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The protein encoded by PPHLN1 is one of the several proteins that become sequentially incorporated into the cornified cell envelope during the terminal differentiation of keratinocyte at the outer layers of epidermis. Additionally we are shipping PPHLN1 Proteins (7) and many more products for this protein.
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Human Polyclonal PPHLN1 Primary Antibody for WB - ABIN1881676
Imami, Sugiyama, Kyono, Tomita, Ishihama: Automated phosphoproteome analysis for cultured cancer cells by two-dimensional nanoLC-MS using a calcined titania/C18 biphasic column. in Analytical sciences : the international journal of the Japan Society for Analytical Chemistry 2008
Show all 5 references for ABIN1881676
Human Polyclonal PPHLN1 Primary Antibody for EIA, IF - ABIN1450117
Kazerounian, Aho: Characterization of periphilin, a widespread, highly insoluble nuclear protein and potential constituent of the keratinocyte cornified envelope. in The Journal of biological chemistry 2003
Human Polyclonal PPHLN1 Primary Antibody for ICC, IF - ABIN4347031
Tchasovnikarova, Timms, Matheson, Wals, Antrobus, Göttgens, Dougan, Dawson, Lehner: GENE SILENCING. Epigenetic silencing by the HUSH complex mediates position-effect variegation in human cells. in Science (New York, N.Y.) 2015
The haploid screen identified HUSH, an epigenetic heterochromatin repressor complex composed of three subunits, TASOR, MPP8 (show MPHOSPH8 Antibodies) and Periphilin. (Review)
analysis of FGFR2 (show FGFR2 Antibodies)-PPHLN1 fusion and ARAF (show ARAF Antibodies) mutations in intrahepatic cholangiocarcinoma
this study identified the HUSH (human silencing hub) complex, comprising three poorly characterized proteins, TASOR, MPP8 (show MPHOSPH8 Antibodies), and periphilin; this complex is absent from Drosophila but is conserved from fish to humans.
Data show that periphilin displays an overlapping expression pattern with synphilin-1 (show SNCAIP Antibodies) in cellular and animal models and in Lewy bodies of Parkinson's disease (PD) patients, and support involvement of periphilin in PD.
periphilin is potentially involved in epithelial differentiation and contributes to epidermal integrity and barrier formation
CR (periphilin) retards S-phase progression by modifying expression of Cdc7 (show CDC7 Antibodies) and other genes involved in progression of DNA replication
results point to an indispensable function of periphilin during murine development and an important role in the nervous system, reflected by a strong and tightly regulated expression in the murine brain.
The protein encoded by this gene is one of the several proteins that become sequentially incorporated into the cornified cell envelope during the terminal differentiation of keratinocyte at the outer layers of epidermis. This protein interacts with periplakin, which is known as a precursor of the cornified cell envelope. The cellular localization pattern and insolubility of this protein suggest that it may play a role in epithelial differentiation and contribute to epidermal integrity and barrier formation. Multiple alternatively spliced transcript variants encoding distinct isoforms have been observed.
, gastric cancer antigen Ga50