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Periplakin Proteins (PPL)

The protein encoded by PPL is a component of desmosomes and of the epidermal cornified envelope in keratinocytes. Additionally we are shipping Periplakin Antibodies (47) and Periplakin Kits (7) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
PPL 5493 O60437
Rat PPL PPL 302934  
PPL 19041 Q9R269
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Top Periplakin Proteins at antibodies-online.com

Showing 3 out of 5 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag,GST tag 100 μg Log in to see 11 to 13 Days
$841.50
Details
HOST_Escherichia coli (E. coli) Mouse His tag,T7 tag 100 μg Log in to see 11 to 13 Days
$771.10
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 9 to 19 Days
$1,014.95
Details

PPL Proteins by Origin and Source

Origin Expressed in Conjugate
Human
,
Mouse (Murine)

More Proteins for Periplakin (PPL) Interaction Partners

Human Periplakin (PPL) interaction partners

  1. Low serum periplakin is associated with urothelial carcinoma.

  2. Human gamma-delta T cells are activated by cytosolic interactions of BTN3A1 (show BTN3A1 Proteins) with soluble phosphoantigens and the cytoskeletal adaptor periplakin.

  3. Loss of periplakin expression is associated with pathological stage and cancer-specific survival in patients with urothelial carcinoma of the urinary bladder.

  4. Annexin A9 (show ANXA9 Proteins) and periplakin co-localise in the epidermis and annexin A9 (show ANXA9 Proteins) is up-regulated in differentiating keratinocytes, but the epidermal annexin A9 (show ANXA9 Proteins) expression does not require periplakin.

  5. Sciellin (show SCEL Proteins), SPRR3 (show SPRR3 Proteins), and periplakin transcripts were all upregulated (4.67-, 4.95-, 2.77-fold, respectively) by prolonged exposure to cyclic strain (24-72 h), but not at earlier time points.

  6. autoantibodies are detected in patients with paraneoplastic pemphigus

  7. This protein binds to protein kinase B (show AKT1 Proteins).

  8. in spite of its high homology and structural similarity with envoplakin, periplakin is functionally closer to the plakin proteins plectin and desmoplakin, and may function tissue-wide as a scaffolding protein in intermediate filament assembly

  9. interactions between helix VIII of the human mu-opioid receptors and the C terminus of periplakin disrupt G protein activation

  10. envoplakin and periplakin bind to the plasma membrane upon elevation of intracellular [Ca(2 (show CA2 Proteins)+)] in differentiating keratinocytes, where they serve as a scaffold for cornified cell envelope assembly

Mouse (Murine) Periplakin (PPL) interaction partners

  1. Data suggest that the primary role of periplakin may not relate to the physiology of the cornified cell envelope in epidermal keratinocytes but may reside in the challenges, which normal laboratory mice do not encounter.

  2. Periplakin interferes with G protein activation by the melanin-concentrating hormone receptor-1 (show MCHR1 Proteins) by binding to the proximal segment of the receptor C-terminal tail

Periplakin (PPL) Protein Profile

Protein Summary

The protein encoded by this gene is a component of desmosomes and of the epidermal cornified envelope in keratinocytes. The N-terminal domain of this protein interacts with the plasma membrane and its C-terminus interacts with intermediate filaments. Through its rod domain, this protein forms complexes with envoplakin. This protein may serve as a link between the cornified envelope and desmosomes as well as intermediate filaments. AKT1/PKB, a protein kinase mediating a variety of cell growth and survival signaling processes, is reported to interact with this protein, suggesting a possible role for this protein as a localization signal in AKT1-mediated signaling.

Gene names and symbols associated with Periplakin Proteins (PPL)

  • periplakin (PPL)
  • periplakin (ppl)
  • periplakin (LOC100343940)
  • periplakin (Ppl)
  • AW553870 protein
  • cb180 protein
  • im:7140067 protein
  • im:7149519 protein
  • sb:cb180 protein

Protein level used designations for Periplakin Proteins (PPL)

periplakin , periplakin-like , 190 kDa paraneoplastic pemphigus antigen , 195 kDa cornified envelope precursor protein , 195kDa protein

GENE ID SPECIES
408044 Gallus gallus
449936 Danio rerio
453893 Pan troglodytes
490021 Canis lupus familiaris
495053 Xenopus laevis
710266 Macaca mulatta
100069951 Equus caballus
100343940 Oryctolagus cuniculus
100407595 Callithrix jacchus
100460826 Pongo abelii
100512773 Sus scrofa
100547953 Meleagris gallopavo
100563033 Anolis carolinensis
100602203 Nomascus leucogenys
5493 Homo sapiens
522886 Bos taurus
302934 Rattus norvegicus
19041 Mus musculus
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