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Peripheral-Type Benzodiazepine Receptor Proteins (TSPO)

Present mainly in the mitochondrial compartment of peripheral tissues, the protein encoded by TSPO interacts with some benzodiazepines and has different affinities than its endogenous counterpart. Additionally we are shipping Peripheral-Type Benzodiazepine Receptor Antibodies (60) and Peripheral-Type Benzodiazepine Receptor Kits (23) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
TSPO 12257 P50637
Rat TSPO TSPO 24230 P16257
TSPO 706 P30536
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Top Peripheral-Type Benzodiazepine Receptor Proteins at antibodies-online.com

Showing 6 out of 6 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 49 to 54 Days
$4,244.78
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 49 to 54 Days
$6,041.49
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
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HOST_Escherichia coli (E. coli) Human Un-conjugated   5 applications Log in to see 1 to 2 Days
$312.71
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HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

TSPO Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human , , ,
, ,

More Proteins for Peripheral-Type Benzodiazepine Receptor (TSPO) Interaction Partners

Mouse (Murine) Peripheral-Type Benzodiazepine Receptor (TSPO) interaction partners

  1. Study reviews the physiological functions of TSPO gene in the mitochondrial permeability transition pore, steroidogenesis and energy metabolism especially in knockout mice. [review]

  2. Study highlights the 3D structure of mTSPO/PBR and in complex with PK11195 providing an important step towards a more detailed understanding of the molecular mechanism of mammalian TSPO/PBR and its interaction with small molecules. [review]

  3. TSPO expression in Sandhoff disease mice is brain region-specific and depends on the age of the animal as disease progresses with the thalamus providing the earliest signal of disease based on TSPO expression and other markers of neurodegeneration

  4. TSPO deficiency does not adversely affect erythropoiesis, heme biosynthesis, bioconversion of ALA to PPIX, and porphyrin-mediated phototoxic cell death.

  5. TSPO can affect mitochondrial energy homeostasis through modulation of fatty acid oxidation, a function that appears to be consistent with high levels of TSPO expression observed in cell types active in lipid storage/metabolism.

  6. Determined is the three-dimensional structure and side-chain dynamics of the A147T polymorph of mouse TSPO in complex with the first-generation ligand PK11195.

  7. Report novel imidazo[1,2-a]pyridine-based TSPO ligands endowed with potential in modulating the steroidogenesis process in murine Leydig tumor cells.

  8. TSPO as a novel element in the regulation of mitochondrial quality control by autophagy, and demonstrate the importance for cell homeostasis of its expression ratio with voltage-dependent anion channel 1 (show VDAC1 Proteins)

  9. Data suggest that Tspo expression is tightly associated with metabolic state of adipocytes and differentiation of preadipocytes into white/brown adipocytes; Tspo expression may improve metabolic status of adipocytes and regulate glucose homeostasis.

  10. TSPO was found necessary for preimplantation embryo development and ACTH (show POMC Proteins)-stimulated steroid biosynthesis

Human Peripheral-Type Benzodiazepine Receptor (TSPO) interaction partners

  1. Study demonstrates that TSPO has an anti-inflammatory role in endothelial activation through the inhibition of VCAM1 (show VCAM1 Proteins) and regulation of mitochondrial function in endothelial cells.

  2. Study focuses on the current understanding of TSPO interplay with reactive oxygen species and the voltage-dependent anion channel to which it binds, in the regulation of cell mitophagy. [review]

  3. The authors discuss findings about TSPO and its function in the steroidogenesis which are inconclusive at this time. [Review]

  4. Studies confirmed that TSPO expression increases with tumor grade in astrocytomas but also that some overlap exists between Low-grade and anaplastic lesions.

  5. This work implicates TSPO in the maintenance of mitochondrial membrane integrity and in the control of mitochondrial ROS (show ROS1 Proteins) production, ultimately favoring tissue regeneration.

  6. We conclude that ScBsAbAgn-2/TSPO targeting of glioblastoma cell lines can be achieved in vitro and in vivo.

  7. Exposure of cells to CS resulted in alternation of biomolecules expressed by CLs peroxidation, reduction of TSPO binding, and depletion of the mitochondrial potential. This irreversible damage was enhanced in the presence of saliva (show RAG1AP1 Proteins)

  8. Study show that TSPO is highly expressed in human glioma and correlates with grade and represents a promising target in human glioma imaging for detection and staging.

  9. Elevations in microglial activity can be measured in vivo with positron emission tomography (PET) using radioligands specific for the 18kD translocator-protein (TSPO), which is expressed on microglia.

  10. Our preliminary results suggest that TSPO brain imaging in GBM may be a useful tool for predicting tumor progression at follow-up and may be less susceptible to changes in blood-brain barrier permeability than (18)F-FET.

Pig (Porcine) Peripheral-Type Benzodiazepine Receptor (TSPO) interaction partners

  1. PBR mRNA was the more abundant detected form in pig tissues and in warm kidney that underwent ischemia suggesting functional implications of PBR during the renal repair process.

  2. Changes in TSPO expression in kidney regenerating tissue could be important for renal protection and maintenance of kidney function.

Peripheral-Type Benzodiazepine Receptor (TSPO) Protein Profile

Protein Summary

Present mainly in the mitochondrial compartment of peripheral tissues, the protein encoded by this gene interacts with some benzodiazepines and has different affinities than its endogenous counterpart. The protein is a key factor in the flow of cholesterol into mitochondria to permit the initiation of steroid hormone synthesis. Alternatively spliced transcript variants have been reported\; one of the variants lacks an internal exon and is considered non-coding, and the other variants encode the same protein.

Gene names and symbols associated with TSPO

  • peripheral-type benzodiazepine receptor (LOC732875)
  • peripheral-type benzodiazepine receptor (MAV_3896)
  • Peripheral-type benzodiazepine receptor (xccb100_2086)
  • peripheral-type benzodiazepine receptor (Smp_102510)
  • peripheral-type benzodiazepine receptor (Sros_1911)
  • peripheral-type benzodiazepine receptor (LOC100136652)
  • peripheral-type benzodiazepine receptor (LOC100280949)
  • peripheral-type benzodiazepine receptor (PGTG_16395)
  • peripheral-type benzodiazepine receptor (PBR)
  • translocator protein (Tspo)
  • translocator protein (18kDa) (TSPO)
  • translocator protein (18kDa) (Tspo)
  • translocator protein-like (LOC100338710)
  • BPBS protein
  • Bzrp protein
  • DBI protein
  • IBP protein
  • LOC732875 protein
  • LOC100136652 protein
  • LOC100280949 protein
  • MBR protein
  • mDRC protein
  • PBR protein
  • PBS protein
  • pk18 protein
  • PKBS protein
  • PTBR protein
  • Ptbzr protein
  • PTBZR02 protein
  • RATPTBZR02 protein
  • TSPO protein
  • Tspo1 protein

Protein level used designations for TSPO

peripheral-type benzodiazepine receptor , Peripheral-type benzodiazepine receptor , translocator protein , PKBS , benzodiazepine receptor, peripheral , isoquinoline-binding protein , mitochondrial benzodiazepine receptor , Benzodiazepin receptor (peripheral) , PBR , benzodiazepine peripheral binding site , peripheral benzodiazepine receptor , IBP , benzodiazepine receptor (peripheral)

GENE ID SPECIES
732875 Bombyx mori
4529395 Mycobacterium avium 104
6322197 Xanthomonas campestris pv. campestris str. B100
8346408 Schistosoma mansoni
8665189 Streptosporangium roseum DSM 43021
100136652 Oncorhynchus mykiss
100280949 Zea mays
10528866 Puccinia graminis f. sp. tritici CRL 75-36-700-3
443123 Ovis aries
12257 Mus musculus
24230 Rattus norvegicus
706 Homo sapiens
396592 Sus scrofa
281033 Bos taurus
474475 Canis lupus familiaris
418226 Gallus gallus
100722263 Cavia porcellus
100338710 Oryctolagus cuniculus
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