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PER1 is a member of the Period family of genes and is expressed in a circadian pattern in the suprachiasmatic nucleus, the primary circadian pacemaker in the mammalian brain. Additionally we are shipping PER1 Kits (4) and and many more products for this protein.
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Human Polyclonal PER1 Primary Antibody for EIA, WB - ABIN954090
Xia, Niu, Ma, Cao, Hao, Liu, Wang: Deregulated expression of the Per1 and Per2 in human gliomas. in The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques 2010
Show all 2 references for ABIN954090
Human Polyclonal PER1 Primary Antibody for WB - ABIN1536671
Hwang-Verslues, Chang, Jeng, Kuo, Chiang, Chang, Hsieh, Su, Lin, Abbondante, Yang, Hsu, Yu, Chang, Shew, Lee, Lee: Loss of corepressor PER2 under hypoxia up-regulates OCT1-mediated EMT gene expression and enhances tumor malignancy. in Proceedings of the National Academy of Sciences of the United States of America 2013
Rate-limiting mitochondrial enzymes that process lipids and carbohydrates accumulate in a diurnal manner and are dependent on the clock proteins PER1/2. Diurnal regulation of mitochondrial respiration was blunted in PER1/2 knockout mice.
that the presence of a depressive state around the early active phase of activity may be related to impairment of rhythmicity and expression levels of Per1 and Per2 (show PER2 Antibodies) genes under abnormal light-dark conditions
measured gene expression of Fos, Per1 and Sgk1 (show SGK1 Antibodies) 45 min after exposure to brief cold swim stress in male and female mice; stress induced a stronger increase in Fos and Per1 expression in females than males
Histone monoubiquitination by Clock-Bmal1 (show ARNTL Antibodies) complex marks Per1 and Per2 (show PER2 Antibodies) genes for circadian feedback.
In mice, food intake stimulates oxyntomodulin secretion from the gut (show GUSB Antibodies), which resets liver transcription rhythms via induction of the core clock genes Per1 and 2.
mRNA expression profiles of core clock genes in the liver of Cipc (-/-) mice showed no significant differences from that in wild-type mice except for Per1
Per1 appears to regulate expression of the endothelin axis genes in a tissue-specific and time-dependent manner.
A novel function of USP2 (show USP2 Antibodies) in the molecular clock in which it regulates PER1 function.
Report possible compression of daily activity times in Per1 mutant mice.
Results provide a molecular blueprint for a novel role of PER1 in temporally shaping the daytime-dependency of memory performance, likely, by gating CREB (show CREB1 Antibodies) signaling, and by coupling to downstream chromatin remodeling
ARNTL (show ARNTL Antibodies) and PER1 were associated with PD.
Collectively, these data show that KPNB1 (show KPNB1 Antibodies) is required for timely nuclear import of PER/CRY (show CRY2 Antibodies) in the negative feedback regulation of the circadian clock.
when overexpressed, c-MYC (show MYC Antibodies) is able to repress Per1 transactivation by BMAL1 (show ARNTL Antibodies)/CLOCK via targeting selective E-box sequences. Importantly, upon serum stimulation, MYC (show MYC Antibodies) was detected in BMAL1 (show ARNTL Antibodies) protein complexes
Period 1 and estrogen receptor-beta (show ESR2 Antibodies) are downregulated in Chinese colon cancers.
Data demonstrate a role for Per1 in the transcriptional regulation of NHE3 (show SLC9A3 Antibodies) and SGLT1 (show SLC5A1 Antibodies) in the kidney.
In adipose tissue, acute sleep deprivation vs sleep increased methylation in two promoter-interacting enhancer regions of PER1
In patients with non-small cell lung cancer, loss of Per1 was correlated with poor differentiation, tumor status, high p-TNM stage and lymph node metastasis. Patients with lower expression of Per1, Per2 and Per3 had a shorter survival time.
S714G mutation in hPER1 is associated with feeding rhythms and obesity in mice.
The PER1 c.2247C> T and c.2884C> G polymorphisms singly and in combination were found to be related to the lumbar spine bone mineral density in postmenopausal Korean women.
Functional SNPs found in PER1 were significantly associated with recurrence-free survival in a Chinese population with hepatocellular carcinoma.
This gene is a member of the Period family of genes and is expressed in a circadian pattern in the suprachiasmatic nucleus, the primary circadian pacemaker in the mammalian brain. Genes in this family encode components of the circadian rhythms of locomotor activity, metabolism, and behavior. Circadian expression in the suprachiasmatic nucleus continues in constant darkness, and a shift in the light/dark cycle evokes a proportional shift of gene expression in the suprachiasmatic nucleus. The specific function of this gene is not yet known. Alternative splicing has been observed in this gene\; however, these variants have not been fully described.
, period homolog 1
, circadian clock protein PERIOD 1
, circadian pacemaker protein Rigui
, period circadian protein homolog 1
, Period, drosophila, homolog of
, circadian pacemaker protein RIGUI