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Peptidylprolyl Cis/trans Isomerase, NIMA-Interacting 1 Proteins (PIN1)

Peptidyl-prolyl cis/trans isomerases (PPIases) catalyze the cis/trans isomerization of peptidyl-prolyl peptide bonds. Additionally we are shipping Peptidylprolyl Cis/trans Isomerase, NIMA-Interacting 1 Antibodies (200) and Peptidylprolyl Cis/trans Isomerase, NIMA-Interacting 1 Kits (5) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
PIN1 241593  
PIN1 5300 Q13526
PIN1 298696  
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Top Peptidylprolyl Cis/trans Isomerase, NIMA-Interacting 1 Proteins at antibodies-online.com

Showing 10 out of 21 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human Un-conjugated 100 μg Log in to see 2 to 3 Days
$357.00
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 16 Days
$382.80
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Arabidopsis thaliana His tag   1 mg Log in to see 56 to 66 Days
$2,234.83
Details
Yeast REACT_Apple His tag   1 mg Log in to see 56 to 66 Days
$2,240.33
Details
Yeast Rhizopus oryzae His tag   1 mg Log in to see 56 to 66 Days
$2,330.17
Details
Yeast Cow His tag   1 mg Log in to see 56 to 66 Days
$2,370.50
Details
Yeast Macaca fascicularis His tag   1 mg Log in to see 56 to 66 Days
$2,370.50
Details

PIN1 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human , ,
,
Rat (Rattus)

Top referenced Peptidylprolyl Cis/trans Isomerase, NIMA-Interacting 1 Proteins

  1. Human PIN1 Protein expressed in Escherichia coli (E. coli) - ABIN2002501 : Joseph, Yeh, Swenson, Means, Winkler: The peptidyl-prolyl isomerase Pin1. in Progress in cell cycle research 2003 (PubMed)
    Show all 2 references for ABIN2002501

More Proteins for Peptidylprolyl Cis/trans Isomerase, NIMA-Interacting 1 (PIN1) Interaction Partners

Mouse (Murine) Peptidylprolyl Cis/trans Isomerase, NIMA-Interacting 1 (PIN1) interaction partners

  1. results revealed a pivotal role of Pin1 in regulation of alcohol-induced mouse cardiomyocytes apoptosis by promoting reactive oxygen species (ROS (show ROS1 Proteins)) accumulation and repressing eNOS (show NOS3 Proteins) expression, which could be potential therapeutic targets for ACM.

  2. diet containing high phosphate induces rapid renal fibrosis before a significant impact on renal function and Pin1 plays an important role in the fibrotic process.

  3. Pin1 is indispensable for Wnt3a (show WNT3A Proteins)-induced osteoblast differentiation.

  4. Pin1 regulates the osteogenic activity of Osterix (show SP7 Proteins).

  5. Pin1-dependent signaling represents a mechanism to modulate GABAergic transmission by regulating NL2 (show MMEL1 Proteins)/gephyrin (show GPHN Proteins) interaction.

  6. PIN1 regulates pulmonary effects of endotoxin and tumor necrosis factor-alpha (show TNF Proteins) in mice.

  7. Thus, Pin1 could be developed as a major therapeutic target in many skeletal diseases

  8. Results show that DLX5 (show DLX5 Proteins), p63 (show CKAP4 Proteins), Pin1 and FGF8 (show FGF8 Proteins) participate to the same time- and location-restricted regulatory loop essential for apical ectodermal ridge stratification, hence for normal patterning and skeletal morphogenesis of the limb buds.

  9. Pin1 induction during liver fibrosis is involved in hepatic stellate cell activation, TGFbeta1 (show TGFB1 Proteins) expression, and TGFbeta1 (show TGFB1 Proteins)-mediated fibrogenesis signalling.

  10. The identification of Pin1 as a factor involved in cell fusion contributes to the understanding of osteoclast-associated diseases, including osteoporosis, and opens new avenues for therapeutic targets.

Xenopus laevis Peptidylprolyl Cis/trans Isomerase, NIMA-Interacting 1 (PIN1) interaction partners

  1. Pin1 is an essential factor regulating CPEB degradation

  2. Pin1 binding is required for the inactivation of XeWee1B at M phase, presumably causing isomerization of the phospho-TP motif and thereby impairing the function of the Wee (show WEE1 Proteins)-box

Human Peptidylprolyl Cis/trans Isomerase, NIMA-Interacting 1 (PIN1) interaction partners

  1. the role of hydration in the structural integrity of Pin1

  2. Results indicate that PIN1 may be a valuable target to hit in cancer cells characterized by increased aggressive potential, overexpression of erbB (show EGFR Proteins) receptor family members, and defective p53 (show TP53 Proteins).

  3. Structural Analysis of the Pin1-CPEB1 (show CPEB1 Proteins) interaction and its potential role in CPEB1 (show CPEB1 Proteins) degradation has been described.

  4. Data show that Prolyl isomerase Pin1 is expressed in an epidermal growth factor receptor (EGFR (show EGFR Proteins))-mutant lung cancer tissue that has undergone partial epithelial-mesenchymal transition (EMT (show ITK Proteins)) and acquired resistance to EGFR (show EGFR Proteins) tyrosine kinase (show TXK Proteins) inhibitors (TKIs).

  5. Report shows that PIN1 binds to and stabilizes HIF-1alpha (show HIF1A Proteins), consequently enhancing the angiogenesis.

  6. This shows that Pin1 is implemented in maintaining the susceptibility to the genotoxic drugs by controlling P-gp (show ABCB4 Proteins) level as well as p53 (show TP53 Proteins)-dependent apoptosis and cell cycle signaling pathways.

  7. Activation of BAX (show BAX Proteins) through the concerted action of cytosolic p53 (show TP53 Proteins) and Pin1 may integrate cell stress signals to induce a direct apoptotic response.

  8. The roles of the three tryptophan residues (W11, W34 and W73)in maintaining the structure and the function of Pin1

  9. Expression of Pin1 was decreased at or above the Cd IC50 value and was inversely correlated with the level of phospho-Ser (show SIGLEC1 Proteins)-GSK3alphabeta in oral squamous cell carcinoma.

  10. ZBP-89 (show ZNF148 Proteins) attenuates HDAC3 (show HDAC3 Proteins) by increasing IkappaB degradation, dependent on Pin1 but independent of NF-Kappab (show NFKB1 Proteins)

Cow (Bovine) Peptidylprolyl Cis/trans Isomerase, NIMA-Interacting 1 (PIN1) interaction partners

  1. The data provide the first evidence that Pin 1 expression in the granulosa cells but not the theca cells changes during follicular development, and that FSH (show BRD2 Proteins) stimulate the expression of the Pin 1 gene.

Peptidylprolyl Cis/trans Isomerase, NIMA-Interacting 1 (PIN1) Protein Profile

Protein Summary

Peptidyl-prolyl cis/trans isomerases (PPIases) catalyze the cis/trans isomerization of peptidyl-prolyl peptide bonds. This gene encodes one of the PPIases, which specifically binds to phosphorylated ser/thr-pro motifs to catalytically regulate the post-phosphorylation conformation of its substrates. The conformational regulation catalyzed by this PPIase has a profound impact on key proteins involved in the regulation of cell growth, genotoxic and other stress responses, the immune response, induction and maintenance of pluripotency, germ cell development, neuronal differentiation, and survival. This enzyme also plays a key role in the pathogenesis of Alzheimer's disease and many cancers. Multiple alternatively spliced transcript variants have been found for this gene.

Gene names and symbols associated with PIN1

  • protein (peptidyl-prolyl cis/trans isomerase) NIMA-interacting 1, retrogene 1 (Pin1rt1)
  • peptidylprolyl cis/trans isomerase, NIMA-interacting 1 (pin1-b)
  • peptidylprolyl cis/trans isomerase, NIMA-interacting 1 (pin1)
  • peptidylprolyl cis/trans isomerase, NIMA-interacting 1 (pin1-a)
  • peptidylprolyl cis/trans isomerase, NIMA-interacting 1 (PIN1)
  • peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (ppiD)
  • peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PITG_11123)
  • peptidylprolyl cis/trans isomerase, NIMA-interacting 1 (Pin1)
  • protein (peptidyl-prolyl cis/trans isomerase) NIMA-interacting 1 (Pin1)
  • 0610025L01Rik protein
  • D9Bwg1161e protein
  • DOD protein
  • OTTMUSG00000014964 protein
  • pin1 protein
  • Pin1-ps1 protein
  • pin1a protein
  • pin1b protein
  • Pin1l protein
  • UBL5 protein

Protein level used designations for PIN1

peptidylprolyl cis/trans isomerase, NIMA-interacting 1 , peptidylprolyl cis/trans isomerase, NIMA-interacting 1, pseudogene 1 , prolyl isomerase Pin1 b , prolyl isomerase Pin1 , peptidylprolyl cis/trans isomerase, NIMA-interacting 1 b , protein (peptidylprolyl cis/trans isomerase) NIMA-interacting 1 , peptidylprolyl cis/trans isomerase, NIMA-interacting 1 a , peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 , PPIase Pin1 , protein (peptidyl-prolyl cis/trans isomerase) NIMA-interacting 1 , rotamase Pin1 , peptidyl-prolyl cis-trans isomerase Pin1

GENE ID SPECIES
241593 Mus musculus
399385 Xenopus laevis
493472 Xenopus (Silurana) tropicalis
503670 Xenopus laevis
711095 Macaca mulatta
745021 Pan troglodytes
5807350 Sorangium cellulosum So ce56
9476290 Phytophthora infestans T30-4
5300 Homo sapiens
484963 Canis lupus familiaris
298696 Rattus norvegicus
535470 Bos taurus
100512827 Sus scrofa
23988 Mus musculus
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