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PER3 is a member of the Period family of genes and is expressed in a circadian pattern in the suprachiasmatic nucleus, the primary circadian pacemaker in the mammalian brain. Additionally we are shipping PER3 Antibodies (37) and PER3 Kits (3) and many more products for this protein.
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PER3 variants may be associated with decreased risk for depressive symptoms, including subthreshold levels of depressive symptoms, in older adults.
The PER1 c.2884C > G polymorphism and PER3 54bp VNTR were associated with annual percent changes in bone mineral density of femoral neck after 1 year of hormone therapy.
PER3 polymorphism is associated with sleep quality after a mild traumatic brain injury.
PER3 VNTR polymorphism influences both response to antidepressant chronotherapeutics and total sleep time after the repeated sleep deprivation treatment in patients with bipolar depression.
No association between cluster headache, PER3 VNTR polymorphism and chronotype was found in this study.
There was no significant association between the PER3 VNTR polymorphism and the irregularity of the menstrual cycle in Korean adolescents.
A role for PER3 in modulating circadian clock and mood during seasonal changes
This work suggests a role of PER3 rs10462020 in predicting a prognosis in Diffuse large B-cell lymphoma overall survival of patients.
evidence of an association between PER3 gene and planning performance in a sample of healthy subjects
PER3 VNTR genotype does not explain the difference in chronotype between South African and Dutch marathon runners
Per3 is involved in the suppression of behavioural activity in direct response to light.
evidence for an association of PER3 polymorphisms with juvenile myoclonic epilepsy.
Our data provide strong evidence that variation in the Per3 transcript is causally associated with and also responsive to stress and alcohol.
We found that both the methamphetamine sensitive oscillator and food entrained oscillator in Per1(-/-)/Per2(-/-)/Per3(-/-) mice are circadian oscillators with unusually short ( approximately 21 h) periods.
Per3 exists as homodimers, which are mediated by interactions of the PAS-B beta-sheet surface including a highly conserved tryptophan Trp 359. PER3 homodimers are additionally stabilized by an N-terminal region including a predicted helix-loop-helix motif.
Per3 is a key player in the mammalian circadian system.
Per3(-/-) mice spent less time in wakefulness and more time in NREM sleep in the light period immediately after sleep deprivation and REM sleep accumulated more slowly during the recovery showing a role for PER3 in sleep-wake timing and sleep homeostasis.
Data show that S100a9 (show S100A9 Proteins), Mmp10 (show MMP10 Proteins) and Ang2 (show ANGPT2 Proteins) were among the most downregulated genes, whereas Per3, Tef (show TEF Proteins) and Prdx6 (show PRDX6 Proteins) were significantly upregulated in the DMH (show DST Proteins) + Calcium group.
Per3 as potent mediator of cell fate that functions by altering the transcriptional activity of PPARgamma (show PPARG Proteins).
Mice deficient in Per3 showed increased susceptibility to breast cancer induced by carcinogen treatment or by overexpression of Erbb2 (show ERBB2 Proteins).
This gene is a member of the Period family of genes and is expressed in a circadian pattern in the suprachiasmatic nucleus, the primary circadian pacemaker in the mammalian brain. Genes in this family encode components of the circadian rhythms of locomotor activity, metabolism, and behavior. Circadian expression in the suprachiasmatic nucleus continues in constant darkness, and a shift in the light/dark cycle evokes a proportional shift of gene expression in the suprachiasmatic nucleus. The specific function of this gene is not yet known.
circadian clock protein PERIOD 3
, period circadian protein homolog 3
, period homolog 3
, cell growth-inhibiting gene 13 protein
, growth-inhibiting protein 13
, period 3
, period circadian protein 3