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PELO encodes a protein which contains a conserved nuclear localization signal. Additionally we are shipping PELO Antibodies (35) and many more products for this protein.
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Induction of ribosome rescue factors PELO and HBS1L is required to support protein synthesis when ABCE1 levels fall in platelets, including for hemoglobin production during blood cell development.
Human Pelota compensated for Dom34 functions in quality control of nonstop (show USP22 Proteins) mRNA in yeast.
PELO is a novel regulator of HER-signalling.
The non-stop (show USP22 Proteins) decay mechanism exists in mammalian cells and involves Hbs1 (show HBS1L Proteins), Dom34, and the exosome-Ski (show SKI Proteins) complex.
Pelota/Hbs1 (show HBS1L Proteins) induced dissociation of elongation complexes from ribosomes and release of peptidyl-tRNA, but only in the presence of ABCE1 (show ABCE1 Proteins).
PELO is subcellularly localized at the actin cytoskeleton, interacts with HAX1 (show HAX1 Proteins), EIF3G and SRPX (show SRPX Proteins) proteins and that this interaction occurs at the cytoskeleton; this interaction may facilitate PELO to detect and degrade aberrant mRNAs.
thrombopoietin (show THPO Proteins)-induced in vitro differentiation of primary human cord blood mononuclear cells into megakaryocytes, we observed rapid, progressive CpG methylation of ITGA1 (show ITGA1 Proteins), but not PELO or ITGA2 (show ITGA2 Proteins).
increased activity of the PI3K/AKT (show AKT1 Proteins) signaling pathway in Pelo-deficient skin might conflict with the dephosphorylation of profilaggrin (show FLG Proteins) and thereby affect its proper processing into filaggrin (show FLG Proteins) monomers and ultimately the epidermal differentiation
These results suggest that PELO negatively regulates the PI3K/AKT (show AKT1 Proteins) pathway and that the enhanced activity of PI3K/AKT (show AKT1 Proteins) and subsequent FOXO1 (show FOXO1 Proteins) inhibition are responsible for the impaired development of spermatogonial stem cells in mutant testes.
Results indicate that PELO plays an important role in the establishment of pluripotency and differentiation of ESCs into ExEn lineage through activation of BMP signaling.
these results not only define GTPBP2 (show GBP2 Proteins) as a ribosome rescue factor but also unmask the disease potential of mutations in nuclear-encoded tRNA genes.
Pelo is required for the maintenance of genomic stability
This gene encodes a protein which contains a conserved nuclear localization signal. The encoded protein may have a role in spermatogenesis, cell cycle control, and in meiotic cell division.
protein pelota homolog