as a critical factor in the maintenance of peripheral T cell tolerance and demonstrate a previously unknown mechanism of c-Rel (show NFkBP65 Antibodies) regulation.
Pellino-1 protein may have a cellular function distinct from previously identified functions.
IKKepsilon (show IKBKE Antibodies)/TBK1 (show TBK1 Antibodies) mediate the activation of Pellino 1's E3 ligase activity, as well as inducing the transcription of its gene and protein expression in response to TLR3 (show TLR3 Antibodies) and TLR4 (show TLR4 Antibodies) agonists.
miR (show MLXIP Antibodies)-21 expression was upregulated during early stages of liver regeneration. Targeting of Peli1 by miR (show MLXIP Antibodies)-21 could potentially provide the basis for a negative feedback cycle regulating NF-kappaB (show NFKB1 Antibodies) signaling.
Peli1 is a ubiquitin ligase (show RNF123 Antibodies) needed for the transmission of TRIF (show RNF138 Antibodies)-dependent TLR signals.
The study results in the Chinese Han population showed that PELI1 is a member of a constellation of genetic factors that may contribute to the pathogenesis of systemic lupus erythematosus.
Increased PELI1 expression and subsequent induction of BCL6 (show BCL6 Antibodies) promotes lymphomagenesis.
Peptide PEL1 derived from the interleukin-1 receptor-associated kinase (IRAK)1 (show IRAK1 Antibodies)-binding motif reveals a distinct phosphothreonine peptide binding preference.
GWAS study found two new SNPs associated with nickel dermatitis; SNPs are located in the NTN4 and PELI1 genes
incomplete KD, IVIG nonresponsiveness, long febrile days, and the rs7604693 genetic variant in the PELI1 gene are major risk factors for the development of CALs (show CA8 Antibodies)
role in interleukin-1-mediated signalling through interaction with interleukin-1 receptor-associated kinase 4 (show IRAK4 Antibodies)-IRAK (show IRAK1 Antibodies)-tumor necrosis factor (show TNF Antibodies) receptor-associated factor 6 complex
Smad6 (show SMAD6 Antibodies) bound to Pellino-1 promoted TGF-beta (show TGFB1 Antibodies)-mediated anti-inflammatory effects.
kinase-inactive IRAK (show IRAK1 Antibodies) proteins can associate with Pellino proteins, thus excluding the possibility that their inability to regulate Pellino degradation is due to lack of association with the Pellino proteins
E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Involved in the TLR and IL-1 signaling pathways via interaction with the complex containing IRAK kinases and TRAF6. Mediates 'Lys-63'-linked polyubiquitination of IRAK1 allowing subsequent NF-kappa-B activation (By similarity).
E3 ubiquitin-protein ligase pellino homolog 1
, protein pellino homolog 1
, pellino homolog 1
, pellino-related intracellular-signaling molecule
, pellino 1
, pellino protein