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Peptidyl Arginine Deiminase, Type III Proteins (PADI3)

PADI3 encodes a member of the peptidyl arginine deiminase family of enzymes, which catalyze the post-translational deimination of proteins by converting arginine residues into citrullines in the presence of calcium ions. Additionally we are shipping PADI3 Antibodies (11) and PADI3 Kits (3) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
PADI3 51702 Q9ULW8
PADI3 18601 Q9Z184
PADI3 29520 P70708
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Top PADI3 Proteins at antibodies-online.com

Showing 5 out of 6 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$3,927.00
Details
HOST_Baculovirus infected Insect Cells Human GST tag   50 μg Log in to see 10 to 12 Days
$570.24
Details

PADI3 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
,
Mouse (Murine)

Rat (Rattus)

More Proteins for Peptidyl Arginine Deiminase, Type III (PADI3) Interaction Partners

Human Peptidyl Arginine Deiminase, Type III (PADI3) interaction partners

  1. We identified the presence of PADI3 mRNA expression in synovial tissue and PADI2 (show PADI2 Proteins) and PADI4 (show PADI4 Proteins) mRNA expressions in fibroblast-like synoviocytes from patients with rheumatoid arthritis.

  2. The prevalence and extent of ILD was markedly higher among RA patients with anti-PAD3/4 cross-reactive antibodies, even after accounting for relevant confounders, particularly among ever smokers.

  3. Crystals of PAD3 obtained using polyethylene glycol 400 as a precipitant diffracted to 2.95 A resolution using synchrotron radiation

  4. peptidylarginine deiminase types 1 and 3 loci map to chromosomal band 1p36.13

  5. PAD1 (show PSMD14 Proteins) and 3 are able to modify filaggrin (show FLG Proteins)

  6. PAD3 is co-located with filaggrin (show FLG Proteins) within the filamentous matrix of the deeper corneocytes where the protein is deiminated.

  7. PADI3 expression is driven by Sp1/Sp3 and NF-Y binding to the promoter region

  8. cytoplasmic S100A3 within the cuticular layer is mostly co-localized with the type III isoform of peptidylarginine deiminase (PAD3)

  9. Peptidylarginine deiminase Intergenic Enhancer is a strong enhancer of the PADI3 promoter in Ca2 (show CA2 Proteins)+-differentiated epidermal keratinocytes, and requires bound

  10. These results reveal the molecular bases of the expression specificity of PADI1 (show PADI1 Proteins) and PADI3 during keratinocyte differentiation through a long-range enhancer and support a model of PADI gene regulation depending on c-Jun (show JUN Proteins)-JunD (show JUND Proteins) competition.

PADI3 Protein Profile

Protein Summary

This gene encodes a member of the peptidyl arginine deiminase family of enzymes, which catalyze the post-translational deimination of proteins by converting arginine residues into citrullines in the presence of calcium ions. The family members have distinct substrate specificities and tissue-specific expression patterns. The type III enzyme modulates hair structural proteins, such as filaggrin in the hair follicle and trichohyalin in the inner root sheath, during hair follicle formation. Together with the type I enzyme, this enzyme may also play a role in terminal differentiation of the epidermis. This gene exists in a cluster with four other paralogous genes.

Gene names and symbols associated with PADI3

  • peptidyl arginine deiminase, type III (PADI3)
  • peptidyl arginine deiminase, type III (LOC100350962)
  • peptidyl arginine deiminase, type III (Padi3)
  • AI507004 protein
  • cPAD3 protein
  • mKIAA4171 protein
  • PAD protein
  • Pad3 protein
  • PADI3 protein
  • Pdi3 protein

Protein level used designations for PADI3

peptidylarginine deiminase type III , protein-arginine deiminase type-3 , peptidyl arginine deiminase, type III , protein-arginine deiminase type-3-like , peptidylarginine deiminase III , protein-arginine deiminase type III , PAD type III , PROTEIN-ARGININE DEIMINASE TYPE III (PEPTIDYLARGININE DEIMINASE III) , peptidyl arginine deiminase, type 3

GENE ID SPECIES
395910 Gallus gallus
469178 Pan troglodytes
478216 Canis lupus familiaris
700560 Macaca mulatta
100017366 Monodelphis domestica
100049897 Equus caballus
100350962 Oryctolagus cuniculus
100415123 Callithrix jacchus
100436194 Pongo abelii
100474058 Ailuropoda melanoleuca
100524379 Sus scrofa
100596492 Nomascus leucogenys
51702 Homo sapiens
18601 Mus musculus
29520 Rattus norvegicus
443369 Ovis aries
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