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Peptidase Inhibitor 3, Skin-Derived Proteins (PI3)

PI3 encodes an elastase-specific inhibitor that functions as an antimicrobial peptide against Gram-positive and Gram-negative bacteria. Additionally we are shipping Peptidase Inhibitor 3, Skin-Derived Antibodies (58) and Peptidase Inhibitor 3, Skin-Derived Kits (35) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
PI3 5266 P19957
Mouse PI3 PI3 20702 Q00896
Rat PI3 PI3 408230  
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Top Peptidase Inhibitor 3, Skin-Derived Proteins at antibodies-online.com

Showing 10 out of 11 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Human Cells Human His tag 10 μg Log in to see 16 Days
$250.80
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_HEK-293T Human His-DYKDDDDK-Strep II Tag 25 μg Log in to see 9 Days
$914.29
Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 11 to 13 Days
$774.40
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Wild boar His tag   1 mg Log in to see 56 to 66 Days
$2,165.17
Details
HOST_HEK293 Human His tag   50 μg Log in to see 5 Days
$522.50
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   50 μg Log in to see 3 to 4 Days
$388.93
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 9 to 19 Days
$952.01
Details
HOST_Human Human Un-conjugated   10 μg Log in to see 11 to 14 Days
$160.55
Details

PI3 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , , , ,
, ,

Top referenced Peptidase Inhibitor 3, Skin-Derived Proteins

  1. Human PI3 Protein expressed in Human Cells - ABIN2005095 : Tsunemi, Matsuura, Sakakibara, Katsube: Crystal structure of an elastase-specific inhibitor elafin complexed with porcine pancreatic elastase determined at 1.9 A resolution. in Biochemistry 1996 (PubMed)

More Proteins for Peptidase Inhibitor 3, Skin-Derived (PI3) Interaction Partners

Human Peptidase Inhibitor 3, Skin-Derived (PI3) interaction partners

  1. The expression of elafin in fallopian tubes of ectopic pregnancies is reduced.

  2. The elevations in cervical elafin and SLPI (show SLPI Proteins) expression in the women with preterm delivery might reflect the local response to the pathogen invasion into the cervix preceding preterm labor.

  3. PI3 expression was downregulated in 24% of DCIS and 83% of invasive breast tumors. PI3 was also downregulated in 33% of ovarian cystadenomas, 43% of borderline ovarian tumors, and 86% of invasive ovarian carcinomas.

  4. The imbalance between neutrophil elastase (show ELANE Proteins) and its inhibitors, such as elafin, presents an important therapeutic target in breast cancer.

  5. Higher urinary elafin levels are associated with an increased risk of micro- and macroalbuminuria, acute kidney injury and chronic kidney disease, and death after hematopoietic stem cell transplantation.

  6. cutaneous elafin does not seem to discriminate acute graft-versus-host disease from drug hypersensitivity rash lesions, but there may be an association between cutaneous elafin expression and poor prognosis for patients with cutaneous GVHD

  7. Data indicate that elafin overexpression is associated with poor overall survival.

  8. Low expression of elafin gene correlated with significantly reduced time to relapse, and when combined with high expression of elastase gene was associated with decreased survival in breast cancer patients

  9. Elafin has important roles in normal homoeostasis and at sites of inflammation. These roles include antiprotease and antimicrobial activity.

  10. Tubal epithelium from women with hydrosalpinx has lower levels of elafin expression.

Mouse (Murine) Peptidase Inhibitor 3, Skin-Derived (PI3) interaction partners

  1. Trappin-2 may therefore play an important role in innate recognition and clearance of pathogens during the very earliest stages of pulmonary infection.

Peptidase Inhibitor 3, Skin-Derived (PI3) Protein Profile

Protein Summary

This gene encodes an elastase-specific inhibitor that functions as an antimicrobial peptide against Gram-positive and Gram-negative bacteria. The protein contains a WAP-type four-disulfide core (WFDC) domain, and is thus a member of the WFDC domain family. Most WFDC gene members are localized to chromosome 20q12-q13 in two clusters: centromeric and telomeric. This gene belongs to the centromeric cluster. Expression of this gene is upgulated by bacterial lipopolysaccharides and cytokines.

Gene names and symbols associated with PI3

  • peptidase inhibitor 3, skin-derived (PI3)
  • elafin (TOM)
  • elafin (WAP-1)
  • peptidase inhibitor 3, skin-derived (SKALP) (PI3)
  • serine (or cysteine) peptidase inhibitor, clade A, member 1C (Serpina1c)
  • WAP four-disulfide core domain 15B (Wfdc15b)
  • cementoin protein
  • elafin protein
  • ESI protein
  • Pi3 protein
  • Pi6 protein
  • Serpina1c protein
  • Skalp protein
  • Spi1-3 protein
  • Spi1-6 protein
  • trappin-2 protein
  • Wap3 protein
  • Wfdc14 protein

Protein level used designations for PI3

elafin , elafin preproprotein , peptidase inhibitor 3, skin-derived (SKALP) , TRAPPIN-2 protein , trappin ovine homolog , elastase-specific inhibitor , skin-derived antileukoproteinase , peptidase inhibitor 3, skin-derived , protein WAP-1 , PI-3 , WAP four-disulfide core domain 14 , WAP four-disulfide core domain protein 14 , pre-elafin , protease inhibitor 3, skin-derived (SKALP) , protease inhibitor WAP3 , trappin-2 , alpha-1 protease inhibitor 3 , alpha-1 protease inhibitor 6 , alpha-1-antitrypsin 1-3 , alpha-1-antitrypsin 1-6 , apha-1 protease inhibitor 3 , serine (or cysteine) proteinase inhibitor, clade A, member 1c , serine protease inhibitor 1-3 , serine protease inhibitor 1-6 , serine protease inhibitor A1c , serpin A1c , WAP four-disulfide core domain protein 15B , WAP-type four-disulfide core 14 , protease inhibitor 3, skin-derived

GENE ID SPECIES
458276 Pan troglodytes
574237 Macaca mulatta
641305 Ovis aries
100137037 Pongo abelii
100137495 Papio anubis
100135056 Sus scrofa
5266 Homo sapiens
477241 Canis lupus familiaris
783871 Bos taurus
20702 Mus musculus
408230 Rattus norvegicus
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