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The protein encoded by PPHLN1 is one of the several proteins that become sequentially incorporated into the cornified cell envelope during the terminal differentiation of keratinocyte at the outer layers of epidermis. Additionally we are shipping PPHLN1 Antibodies (51) and PPHLN1 Proteins (7) and many more products for this protein.
The haploid screen identified HUSH, an epigenetic heterochromatin repressor complex composed of three subunits, TASOR, MPP8 and Periphilin. (Review)
analysis of FGFR2 (show FGFR2 ELISA Kits)-PPHLN1 fusion and ARAF (show ARAF ELISA Kits) mutations in intrahepatic cholangiocarcinoma
this study identified the HUSH (human silencing hub) complex, comprising three poorly characterized proteins, TASOR, MPP8, and periphilin; this complex is absent from Drosophila but is conserved from fish to humans.
Data show that periphilin displays an overlapping expression pattern with synphilin-1 (show SNCAIP ELISA Kits) in cellular and animal models and in Lewy bodies of Parkinson's disease (PD) patients, and support involvement of periphilin in PD.
periphilin is potentially involved in epithelial differentiation and contributes to epidermal integrity and barrier formation
CR (periphilin) retards S-phase progression by modifying expression of Cdc7 (show CDC7 ELISA Kits) and other genes involved in progression of DNA replication
results point to an indispensable function of periphilin during murine development and an important role in the nervous system, reflected by a strong and tightly regulated expression in the murine brain.
The protein encoded by this gene is one of the several proteins that become sequentially incorporated into the cornified cell envelope during the terminal differentiation of keratinocyte at the outer layers of epidermis. This protein interacts with periplakin, which is known as a precursor of the cornified cell envelope. The cellular localization pattern and insolubility of this protein suggest that it may play a role in epithelial differentiation and contribute to epidermal integrity and barrier formation. Multiple alternatively spliced transcript variants encoding distinct isoforms have been observed.
, gastric cancer antigen Ga50