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Peptidyl Arginine Deiminase, Type II Proteins (PADI2)

PADI2 encodes a member of the peptidyl arginine deiminase family of enzymes, which catalyze the post-translational deimination of proteins by converting arginine residues into citrullines in the presence of calcium ions. Additionally we are shipping Peptidyl Arginine Deiminase, Type II Antibodies (61) and Peptidyl Arginine Deiminase, Type II Kits (10) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
PADI2 11240 Q9Y2J8
PADI2 18600 Q08642
PADI2 29511 P20717
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Top Peptidyl Arginine Deiminase, Type II Proteins at antibodies-online.com

Showing 10 out of 10 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Escherichia coli (E. coli) Human His-SUMO Tag 50 μg Log in to see 21 to 26 Days
$341.00
Details
Yeast Human His tag 50 μg Log in to see 31 to 36 Days
$341.00
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$3,930.67
Details
HOST_Baculovirus infected Insect Cells Mouse GST tag   50 μg Log in to see 10 to 12 Days
$570.24
Details
Insect Cells Mouse GST tag   100 μg Log in to see 24 to 29 Days
$410.03
Details
Insect Cells Human GST tag   100 μg Log in to see 24 to 29 Days
$502.43
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

PADI2 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , , ,
, ,
Mouse (Murine) , ,
,
Rat (Rattus)

More Proteins for Peptidyl Arginine Deiminase, Type II (PADI2) Interaction Partners

Human Peptidyl Arginine Deiminase, Type II (PADI2) interaction partners

  1. We identified the presence of PADI3 (show PADI3 Proteins) mRNA expression in synovial tissue and PADI2 and PADI4 (show PADI4 Proteins) mRNA expressions in fibroblast-like synoviocytes from patients with rheumatoid arthritis.

  2. Protein arginine deiminase 2 binds six calcium ions in an ordered fashion.

  3. PAD2 activity was significantly higher in cell-free synovial fluid of rheumatoid arthritis patients compared to osteoarthritis patients.

  4. PAD2 activity was detected in synovial fluid samples from patients with rheumatoid arthritis.

  5. Report increased levels of extracellular PAD2 in the lungs of smokers.

  6. PADI2 and vimentin (show VIM Proteins) participate in the apoptotic mechanisms of activated T lymphocytes.

  7. these studies provide the first genetic evidence that PAD2 functions as an oncogene and suggest that PAD2 may promote tumor progression by enhancing inflammation within the tumor microenvironment.

  8. PAD2 appears to use a substrate-assisted mechanism of catalysis in which the positively charged substrate guanidinium depresses the pKa of the nucleophilic cysteine

  9. Data suggest peptidylarginine deiminase 2 (PAD2) as a possible biomarker in various inflammatory diseases.

  10. PAD2 and PAD4 (show PADI4 Proteins) have distinct substrate specificities.

Cow (Bovine) Peptidyl Arginine Deiminase, Type II (PADI2) interaction partners

Mouse (Murine) Peptidyl Arginine Deiminase, Type II (PADI2) interaction partners

  1. GPx7 (show GPX7 Proteins) is an unusual CysGPx catalyzing the peroxidatic cycle by a one Cys (show DNAJC5 Proteins) mechanism in which GSH and PDI (show PDIA3 Proteins) are alternative substrates.

  2. Results suggest that PADI2 may function as an important new biomarker for HER2/ERBB2 (show ERBB2 Proteins)+ tumors and that Cl-amidine represents a new candidate for breast cancer therapy.

  3. Activation of the P2X7 purinergic receptor (P2X7 (show P2RX7 Proteins)) by the inflammatory danger signal ATP induces PAD2 activity and robust protein citrullination in mast cells.

  4. different subcellular compartmentalization of PADi2 and citrullinated proteins may have different physiological roles in normal and neurodegenerative conditions

  5. PAD2 interacts with IKKgamma (show IKBKG Proteins) and suppresses NF-kappaB (show NFKB1 Proteins) activity.

  6. Results suggest that peptidylarginine deiminase 2-catalyzed citrullination is not essential to the development of experimental autoimmune encephalomyelitis.

  7. An increase in citrullinated proteins resulting from increased PAD2 and 4 is an important change in the pathogenesis of multiple sclerosis.

  8. This study suggests that accumulated citrullinated proteins and abnormal activation of PAD2 may function in the pathogenesis of prion (show PRNP Proteins) diseases and serve as potential therapeutic targets.

  9. elevated levels of the pro-inflammatory cytokine TNF-alpha and nuclear histone deimination support initiation of demyelination by increased PAD activity

Peptidyl Arginine Deiminase, Type II (PADI2) Protein Profile

Protein Summary

This gene encodes a member of the peptidyl arginine deiminase family of enzymes, which catalyze the post-translational deimination of proteins by converting arginine residues into citrullines in the presence of calcium ions. The family members have distinct substrate specificities and tissue-specific expression patterns. The type II enzyme is the most widely expressed family member. Known substrates for this enzyme include myelin basic protein in the central nervous system and vimentin in skeletal muscle and macrophages. This enzyme is thought to play a role in the onset and progression of neurodegenerative human disorders, including Alzheimer disease and multiple sclerosis, and it has also been implicated in glaucoma pathogenesis. This gene exists in a cluster with four other paralogous genes.

Gene names and symbols associated with PADI2

  • peptidyl arginine deiminase, type II (PADI2)
  • peptidyl arginine deiminase, type II (padi2)
  • peptidyl arginine deiminase, type II (LOC100357368)
  • peptidyl arginine deiminase, type II (Padi2)
  • mKIAA0994 protein
  • PAD-H19 protein
  • PAD2 protein
  • PADI2 protein
  • Pdi protein
  • Pdi2 protein

Protein level used designations for PADI2

peptidyl arginine deiminase, type II , protein-arginine deiminase type-2-like , peptidlyarginine deiminase type II , peptidylarginine deiminase II , protein arginine deiminase , protein-arginine deiminase type II , protein-arginine deiminase type-2 , peptidyl arginine deiminase, type 2 , PAD type II , peptidyl arginine deiminase, type II; PAD type II

GENE ID SPECIES
456527 Pan troglodytes
711044 Macaca mulatta
100050025 Equus caballus
100125112 Xenopus (Silurana) tropicalis
100357368 Oryctolagus cuniculus
100437331 Pongo abelii
100473552 Ailuropoda melanoleuca
11240 Homo sapiens
380061 Xenopus laevis
428172 Gallus gallus
617851 Bos taurus
18600 Mus musculus
29511 Rattus norvegicus
487414 Canis lupus familiaris
100621356 Sus scrofa
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