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Pepsinogen C Proteins (PGC)

PGC encodes an aspartic proteinase that belongs to the peptidase family A1. Additionally we are shipping PGC Antibodies (157) and PGC Kits (49) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
PGC 5225 P20142
PGC 109820 Q9D7R7
PGC 24864 P04073
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Top PGC Proteins at antibodies-online.com

Showing 10 out of 19 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Human Cells Human His tag 10 μg Log in to see 16 Days
$250.80
Details
HOST_Human Cells Rat His tag 10 μg Log in to see 16 Days
$250.80
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 11 to 13 Days
$492.80
Details
HOST_Escherichia coli (E. coli) Rat His tag 100 μg Log in to see 11 to 13 Days
$792.00
Details
HOST_Escherichia coli (E. coli) Human His tag 50 μg Log in to see 16 Days
$382.80
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Callithrix jacchus His tag   1 mg Log in to see 56 to 66 Days
$2,887.50
Details
Yeast Rabbit His tag   1 mg Log in to see 56 to 66 Days
$2,887.50
Details

PGC Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
,
Mouse (Murine)

Rat (Rattus) , ,

Top referenced PGC Proteins

  1. Human PGC Protein expressed in Human Cells - ABIN2005019 : Moore, Sielecki, Chernaia, Tarasova, James: Crystal and molecular structures of human progastricsin at 1.62 A resolution. in Journal of molecular biology 1995 (PubMed)
    Show all 2 references for ABIN2005019

  2. Rat (Rattus) PGC Protein expressed in Human Cells - ABIN2009149 : Khan, Cherney, Tarasova, James: Structural characterization of activation 'intermediate 2' on the pathway to human gastricsin. in Nature structural biology 1998 (PubMed)
    Show all 2 references for ABIN2009149

More Proteins for Pepsinogen C (PGC) Interaction Partners

Human Pepsinogen C (PGC) interaction partners

  1. Results suggest that rs9471643 CG and rs6458238 AG/AA genotypes have important roles in up-regulating PGC expression, which may partially explain why individuals with these favorable genotypes have decreased risks of getting gastric cancer.

  2. Data show that SNP interactions among H. pylori-related genes PGC, PTPN11 (show PTPN11 Proteins), and IL1B (show IL1B Proteins), are associated with susceptibility to gastric carcinogenesis.

  3. Serum pepsinogens I (PGI (show BGN Proteins)) and II (PGII (show DCN Proteins)), gastrin (show GAST Proteins) 17 (G-17), and antibodies against whole H. pylori, or cytotoxin-associated gene A (CagA (show S100A8 Proteins)) antigen among 309 consecutive patients, were measured.

  4. The results highlight an important role of PGC rs3789210 and rs6939861 in altering susceptibility to atrophic gastritis and/or gastric cancer.

  5. Pepsinogen II is a good marker of corpus morphological changes before and after H. pylori eradication.

  6. High serum Pepsinogen II level is associ9ated with the progression of gastric precancerous lesions.

  7. An interaction effect of pri-let-7a-1 rs10739971 polymorphism with ERCC6 (show ERCC6 Proteins) rs1917799 polymorphism was observed for the risk of gastric cancer.

  8. Pepsin and pepsinogen in middle ear effusion are probably caused by LPR (show FAS Proteins) and may be involved in the pathogenesis of OME.

  9. High serum pepsinogen II is associated with gastric cancer development and activity of Helicobacter pylori-associated chronic gastritis.

  10. Levels of pepsinogen/pepsin A and C are higher in the mouth swabs of infants with clinical gastroesophageal reflux.

PGC Protein Profile

Protein Summary

This gene encodes an aspartic proteinase that belongs to the peptidase family A1. The encoded protein is a digestive enzyme that is produced in the stomach and constitutes a major component of the gastric mucosa. This protein is also secreted into the serum. This protein is synthesized as an inactive zymogen that includes a highly basic prosegment. This enzyme is converted into its active mature form at low pH by sequential cleavage of the prosegment that is carried out by the enzyme itself. Polymorphisms in this gene are associated with susceptibility to gastric cancers. Serum levels of this enzyme are used as a biomarker for certain gastric diseases including Helicobacter pylori related gastritis. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 1.

Gene names and symbols associated with Pepsinogen C Proteins (PGC)

  • progastricsin (pepsinogen C) (PGC)
  • progastricsin (pepsinogen C) (Pgc)
  • 2210410L06Rik protein
  • CPGC protein
  • Gastricsin protein
  • PEPC protein
  • Pg-1 protein
  • PG1 protein
  • PGC protein
  • PGII protein
  • PGNC protein
  • Upg-1 protein
  • Upg1 protein

Protein level used designations for Pepsinogen C Proteins (PGC)

gastricsin , pepsinogen C , pepsin C , pepsinogen group II , preprogastricsin , urinary pepsinogen 1 , Urinary pepsinogen 1 , gastricsin-like

GENE ID SPECIES
554184 Monodelphis domestica
5225 Homo sapiens
109820 Mus musculus
395690 Gallus gallus
24864 Rattus norvegicus
100009323 Oryctolagus cuniculus
100135598 Cavia porcellus
100404738 Callithrix jacchus
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