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The product of PEX3 is involved in peroxisome biosynthesis and integrity. Additionally we are shipping PEX3 Proteins (8) and many more products for this protein.
Showing 10 out of 22 products:
Chicken Polyclonal PEX3 Primary Antibody for IHC, WB - ABIN2782478
Fang, Morrell, Jones, Gould: PEX3 functions as a PEX19 docking factor in the import of class I peroxisomal membrane proteins. in The Journal of cell biology 2004
This insertion of PEX3 into the ER is physiologically relevant.
PEX16 (show PEX16 Antibodies) mediates the peroxisomal trafficking of two distinct peroxisomal membrane proteins, PEX3 and PMP34 (show SLC25A17 Antibodies), via the endoplasmic reticulum
Thus within the cell, PEX3 is stabilized by PEX19 (show PEX19 Antibodies) preventing PEX3 aggregation.
Mutations in the PEX19 (show PEX19 Antibodies)-binding domain of PEX3 reduce the affinity for PEX19 (show PEX19 Antibodies) and destabilize PEX3.
The crystal structure of the cytosolic domain of PEX3 in complex with a PEX19 (show PEX19 Antibodies)-derived peptide. PEX3 adopts a novel fold that is best described as a large helical bundle.
Interaction of PEX3 and PEX19 (show PEX19 Antibodies) visualized by fluorescence resonance energy transfer (FRET).
Results suggest that PEX3 plays a selective, essential, and direct role in class I peroxisomal membrane protein import as a docking factor for PEX19 (show PEX19 Antibodies).
either one or two tryptophan residues of Pex3p (Trp (show TBPL1 Antibodies)-104 and Trp (show TBPL1 Antibodies)-224) are directly involved in binding to Pex19p.
The cytosolic domain of PEX3, a protein involved in the biogenesis of peroxisomes, binds membrane lipids.
The product of this gene is involved in peroxisome biosynthesis and integrity. It assembles membrane vesicles before the matrix proteins are translocated. Peroxins (PEXs) are proteins that are essential for the assembly of functional peroxisomes. The peroxisome biogenesis disorders (PBDs) are a group of genetically heterogeneous autosomal recessive, lethal diseases characterized by multiple defects in peroxisome function. The peroxisomal biogenesis disorders are a heterogeneous group with at least 14 complementation groups and with more than 1 phenotype being observed in cases falling into particular complementation groups. Although the clinical features of PBD patients vary, cells from all PBD patients exhibit a defect in the import of one or more classes of peroxisomal matrix proteins into the organelle. Defects in this gene are a cause Zellweger syndrome (ZWS).
peroxisomal biogenesis factor 3
, transmembrane protein
, peroxisomal assembly protein PEX3
, transformation-related protein 18
, Peroxisomal assembly protein PEX3
, peroxisomal assembly protein 3
, Peroxisomal biogenesis factor 3