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PGC encodes an aspartic proteinase that belongs to the peptidase family A1. Additionally we are shipping PGC Antibodies (158) and PGC Kits (49) and many more products for this protein.
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Human PGC Protein expressed in Human Cells - ABIN2005019
Moore, Sielecki, Chernaia, Tarasova, James: Crystal and molecular structures of human progastricsin at 1.62 A resolution. in Journal of molecular biology 1995
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Rat (Rattus) PGC Protein expressed in Human Cells - ABIN2009149
Khan, Cherney, Tarasova, James: Structural characterization of activation 'intermediate 2' on the pathway to human gastricsin. in Nature structural biology 1998
Show all 2 references for ABIN2009149
Results suggest that rs9471643 CG and rs6458238 AG/AA genotypes have important roles in up-regulating PGC expression, which may partially explain why individuals with these favorable genotypes have decreased risks of getting gastric cancer.
Data show that SNP interactions among H. pylori-related genes PGC, PTPN11 (show PTPN11 Proteins), and IL1B (show IL1B Proteins), are associated with susceptibility to gastric carcinogenesis.
Serum pepsinogens I (PGI (show BGN Proteins)) and II (PGII (show DCN Proteins)), gastrin (show GAST Proteins) 17 (G-17), and antibodies against whole H. pylori, or cytotoxin-associated gene A (CagA (show S100A8 Proteins)) antigen among 309 consecutive patients, were measured.
The results highlight an important role of PGC rs3789210 and rs6939861 in altering susceptibility to atrophic gastritis and/or gastric cancer.
Pepsinogen II is a good marker of corpus morphological changes before and after H. pylori eradication.
High serum Pepsinogen II level is associ9ated with the progression of gastric precancerous lesions.
An interaction effect of pri-let-7a-1 rs10739971 polymorphism with ERCC6 (show ERCC6 Proteins) rs1917799 polymorphism was observed for the risk of gastric cancer.
Pepsin and pepsinogen in middle ear effusion are probably caused by LPR (show FAS Proteins) and may be involved in the pathogenesis of OME.
High serum pepsinogen II is associated with gastric cancer development and activity of Helicobacter pylori-associated chronic gastritis.
Levels of pepsinogen/pepsin A and C are higher in the mouth swabs of infants with clinical gastroesophageal reflux.
This gene encodes an aspartic proteinase that belongs to the peptidase family A1. The encoded protein is a digestive enzyme that is produced in the stomach and constitutes a major component of the gastric mucosa. This protein is also secreted into the serum. This protein is synthesized as an inactive zymogen that includes a highly basic prosegment. This enzyme is converted into its active mature form at low pH by sequential cleavage of the prosegment that is carried out by the enzyme itself. Polymorphisms in this gene are associated with susceptibility to gastric cancers. Serum levels of this enzyme are used as a biomarker for certain gastric diseases including Helicobacter pylori related gastritis. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 1.
, pepsinogen C
, pepsin C
, pepsinogen group II
, urinary pepsinogen 1
, Urinary pepsinogen 1