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PELO encodes a protein which contains a conserved nuclear localization signal. Additionally we are shipping PELO Antibodies (35) and PELO Proteins (9) and many more products for this protein.
Human Pelota compensated for Dom34 functions in quality control of nonstop (show USP22 ELISA Kits) mRNA in yeast.
PELO is a novel regulator of HER-signalling.
The non-stop (show USP22 ELISA Kits) decay mechanism exists in mammalian cells and involves Hbs1 (show HBS1L ELISA Kits), Dom34, and the exosome-Ski (show SKI ELISA Kits) complex.
Pelota/Hbs1 (show HBS1L ELISA Kits) induced dissociation of elongation complexes from ribosomes and release of peptidyl-tRNA, but only in the presence of ABCE1 (show ABCE1 ELISA Kits).
PELO is subcellularly localized at the actin cytoskeleton, interacts with HAX1 (show HAX1 ELISA Kits), EIF3G (show EIF3G ELISA Kits) and SRPX (show SRPX ELISA Kits) proteins and that this interaction occurs at the cytoskeleton; this interaction may facilitate PELO to detect and degrade aberrant mRNAs.
thrombopoietin (show THPO ELISA Kits)-induced in vitro differentiation of primary human cord blood mononuclear cells into megakaryocytes, we observed rapid, progressive CpG methylation of ITGA1 (show ITGA1 ELISA Kits), but not PELO or ITGA2 (show ITGA2 ELISA Kits).
increased activity of the PI3K/AKT (show AKT1 ELISA Kits) signaling pathway in Pelo-deficient skin might conflict with the dephosphorylation of profilaggrin (show FLG ELISA Kits) and thereby affect its proper processing into filaggrin (show FLG ELISA Kits) monomers and ultimately the epidermal differentiation
These results suggest that PELO negatively regulates the PI3K/AKT (show AKT1 ELISA Kits) pathway and that the enhanced activity of PI3K/AKT (show AKT1 ELISA Kits) and subsequent FOXO1 (show FOXO1 ELISA Kits) inhibition are responsible for the impaired development of spermatogonial stem cells in mutant testes.
Results indicate that PELO plays an important role in the establishment of pluripotency and differentiation of ESCs into ExEn lineage through activation of BMP signaling.
these results not only define GTPBP2 (show GBP2 ELISA Kits) as a ribosome rescue factor but also unmask the disease potential of mutations in nuclear-encoded tRNA genes.
Pelo is required for the maintenance of genomic stability
This gene encodes a protein which contains a conserved nuclear localization signal. The encoded protein may have a role in spermatogenesis, cell cycle control, and in meiotic cell division.
protein pelota homolog