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The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity). Additionally we are shipping Peptidyl-tRNA Hydrolase 2 Antibodies (86) and many more products for this protein.
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Human PTRH2 Protein expressed in Escherichia coli (E. coli) - ABIN667850
De Pereda, Waas, Jan, Ruoslahti, Schimmel, Pascual: Crystal structure of a human peptidyl-tRNA hydrolase reveals a new fold and suggests basis for a bifunctional activity. in The Journal of biological chemistry 2004
Show all 2 references for ABIN667850
Bit1 may be an important regulator in cell growth, apoptosis, migration and invasion of esophageal squamous cell carcinoma via targeting FAK (show PTK2 Proteins)-paxillin (show PXN Proteins) pathway.
these findings suggest a tumor suppressive role of the caspase-independent anoikis effector Bit1 in lung cancer.
Reduction of the Bit1 level in cytosol, regulated by E2 binding to ESR1 (show ESR1 Proteins), was mainly mediated through PI3K (show PIK3CA Proteins)/AKT (show AKT1 Proteins) pathways.
Bit1 plays pivotal roles in the development and progression of ESCC, and its biological functions in ESCC may be closely associated with AIF (show AIFM1 Proteins) and Bcl-2 (show BCL2 Proteins) levels.
TLE1 (show TLE1 Proteins) inhibits the Bit1 anoikis pathway by reducing the formation of the proapoptotic Bit1-AES (show AES Proteins) complex in part through sequestration of AES (show AES Proteins) in the nucleus.
Bit1 may be a useful pathological marker and a prognostic marker for serous papillary adenocarcinomas outcome.
Data indicate that the cell death domain (CDD) to the N-terminal 62 amino acids of Bit1 was more potent in killing cells than the full-length Bit1 protein when equivalent amounts of cDNA were transfected.
downregulation of Bit1 conferred cancer cells with enhanced anoikis resistance, adhesive and migratory properties in vitro
Bit-1 mediates integrin-dependent cell survival through activation of the NFkappaB pathway
Results identify Bit1, a mitochondrial protein (show COX6B2 Proteins) released into the cytoplasm during apoptosis that forms a complex with AES (show AES Proteins), a small Groucho/transducin (show GNAT1 Proteins)-like enhancer of split (TLE) protein
These results support an unanticipated yet essential role for Bit-1 in controlling myogenesis through regulation of Bcl-2 (show BCL2 Proteins).
downregulation of Bit1 specifically potentiated tumor metastasis in vivo
These studies establish the physiological significance of Bit1 activity and begin to delineate a Bit1 signaling pathway that acts through Erk (show EPHB2 Proteins) regulation.
The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity).
peptidyl-tRNA hydrolase 2
, PTH 2
, bcl-2 inhibitor of transcription 1
, peptidyl-tRNA hydrolase 2, mitochondrial
, Bcl-2 inhibitor of transcription