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anti-Peptidylglycine alpha-Amidating Monooxygenase (PAM) Antibodies

PAM encodes a multifunctional protein. Additionally we are shipping PAM Proteins (9) and PAM Kits (7) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
PAM 5066 P19021
PAM 18484 P97467
PAM 25508 P14925
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Top anti-PAM Antibodies at antibodies-online.com

Showing 10 out of 32 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-PAM Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:62500Positive Control: 721_B cell lysate 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Goat Un-conjugated WB 0.1 mg Log in to see 6 to 8 Days
$379.50
Details
Human Goat Un-conjugated ELISA, WB ABIN238682 (1µg/ml) staining of Human Kidney lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. 100 μg Log in to see 4 to 5 Days
$318.20
Details
Human Goat Un-conjugated ELISA, WB 0.1 mg Log in to see 2 to 3 Days
$433.13
Details
Human Rabbit Un-conjugated WB 50 μg Log in to see 8 to 10 Days
$551.83
Details
Human Rabbit Un-conjugated WB   100 μL Log in to see 8 to 10 Days
$383.17
Details
Human Rabbit Un-conjugated WB   100 μL Log in to see 8 to 10 Days
$383.17
Details
Human Rabbit Un-conjugated WB   100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Goat PE ELISA, WB   100 μL Log in to see 16 Days
$713.43
Details
Human Goat APC ELISA, WB   100 μL Log in to see 16 Days
$713.43
Details

PAM Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
Human , , ,
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Mouse (Murine)
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Rat (Rattus)
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Top referenced anti-PAM Antibodies

  1. Cow (Bovine) Polyclonal PAM Primary Antibody for WB - ABIN2781297 : Olsen, Blagoev, Gnad, Macek, Kumar, Mortensen, Mann: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. in Cell 2006 (PubMed)

  2. Human Polyclonal PAM Primary Antibody for ELISA, WB - ABIN238682 : Glauder, Ragg, Rauch, Engels: Human peptidylglycine alpha-amidating monooxygenase: cDNA, cloning and functional expression of a truncated form in COS cells. in Biochemical and biophysical research communications 1990 (PubMed)

More Antibodies against PAM Interaction Partners

Fruit Fly (Drosophila melanogaster) Peptidylglycine alpha-Amidating Monooxygenase (PAM) interaction partners

Human Peptidylglycine alpha-Amidating Monooxygenase (PAM) interaction partners

  1. PAM expression is increased in the secretory pathway of differentiated neurons.

  2. Oxygen Sensitivity of the Peptidylglycine alpha-Amidating Monooxygenase (PAM) in Neuroendocrine Cells

  3. Two missense variants in PAM, encoding p.Asp563Gly (frequency of 4.98%) and p.Ser539Trp (frequency of 0.65%), confer moderately higher risk of type 2 diabetes (OR = 1.23, P = 3.9 x 10(-10) and OR = 1.47, P = 1.7 x 10(-5), respectively)

  4. Detail the production of the catalytic core of human peptidylglycine alpha-hydroxylating monooxygenase (hPHMcc) in Escherichia coli possessing a N-terminal fusion to thioredoxin (Trx (show TXN Antibodies)).

  5. Data indicate that catalytic inactivation of PHM caused by pH changes is accompanied by structural change between two states of the protein involving strong Cu-S interaction that does not involve M314.

  6. nuclear retention of PAM mRNA is lost upon expressing the La proteins that lack a conserved nuclear retention element, suggesting a direct association between PAM mRNA and La protein in vivo

Mouse (Murine) Peptidylglycine alpha-Amidating Monooxygenase (PAM) interaction partners

  1. Oxygen Sensitivity of the Peptidylglycine alpha-Amidating Monooxygenase (PAM) in Neuroendocrine Cells

  2. Disruption of AP-1 (show JUN Antibodies)-dependent late endosomal trafficking diminishes the ability of PAM to retain copper and produce amidated peptides.

  3. deficits in PAM reversibly affect copper homeostasis, with behavioral and physiological consequences

  4. Reduced amygdalar expression of Atox-1 (show ATOX1 Antibodies) and Atp7a (show ATP7A Antibodies) in PAM heterozygous mice may lead to reduced synaptic Cu levels, contributing to the behavioral and neurochemical alterations seen in these mice.

  5. While glycine-extended reaction intermediates accumulated in the PAM(+/-) mice and reflected dietary copper availability, amidated products were far more prevalent under the conditions examined.

  6. Although the copper-dependent mechanisms through which the endocytic trafficking of PAM alters gene expression have not been elucidated in this review, the cytosolic fragment of PAM identified in pituitary and atrial nuclei is likely to play a key role.

  7. Cleavage of PAM releases a soluble CD fragment that localizes to the nucleus. Localization of PAM-CD to the nucleus was decreased when PAM-CD with phosphomimetic mutations was examined and when active Uhmk1 (show UHMK1 Antibodies) was simultaneously overexpressed.

  8. Altered copper homeostasis in PAM(+/-) mice suggested a role for PAM in the cell type specific regulation of copper metabolism.

  9. In 12-day-old (P12 (show CDK2AP1 Antibodies)) mouse pups derived from dams that began Cu deficiency on day 7 of gestation, there was a parallel reduction in brain PAM activity and protein of 40-50%.

  10. expression analysis of PHM in rats and in mouse cells

Cow (Bovine) Peptidylglycine alpha-Amidating Monooxygenase (PAM) interaction partners

PAM Antigen Profile

Protein Summary

This gene encodes a multifunctional protein. It has two enzymatically active domains with catalytic activities - peptidylglycine alpha-hydroxylating monooxygenase (PHM) and peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL). These catalytic domains work sequentially to catalyze neuroendocrine peptides to active alpha-amidated products. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene but some of their full length sequences are not yet known.

Gene names and symbols associated with PAM

  • Peptidylglycine-alpha-hydroxylating monooxygenase (Phm) antibody
  • peptidylglycine alpha-amidating monooxygenase (PAM) antibody
  • peptidylglycine alpha-amidating monooxygenase (CHLREDRAFT_150435) antibody
  • peptidylglycine alpha-amidating monooxygenase (sce7070) antibody
  • peptidylglycine alpha-amidating monooxygenase (pam) antibody
  • peptidylglycine alpha-amidating monooxygenase (Pam) antibody
  • CG3832 antibody
  • Dmel\\CG3832 antibody
  • dPHM antibody
  • PAL antibody
  • phm antibody

Protein level used designations for PAM

CG3832-PA , CG3832-PB , Phm-PA , Phm-PB , peptidyl gycine alpha hydroxylating monooxygenase , peptidylglycine alpha-hydroxylating monooxygenase , peptidylglycine-alpha-hydroxylating monooxygenase , peptidylglycine alpha-amidating monooxygenase , peptidyl-glycine alpha-amidating monooxygenase , peptidyl-glycine alpha-amidating monooxygenase-like , pancreatic peptidylglycine alpha-amidating monooxygenase , peptidyl alpha-amidating enzyme , peptidyl-alpha-hydroxyglycine alpha-amidating lyase , peptidylamidoglycolate lyase , peptidylglycine 2-hydroxylase , PEPTIDYL-GLYCINE ALPHA-AMIDATING MONOOXYGENASE PRECURSOR (PAM)

GENE ID SPECIES
37823 Drosophila melanogaster
427274 Gallus gallus
461974 Pan troglodytes
479145 Canis lupus familiaris
707733 Macaca mulatta
791244 Equus caballus
5723115 Chlamydomonas reinhardtii
5811519 Sorangium cellulosum So ce56
100030601 Monodelphis domestica
100170159 Xenopus (Silurana) tropicalis
100352005 Oryctolagus cuniculus
100396001 Callithrix jacchus
100449730 Pongo abelii
100484534 Ailuropoda melanoleuca
100526040 Sus scrofa
100562563 Anolis carolinensis
100603954 Nomascus leucogenys
5066 Homo sapiens
18484 Mus musculus
25508 Rattus norvegicus
280890 Bos taurus
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