Peptidylprolyl Cis/trans Isomerase, NIMA-Interacting 1 (PIN1) ELISA Kits

Peptidyl-prolyl cis/trans isomerases (PPIases) catalyze the cis/trans isomerization of peptidyl-prolyl peptide bonds. Additionally we are shipping Peptidylprolyl Cis/trans Isomerase, NIMA-Interacting 1 Antibodies (212) and Peptidylprolyl Cis/trans Isomerase, NIMA-Interacting 1 Proteins (20) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
PIN1 241593  
PIN1 5300 Q13526
Anti-Rat PIN1 PIN1 298696  
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Top Peptidylprolyl Cis/trans Isomerase, NIMA-Interacting 1 ELISA Kits at antibodies-online.com

Showing 3 out of 7 products:

Catalog No. Reactivity Sensitivity Range Images Quantity Supplier Delivery Price Details
Human 0.39 pg/mL 1.56-100 pg/mL Typical standard curve 96 Tests Log in to see 13 to 16 Days
$910.56
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Cow
  96 Tests Log in to see 15 to 18 Days
$1,029.60
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Mouse
  96 Tests Log in to see 15 to 18 Days
$1,029.60
Details

More ELISA Kits for Peptidylprolyl Cis/trans Isomerase, NIMA-Interacting 1 Interaction Partners

Mouse (Murine) Peptidylprolyl Cis/trans Isomerase, NIMA-Interacting 1 (PIN1) interaction partners

  1. in vivo functional analyses of Pin1 in the GFAP (show GFAP ELISA Kits)-tTA;TRE (show TREH ELISA Kits)-SmoA1 mouse model of Hedgehog (show SHH ELISA Kits)-driven medulloblastoma demonstrate that the loss of Pin1 impairs tumor development and dramatically increases survival.

  2. Data, including data from studies conducted with knockout mice, suggest that Pin1 (prolyl isomerase 1) expression in pancreatic beta-cells is markedly elevated in obesity from diet high in fat/sucrose; Pin1 appears to be involved in proliferation of beta-cells and in regulation of secretion of insulin (show INS ELISA Kits); Pin1 interacts with Sik2 (salt-inducible kinase 2 (show SIK2 ELISA Kits)) to regulate calcium signaling.

  3. Pin1 knockout in lupus-prone MRL lpr mi (show TLR7 ELISA Kits)ce pre (show TLR9 ELISA Kits)vents expres (show IRAK1 ELISA Kits)sion o (show IRF7 ELISA Kits)f lupus phenotype.

  4. By interacting with PSD-95 (show DLG4 ELISA Kits), Pin1 dampens PSD-95 (show DLG4 ELISA Kits) ability to complex with NMDARs, thus negatively affecting NMDAR (show GRIN1 ELISA Kits) signaling and spine morphology.

  5. Oral administration of brown algae polyphenol, a Pin1 inhibitor, reduced fat buildup in mice.

  6. The findings provide evidence for a putative novel role of PIN1 in the development of the nociceptive system and indicate phosphorylation-mediated conformational changes as a mechanism for regulating the PRRXL1 role in the process.

  7. Data show that peptidyl-prolyl isomerase (show PPI ELISA Kits) (Pin1) inhibition inhibits high glucose (HG)-induced cardiac fibroblasts (CFs) proliferation and migration.

  8. Pin1 knock-out mice exhibited disturbed neuronal projections from the cerebral cortex and reduced white matter tracks.

  9. Pin1 plays a vital role on the development of vascular inflammation and atherosclerosis in ApoE (show APOE ELISA Kits)-/- mice.

  10. Studies indicate that Prolyl Isomerase Pin1 (Pin1) Is highly involved in the development of metabolic syndrome.

Xenopus laevis Peptidylprolyl Cis/trans Isomerase, NIMA-Interacting 1 (PIN1) interaction partners

  1. Pin1 is an essential factor regulating CPEB degradation

  2. Pin1 binding is required for the inactivation of XeWee1B at M phase, presumably causing isomerization of the phospho-TP motif and thereby impairing the function of the Wee (show WEE1 ELISA Kits)-box

Human Peptidylprolyl Cis/trans Isomerase, NIMA-Interacting 1 (PIN1) interaction partners

  1. The study demonstrates the oncogenic role of PIN1 in NPC (show NPC1 ELISA Kits) tumorigenesis, and shows that its overexpression can enhance tumor cell growth via the upregulation of cyclinD1.

  2. Pin1 expression was decreased remarkably in temporal lobe epilepsy patients compared to controls.

  3. Data, including data from studies conducted with knockout mice, suggest that PIN1 (prolyl isomerase 1) expression in pancreatic beta-cells is markedly elevated in obesity from diet high in fat/sucrose; PIN1 appears to be involved in proliferation of beta-cells and in regulation of secretion of insulin (show INS ELISA Kits); PIN1 interacts with Sik2 (salt-inducible kinase 2 (show SIK2 ELISA Kits)) to regulate calcium signaling.

  4. Knockdown of PIN1 potently blocks TLR-7 (show TLR7 ELISA Kits)/TLR-9 (show TLR9 ELISA Kits)/Pin1/IRAK-1 (show IRAK1 ELISA Kits)/IRF-7 (show IRF7 ELISA Kits) signaling in vitro.

  5. Data indicate the complexity of interactions between Pin1 and activated IRAK1 (show IRAK1 ELISA Kits), suggesting that phosphorylation of neighboring Ser (show SIGLEC1 ELISA Kits)/Thr (show TRH ELISA Kits)-Pro motifs in proteins might provide competitive advantage at cellular concentrations for engaging with Pin1.

  6. Surprisingly, the authors discover that Pin1 does not promote phosphorylated tau-induced microtubule formation in vitro, refuting the commonly accepted model in which Pin1 binding and catalysis on the A180 epitope restores the function of the Alzheimer's associated phosphorylated tau in tubulin (show TUBB ELISA Kits) assembly.

  7. Importantly, site-specific measurements of Pin1-catalysis of CDK2 (show CDK2 ELISA Kits)/CycA (show CCNA2 ELISA Kits)-phosphorylated full-length tau reveal a number of sites that are catalyzed simultaneously with different efficiencies.

  8. Results show that Pin1 plays a dual role, both positive and negative, in regulating NO production and in mediating the pathogenesis of cardiovascular diseases. Pin1 functions may vary a lot under different circumstances.

  9. reciprocal regulation of Pin1 and XBP1s is associated with the activation of oncogenic pathways, and the relationship of PIN1 and XBP1 (show XBP1 ELISA Kits) may be an attractive target for novel therapy in cancers

  10. When combined with the BRAF (show BRAF ELISA Kits)(V600E)-inhibitor PLX4032 a robust repression in melanoid viability was obtained, establishing preclinical value of patient-derived melanoids for prognostic use of drug sensitivity and further underscoring the beneficial effect of Pin1-FOXM1 (show FOXM1 ELISA Kits) inhibitory peptides as anti-melanoma drugs.

Cow (Bovine) Peptidylprolyl Cis/trans Isomerase, NIMA-Interacting 1 (PIN1) interaction partners

  1. The data provide the first evidence that Pin 1 expression in the granulosa cells but not the theca cells changes during follicular development, and that FSH (show BRD2 ELISA Kits) stimulate the expression of the Pin 1 gene.

Peptidylprolyl Cis/trans Isomerase, NIMA-Interacting 1 (PIN1) Antigen Profile

Antigen Summary

Peptidyl-prolyl cis/trans isomerases (PPIases) catalyze the cis/trans isomerization of peptidyl-prolyl peptide bonds. This gene encodes one of the PPIases, which specifically binds to phosphorylated ser/thr-pro motifs to catalytically regulate the post-phosphorylation conformation of its substrates. The conformational regulation catalyzed by this PPIase has a profound impact on key proteins involved in the regulation of cell growth, genotoxic and other stress responses, the immune response, induction and maintenance of pluripotency, germ cell development, neuronal differentiation, and survival. This enzyme also plays a key role in the pathogenesis of Alzheimer's disease and many cancers. Multiple alternatively spliced transcript variants have been found for this gene.

Gene names and symbols associated with PIN1

  • protein (peptidyl-prolyl cis/trans isomerase) NIMA-interacting 1, retrogene 1 (Pin1rt1) antibody
  • peptidylprolyl cis/trans isomerase, NIMA-interacting 1 (pin1-b) antibody
  • peptidylprolyl cis/trans isomerase, NIMA-interacting 1 (pin1) antibody
  • peptidylprolyl cis/trans isomerase, NIMA-interacting 1 (pin1-a) antibody
  • peptidylprolyl cis/trans isomerase, NIMA-interacting 1 (PIN1) antibody
  • peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (ppiD) antibody
  • peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PITG_11123) antibody
  • peptidylprolyl cis/trans isomerase, NIMA-interacting 1 (Pin1) antibody
  • protein (peptidyl-prolyl cis/trans isomerase) NIMA-interacting 1 (Pin1) antibody
  • 0610025L01Rik antibody
  • D9Bwg1161e antibody
  • DOD antibody
  • OTTMUSG00000014964 antibody
  • pin1 antibody
  • Pin1-ps1 antibody
  • pin1a antibody
  • pin1b antibody
  • Pin1l antibody
  • UBL5 antibody

Protein level used designations for PIN1

peptidylprolyl cis/trans isomerase, NIMA-interacting 1 , peptidylprolyl cis/trans isomerase, NIMA-interacting 1, pseudogene 1 , prolyl isomerase Pin1 b , prolyl isomerase Pin1 , peptidylprolyl cis/trans isomerase, NIMA-interacting 1 b , protein (peptidylprolyl cis/trans isomerase) NIMA-interacting 1 , peptidylprolyl cis/trans isomerase, NIMA-interacting 1 a , peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 , PPIase Pin1 , protein (peptidyl-prolyl cis/trans isomerase) NIMA-interacting 1 , rotamase Pin1 , peptidyl-prolyl cis-trans isomerase Pin1

GENE ID SPECIES
241593 Mus musculus
399385 Xenopus laevis
493472 Xenopus (Silurana) tropicalis
503670 Xenopus laevis
711095 Macaca mulatta
745021 Pan troglodytes
5807350 Sorangium cellulosum So ce56
9476290 Phytophthora infestans T30-4
5300 Homo sapiens
484963 Canis lupus familiaris
298696 Rattus norvegicus
535470 Bos taurus
100512827 Sus scrofa
23988 Mus musculus
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