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anti-Peroxisome Proliferator-Activated Receptor Gamma, Coactivator 1 alpha (PPARGC1A) Antibodies

The protein encoded by PPARGC1A is a transcriptional coactivator that regulates the genes involved in energy metabolism. Additionally we are shipping PPARGC1A Kits (1) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
Anti-Mouse PPARGC1A PPARGC1A 19017 O70343
Anti-Human PPARGC1A PPARGC1A 10891 Q9UBK2
Anti-Rat PPARGC1A PPARGC1A 83516 Q9QYK2
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More Antibodies against PPARGC1A Interaction Partners

Mouse (Murine) Peroxisome Proliferator-Activated Receptor Gamma, Coactivator 1 alpha (PPARGC1A) interaction partners

  1. Skeletal muscle-PGC (show PGC Antibodies)-1a is important for leucine-mediated mTOR (show FRAP1 Antibodies) activation and protein biosynthesis.

  2. H2S augmented the S-sulfhydration of the rate-limiting gluconeogenic enzymes and PGC-1alpha and increased their activities, which were lower in untreated : To investigate the regulation of hepatic glucose production by cystathionine gamma-lyase (show CTH Antibodies) KO hepatocytes

  3. the present results suggest a role of skeletal muscle PGC-1alpha in coordinating several exercise-induced adaptive responses including autophagic removal of damaged cellular components.

  4. PGC-1alpha gene transfer improves muscle function in dystrophic muscle following prolonged disease progression.

  5. Data suggest beta-adrenergic activation of brown adipocytes leads to dissociation of Hdac1 (show HDAC1 Antibodies) from promoters of Ucp1 (show UCP1 Antibodies)/Pgc1a, to up-regulation of histone H3 (show HIST3H3 Antibodies) acetylation, to dissociation of polycomb (show CBX2 Antibodies) repressive complexes, and to up-regulation of thermogenesis.

  6. PGC1a is necessary for HSF1 (show HSF1 Antibodies)'s metabolic action in inguinal fat tissues.

  7. Electroacupuncture improves brain energy metabolism, potentially associated with the upregulation of SIRT1 (show SIRT1 Antibodies)-dependent PGC-1alpha expression

  8. Evogliptin treatment also differentially increased Ppargc1a expression, a key metabolic regulator, in WAT, but not in skeletal muscle and brown adipose tissue

  9. PGC-1alpha modulates telomere function and length as well as DNA damage. PGC-1alpha disruption promotes vascular aging and atherosclerosis.

  10. Study demonstrate a significant increase of the promoter methylation in Parkinson's disease midbrain tissue that is accompanied by decreased PGC-1alpha gene and protein expression.

Pig (Porcine) Peroxisome Proliferator-Activated Receptor Gamma, Coactivator 1 alpha (PPARGC1A) interaction partners

  1. Polymorphisms in PPARGC1A and CAPNS1 (show CAPNS1 Antibodies) genes may affect meat quality traits.

Human Peroxisome Proliferator-Activated Receptor Gamma, Coactivator 1 alpha (PPARGC1A) interaction partners

  1. were observed to be significantly increased in the PGC-1alpha group compared with the control group. These results indicate that PGC-1alpha is able to induce angiogenesis in hRVECs and retinas, and suggests that PGC-1alpha is a potential anti-angiogenic target in retinal neovascularization.

  2. Novel angiogenic agent COA-Cl induced activation of PGC-1alpha/ERRalpha/VEGF signaling pathway in fibroblasts.

  3. Suggest that neither plasma adrenaline nor muscle metabolic stress determines the magnitude of PGC-1alpha mRNA response in exercising human muscle.

  4. Combined speed endurance and endurance exercise amplify the exercise-induced PGC-1alpha and PDK4 (show PDK4 Antibodies) mRNA response in trained human muscle.

  5. The Gly482Ser polymorphism of the peroxisome proliferator-activated receptor-gamma (show PPARG Antibodies) coactivator-1alpha is associated with type 2 diabetes

  6. Data suggest that PGC1A/PPARGC1A plays roles in regulation of (1) energy metabolism in adipose tissue, (2) gluconeogenesis in liver, (3) insulin (show INS Antibodies) resistance in skeletal muscle, and (4) insulin (show INS Antibodies) secretion in pancreatic beta cells. [REVIEW]

  7. PGC-1alpha mRNA significantly increased by 25.8-fold after alternate-day and 10.1-fold after consecutive-day training, while protein levels increased 1.5-1.7 fold in both protocols.

  8. The PPARGC1A rs8192678 GA/AA genotype and the PNPLA3 (show PNPLA3 Antibodies) rs738409 GG genotype had an additive effect on NASH (show SAMSN1 Antibodies) in severely obese Taiwanese patients.

  9. This study provides important insights into the metabolic changes associated with RPE (show RPE Antibodies) functional maturation and identifies PGC-1alpha as a potent driver of RPE (show RPE Antibodies) mitochondrial function and antioxidant capacity.

  10. Suppression of MYC and subsequent increase of PGC-1alpha were identified as key determinants for the OXPHOS dependency of CSCs, which was abolished in resistant CSC clones.

Cow (Bovine) Peroxisome Proliferator-Activated Receptor Gamma, Coactivator 1 alpha (PPARGC1A) interaction partners

  1. The PPARGC1A synonymous mutation c.396G>A significantly associated with body weight and average daily gain in Nanyang cattle at the adult age.

  2. PPARGC1A genotypes had a significant effect on lengths of calving interval and calving to conception interval, and the T allele was demonstrated to have an unfavourable effect on these traits.

  3. NO/protein kinase (show CDK7 Antibodies) G (PKG (show PRKG1 Antibodies))-dependent downregulation of PGC-1 alpha and the ROS (show ROS1 Antibodies) detoxification system in endothelial cells are mediated by the PI3K/Akt (show AKT1 Antibodies) signaling

  4. The effects of dietary fat components on the expression of PPAR-gamma (show PPARG Antibodies) AND PPAR-gamma coactivator 1 in cultured bovine preadipocytes are reported.

  5. genetic analysis of bovine PPARGC1A

  6. PPARGC1A was associated with a significant increase in milk protein (show CSN2 Antibodies) percentage in contrast to association results previously reported for the German Holstein population

PPARGC1A Antigen Profile

Protein Summary

The protein encoded by this gene is a transcriptional coactivator that regulates the genes involved in energy metabolism. This protein interacts with PPARgamma, which permits the interaction of this protein with multiple transcription factors. This protein can interact with, and regulate the activities of, cAMP response element binding protein (CREB) and nuclear respiratory factors (NRFs). It provides a direct link between external physiological stimuli and the regulation of mitochondrial biogenesis, and is a major factor that regulates muscle fiber type determination. This protein may be also involved in controlling blood pressure, regulating cellular cholesterol homoeostasis, and the development of obesity.

Gene names and symbols associated with PPARGC1A

  • peroxisome proliferator-activated receptor gamma, coactivator 1 alpha (PPARGC1A) antibody
  • peroxisome proliferative activated receptor, gamma, coactivator 1 alpha (Ppargc1a) antibody
  • peroxisome proliferator activated receptor gamma, coactivator 1 alpha (PPARGC-1) antibody
  • peroxisome proliferator-activated receptor gamma, coactivator 1 alpha (Ppargc1a) antibody
  • peroxisome proliferator-activated receptor gamma, coactivator 1 alpha (ppargc1a) antibody
  • A830037N07Rik antibody
  • AVPGC-1ALPHA antibody
  • ENSMUSG00000079510 antibody
  • Gm11133 antibody
  • LEM6 antibody
  • PGC-1 antibody
  • PGC-1(alpha) antibody
  • Pgc-1alpha antibody
  • PGC-1v antibody
  • PGC1 antibody
  • PGC1A antibody
  • Pgco1 antibody
  • Ppargc1 antibody
  • PPARGC1A antibody

Protein level used designations for PPARGC1A

peroxisome proliferator-activated receptor gamma, coactivator 1 alpha , PPAR-gamma coactivator , peroxisome proliferator activated receptor gamma coactivator-1 , PGC-1-alpha , PPAR Gamma Coactivator-1 , PPAR gamma coactivator variant form , PPAR-gamma coactivator 1-alpha , PPARGC-1-alpha , Pgc-1alphaa , peroxisome proliferator-activated receptor gamma coactivator 1-alpha , L-PGC-1alpha , ligand effect modulator-6 , peroxisome proliferator-activated receptor gamma coactivator 1 alpha transcript variant B4 , peroxisome proliferator-activated receptor gamma coactivator 1 alpha transcript variant B4-3ext , peroxisome proliferator-activated receptor gamma coactivator 1 alpha transcript variant B4-8a , peroxisome proliferator-activated receptor gamma coactivator 1 alpha transcript variant B5 , peroxisome proliferator-activated receptor gamma coactivator 1 alpha transcript variant B5-NT , peroxisome proliferative activated receptor, gamma, coactivator 1 , peroxisome proliferator activated receptor gamma coactivator 1 alpha , PGC-1alpha , peroxisome proliferative activated receptor gamma coactivator 1 , peroxisome proliferative activated receptor, gamma, coactivator 1 alpha , proliferator-activated receptor gamma coactivator 1 alpha , peroxisome proliferative activated receptor, gamma, coactivator 1, alpha , peroxisome-proliferator-activated receptor-gamma co-activator-1

GENE ID SPECIES
443270 Ovis aries
19017 Mus musculus
397013 Sus scrofa
10891 Homo sapiens
479127 Canis lupus familiaris
338446 Bos taurus
83516 Rattus norvegicus
100462892 Xenopus laevis
422815 Gallus gallus
100349219 Oryctolagus cuniculus
100721512 Cavia porcellus
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