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anti-Peroxisomal Biogenesis Factor 5 (PEX5) Antibodies

The product of PEX5 binds to the C-terminal PTS1-type tripeptide peroxisomal targeting signal (SKL-type) and plays an essential role in peroxisomal protein import. Additionally we are shipping PEX5 Proteins (5) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
PEX5 19305 O09012
PEX5 312703 Q2M2R8
PEX5 5830 P50542
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Top anti-PEX5 Antibodies at antibodies-online.com

Showing 10 out of 31 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-PEX5 Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:62500Positive Control: ACHN cell lysate 100 μL Log in to see 2 to 3 Days
$289.00
Details
Chicken Rabbit Un-conjugated WB WB Suggested Anti-PEX5 Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:312500Positive Control: COLO205 cell lysate 100 μL Log in to see 2 to 3 Days
$289.00
Details
Mouse Mouse Un-conjugated IF, WB Western blot analysis of PEX5 on a RSV-3T3 cell lysate. Lane 1: 1:250, lane 2: 1:500, lane 3: 1:1000 dilution of the mouse anti-mouse PEX5 antibody. Immunofluorescence staining of NIH/3T3 cells (Mouse embryo fibroblast cells, ATCC CRL-1658). 50 μg Log in to see 5 to 6 Days
$205.42
Details
Human Rabbit Un-conjugated IHC (p), WB 100 μL Log in to see 8 to 10 Days
$507.83
Details
Human Mouse Un-conjugated IF, WB Anti-PEX5 mouse monoclonal antibody (ABIN2453448) immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY PEX5 (RC202062). HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY PEX5 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 µg per lane) were separated by SDS-PAGE and immunoblotted with anti-PEX5. 100 μL Log in to see 2 to 3 Days
$423.50
Details
Human Mouse Un-conjugated IF, WB Anti-PEX5 mouse monoclonal antibody (ABIN2453449) immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY PEX5 (RC202062). HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY PEX5 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 µg per lane) were separated by SDS-PAGE and immunoblotted with anti-PEX5. 100 μL Log in to see 2 to 3 Days
$423.50
Details
Human Mouse Un-conjugated FACS, IF, WB Anti-PEX5 mouse monoclonal antibody (ABIN2453451) immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY PEX5 (RC202062). HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY PEX5 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 µg per lane) were separated by SDS-PAGE and immunoblotted with anti-PEX5. 100 μL Log in to see 2 to 3 Days
$482.90
Details
Human Rabbit Un-conjugated WB 50 μg Log in to see 8 to 10 Days
$551.83
Details
Human Rabbit Un-conjugated WB 50 μg Log in to see 8 to 10 Days
$551.83
Details
Human Mouse Un-conjugated FACS, IF, WB 100 μL Log in to see 8 to 10 Days
$529.83
Details

PEX5 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality
Mouse (Murine)
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Rat (Rattus)
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Human ,
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Top referenced anti-PEX5 Antibodies

  1. Mouse (Murine) Monoclonal PEX5 Primary Antibody for IF, WB - ABIN968605 : Baes, Gressens, Baumgart, Carmeliet, Casteels, Fransen, Evrard, Fahimi, Declercq, Collen, van Veldhoven, Mannaerts: A mouse model for Zellweger syndrome. in Nature genetics 1997 (PubMed)
    Show all 4 references for ABIN968605

  2. Chicken Polyclonal PEX5 Primary Antibody for WB - ABIN2786513 : Maynard, Berg: Quantitative analysis of peroxisomal targeting signal type-1 binding to wild-type and pathogenic mutants of Pex5p supports an affinity threshold for peroxisomal protein targeting. in Journal of molecular biology 2007 (PubMed)

More Antibodies against PEX5 Interaction Partners

Mouse (Murine) Peroxisomal Biogenesis Factor 5 (PEX5) interaction partners

  1. monoubiquitination of the N-terminal cysteine of peroxisome-associated PEX5 not only functions to recycle the peroxin back to the cytosol, but also serves as a quality control mechanism to eliminate peroxisomes with a defective protein import machinery

  2. Demyelination in cerebellum and brain stem preceded major myelin loss in corpus callosum of Pex5 deficient mice.

  3. interaction of PEX5 with catalase (show CAT Antibodies) and PEX14 (show PEX14 Antibodies)

  4. Peroxisomes were selectively reconstituted in brain or liver of Pex5 knock-out mice, a model for Zellweger syndrome (show PEX1 Antibodies), by tissue-selective overexpression of Pex5p. We found that both rescue strains exhibited a correction of the neuronal migration defect

Human Peroxisomal Biogenesis Factor 5 (PEX5) interaction partners

  1. our data suggest that insertion of the trimeric PEX5-PEX7 (show PEX7 Antibodies)-PTS2 protein complex into the DTM is probably accompanied by conformational alterations in PEX5 to allow release of the PTS2 protein into the organelle matrix

  2. Our data suggest that the functional polymorphism rs3814058C>T in 3'-UTR (show UTS2R Antibodies) of PXR (show NR1I2 Antibodies) may be a functional biomarker to predict risk of colorectal cancer

  3. PEX5 encodes two isoforms, PEX5L (show PEX5L Antibodies) & PEX5S, & a homozygous frame shift mutation c.722dupA (p.Val242Glyfs( *)33), located in the PEX5L (show PEX5L Antibodies)-specific exon 9, results in loss of PEX5L (show PEX5L Antibodies) only. Loss of PEX5L (show PEX5L Antibodies) results in deficient import of PTS2-tagged proteins

  4. bulky side chain within the recognition motif, which blocks contraction of the PEX5 binding cavity

  5. Data show that ataxia-telangiectasia mutated (ATM (show ATM Antibodies)) phosphorylates peroxisomal biogenesis factor 5 (PEX5) at serine 141 in response to reactive oxygen species.

  6. ubiquitination of peroxisome-targeting signal type 1 (PTS1) receptor Pex5p regulating PTS1 protein import

  7. PEX5 has a role in regulating peroxisome numbers by signaling to mediate pexophagy

  8. Cys11 in PEX5 serves as a functional redox switch regulating the peroxisomal/cytosolic localization of peroxisomal proteins.

  9. The novel Pex14 (show PEX14 Antibodies)-binding site may represent the initial tethering site of Pex5 from which the cargo-loaded receptor is further processed in a sequential manner.

  10. Translocation of proteins across the organelle membrane occurs downstream of a reversible docking step and upstream of the first cytosolic ATP-dependent step, i.e. before ubiquitination of PEX5.

PEX5 Antigen Profile

Protein Summary

The product of this gene binds to the C-terminal PTS1-type tripeptide peroxisomal targeting signal (SKL-type) and plays an essential role in peroxisomal protein import. Peroxins (PEXs) are proteins that are essential for the assembly of functional peroxisomes. The peroxisome biogenesis disorders (PBDs) are a group of genetically heterogeneous autosomal recessive, lethal diseases characterized by multiple defects in peroxisome function. The peroxisomal biogenesis disorders are a heterogeneous group with at least 14 complementation groups and with more than 1 phenotype being observed in cases falling into particular complementation groups. Although the clinical features of PBD patients vary, cells from all PBD patients exhibit a defect in the import of one or more classes of peroxisomal matrix proteins into the organelle. Defects in this gene are a cause of neonatal adrenoleukodystrophy (NALD), a cause of Zellweger syndrome (ZWS) as well as may be a cause of infantile Refsum disease (IRD). Alternatively spliced transcript variants encoding different isoforms have been identified.

Gene names and symbols associated with PEX5

  • peroxisomal biogenesis factor 5 (pex5) antibody
  • peroxisomal biogenesis factor 5 (Pex5) antibody
  • peroxisomal biogenesis factor 5 (PEX5) antibody
  • AW212715 antibody
  • ESTM1 antibody
  • PBD2A antibody
  • PBD2B antibody
  • Peroxin-5 antibody
  • PTS1-BP antibody
  • PTS1R antibody
  • PXR1 antibody
  • X83306 antibody

Protein level used designations for PEX5

peroxisome biogenesis factor 5 , PTS1 receptor , PTS1-BP , PXR1P , peroxin 5 , peroxisomal C-terminal targeting signal import receptor , peroxisomal targeting signal 1 receptor , peroxisome receptor 1 , peroxin-5 , peroxisomal targeting signal 1 (SKL type) receptor , peroxisomal targeting signal import receptor , peroxisomal targeting signal receptor 1 , PTS1R , Peroxisomal C-terminal targeting signal import receptor , Peroxisome receptor 1

GENE ID SPECIES
496849 Xenopus (Silurana) tropicalis
19305 Mus musculus
312703 Rattus norvegicus
5830 Homo sapiens
486710 Canis lupus familiaris
514832 Bos taurus
418299 Gallus gallus
100135597 Cavia porcellus
100689015 Cricetulus griseus
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