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anti-Peroxisome Proliferator-Activated Receptor Gamma, Coactivator 1 alpha (PPARGC1A) Antibodies

The protein encoded by PPARGC1A is a transcriptional coactivator that regulates the genes involved in energy metabolism. Additionally we are shipping PPARGC1A Kits (1) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
Anti-Mouse PPARGC1A PPARGC1A 19017 O70343
Anti-Human PPARGC1A PPARGC1A 10891 Q9UBK2
Anti-Rat PPARGC1A PPARGC1A 83516 Q9QYK2
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More Antibodies against PPARGC1A Interaction Partners

Mouse (Murine) Peroxisome Proliferator-Activated Receptor Gamma, Coactivator 1 alpha (PPARGC1A) interaction partners

  1. Overexpressing hsp60 (show HSPD1 Antibodies) in cultured myoblasts induced only the expression of PGC1 1alpha, suggesting a correlation between Hsp60 (show HSPD1 Antibodies) overexpression and PGC1 1 alpha activation.

  2. TWEAK (show TNFSF12 Antibodies)/Fn14 (show TNFRSF12A Antibodies) signaling represses PGC-1alpha expression during acute kidney injury through activation of canonical NF-kappaB (show NFKB1 Antibodies) pathways and epigenetic mechanisms including histone deacetylation on NF-kappaB (show NFKB1 Antibodies)-binding sites.

  3. PGC1alpha regulates FNDC5 and its proc (show FNDC5 Antibodies)essed (show BDNF Antibodies) and secreted peptide Irisin, which has been proposed to play a critical role in ene (show FNDC5 Antibodies)rgy expenditure (show FNDC5 Antibodies) and to promote neural differentiation of mouse embryonic stem cells. Review.

  4. PGC-1alpha control of reactive oxygen species homeostasis plays an important role in the regulation of de novo angiogenesis and is required for vascular stability.

  5. A novel role of PGC-1alpha in the development of hypertension

  6. PGC-1alpha overexpression contributes to enhanced neuronal viability by stimulating mitochondria number and respiration and increasing levels of OXPHOS proteins and the anti-apoptotic protein XIAP (show XIAP Antibodies).

  7. The PPARalpha (show PPARA Antibodies) and PGC-1alpha are closely involved in energy metabolism remodeling and apoptosis in cardiomyocytes.

  8. Data suggest that trans-cinnamaldehyde, dietary flavoring agent with suspected hypoglycemic effects, stimulates mitochondrial biogenesis in muscle fibers through up-regulation of gene expression of Pgc1a and Glut4 (show SLC2A4 Antibodies) (facilitated glucose transporter (show SLC2A12 Antibodies) 4).

  9. Findings suggest that PGC1alpha protects against hyperthermia by cooperating with HSF1 (show HSF1 Antibodies) in the induction of a transcriptional program devoted to the cellular protection from thermal insults.

  10. We conclude that overexpression of PGC-1alpha by in vivo transfection can inhibit activation of mitophagy pathway in the atrophying muscle caused by immobilization.

Pig (Porcine) Peroxisome Proliferator-Activated Receptor Gamma, Coactivator 1 alpha (PPARGC1A) interaction partners

  1. Transcription of the gene was detected in adipose, muscle, kidney, liver, brain, heart and adrenal gland tissues, which is in agreement with the function of PPARGC1A in adaptive thermogenesis.

  2. The purpose of this study was to screen for new single nucleotide polymorphisms in exon 8 of the porcine PPARGC1A gene and to test their possible association with production traits.

  3. impact of PPARGC1A on energy and lipid metabolism in vivo, through several downstream target genes

  4. The *2690T>C and *2864T>C polymorphisms in PPARGC1A can be used as genetic markers for selection toward improved meat quality.

  5. The c.-2894G>A polymorphism in the 5' upstream region of the porcine PPARGC1A gene can be used as a meaningful molecular marker for simultaneous improvement of lean meat production and quality traits.

  6. PPARGC1A may play a key role in down-regulating lipid deposition, and the SNPs with differential genotype distribution among three breeds may be related to gene expression and fat deposition.

  7. Polymorphisms in PPARGC1A and CAPNS1 (show CAPNS1 Antibodies) genes may affect meat quality traits.

Human Peroxisome Proliferator-Activated Receptor Gamma, Coactivator 1 alpha (PPARGC1A) interaction partners

  1. Recent findings on the PGC1alpha/FNDC5 (show FNDC5 Antibodies)/BDNF (show BDNF Antibodies) pathway and its role in neuroprotection, and the controversial promise of the FNDC5 (show FNDC5 Antibodies) peptide irisin (show FNDC5 Antibodies) as a mediator of the positive benefits of exercise are discussed. Review.

  2. Fenofibrate inhibited atrial metabolic remodeling in atrial fibrillation (AF) by regulating the PPAR-alpha (show PPARA Antibodies)/sirtuin 1 (show SIRT1 Antibodies)/PGC-1alpha pathway indicating a novel therapeutic strategy for AF

  3. Results showed that PPARGC1alpha DNA methylation (show HELLS Antibodies) levels in placenta likely contributes to mediate the relationship between maternal glycemia and cord blood leptin (show LEP Antibodies) levels.

  4. In the present study we assessed whether genetic variation in CYP19A1 (show CYP19A1 Antibodies) is associated with risk of BC in a case-control study group nested within the Danish "Diet, Cancer and Health" cohort (ncases = 687 and ncontrols = 687) and searched for gene-gene interaction between CYP19A1 (show CYP19A1 Antibodies) and PPARGC1A, and CYP19A1 (show CYP19A1 Antibodies) and PPARG (show PPARG Antibodies), and gene-alcohol and gene-NSAID interactions

  5. Methionine was the only essential amino acid that rapidly induced PGC-1alpha acetylation through activating the GCN5 acetyltransferase.

  6. Although primarily a nuclear protein (show RDBP Antibodies), Sirt1 (show SIRT1 Antibodies) deacetylation of PPARGC1A has been extensively implicated in metabolic control and mitochondrial biogenesis, which was proposed to partially underlie Sirt1 (show SIRT1 Antibodies) role in caloric restriction and impacts on longevity. (Review)

  7. were observed to be significantly increased in the PGC-1alpha group compared with the control group. These results indicate that PGC-1alpha is able to induce angiogenesis in hRVECs and retinas, and suggests that PGC-1alpha is a potential anti-angiogenic target in retinal neovascularization.

  8. Novel angiogenic agent COA-Cl induced activation of PGC-1alpha/ERRalpha/VEGF signaling pathway in fibroblasts.

  9. Suggest that neither plasma adrenaline nor muscle metabolic stress determines the magnitude of PGC-1alpha mRNA response in exercising human muscle.

  10. Combined speed endurance and endurance exercise amplify the exercise-induced PGC-1alpha and PDK4 (show PDK4 Antibodies) mRNA response in trained human muscle.

Cow (Bovine) Peroxisome Proliferator-Activated Receptor Gamma, Coactivator 1 alpha (PPARGC1A) interaction partners

  1. The PPARGC1A synonymous mutation c.396G>A significantly associated with body weight and average daily gain in Nanyang cattle at the adult age.

  2. PPARGC1A genotypes had a significant effect on lengths of calving interval and calving to conception interval, and the T allele was demonstrated to have an unfavourable effect on these traits.

  3. NO/protein kinase (show CDK7 Antibodies) G (PKG (show PRKG1 Antibodies))-dependent downregulation of PGC-1 alpha and the ROS (show ROS1 Antibodies) detoxification system in endothelial cells are mediated by the PI3K/Akt (show AKT1 Antibodies) signaling

  4. The effects of dietary fat components on the expression of PPAR-gamma (show PPARG Antibodies) AND PPAR-gamma coactivator 1 in cultured bovine preadipocytes are reported.

  5. genetic analysis of bovine PPARGC1A

  6. PPARGC1A was associated with a significant increase in milk protein (show CSN2 Antibodies) percentage in contrast to association results previously reported for the German Holstein population

PPARGC1A Antigen Profile

Protein Summary

The protein encoded by this gene is a transcriptional coactivator that regulates the genes involved in energy metabolism. This protein interacts with PPARgamma, which permits the interaction of this protein with multiple transcription factors. This protein can interact with, and regulate the activities of, cAMP response element binding protein (CREB) and nuclear respiratory factors (NRFs). It provides a direct link between external physiological stimuli and the regulation of mitochondrial biogenesis, and is a major factor that regulates muscle fiber type determination. This protein may be also involved in controlling blood pressure, regulating cellular cholesterol homoeostasis, and the development of obesity.

Gene names and symbols associated with PPARGC1A

  • peroxisome proliferator-activated receptor gamma, coactivator 1 alpha (PPARGC1A) antibody
  • peroxisome proliferative activated receptor, gamma, coactivator 1 alpha (Ppargc1a) antibody
  • peroxisome proliferator activated receptor gamma, coactivator 1 alpha (PPARGC-1) antibody
  • peroxisome proliferator-activated receptor gamma, coactivator 1 alpha (Ppargc1a) antibody
  • peroxisome proliferator-activated receptor gamma, coactivator 1 alpha (ppargc1a) antibody
  • A830037N07Rik antibody
  • AVPGC-1ALPHA antibody
  • ENSMUSG00000079510 antibody
  • Gm11133 antibody
  • LEM6 antibody
  • PGC-1 antibody
  • PGC-1(alpha) antibody
  • Pgc-1alpha antibody
  • PGC-1v antibody
  • PGC1 antibody
  • PGC1A antibody
  • Pgco1 antibody
  • Ppargc1 antibody
  • PPARGC1A antibody

Protein level used designations for PPARGC1A

peroxisome proliferator-activated receptor gamma, coactivator 1 alpha , PPAR-gamma coactivator , peroxisome proliferator activated receptor gamma coactivator-1 , PGC-1-alpha , PPAR Gamma Coactivator-1 , PPAR gamma coactivator variant form , PPAR-gamma coactivator 1-alpha , PPARGC-1-alpha , Pgc-1alphaa , peroxisome proliferator-activated receptor gamma coactivator 1-alpha , L-PGC-1alpha , ligand effect modulator-6 , peroxisome proliferator-activated receptor gamma coactivator 1 alpha transcript variant B4 , peroxisome proliferator-activated receptor gamma coactivator 1 alpha transcript variant B4-3ext , peroxisome proliferator-activated receptor gamma coactivator 1 alpha transcript variant B4-8a , peroxisome proliferator-activated receptor gamma coactivator 1 alpha transcript variant B5 , peroxisome proliferator-activated receptor gamma coactivator 1 alpha transcript variant B5-NT , peroxisome proliferative activated receptor, gamma, coactivator 1 , peroxisome proliferator activated receptor gamma coactivator 1 alpha , PGC-1alpha , peroxisome proliferative activated receptor gamma coactivator 1 , peroxisome proliferative activated receptor, gamma, coactivator 1 alpha , proliferator-activated receptor gamma coactivator 1 alpha , peroxisome proliferative activated receptor, gamma, coactivator 1, alpha , peroxisome-proliferator-activated receptor-gamma co-activator-1

GENE ID SPECIES
443270 Ovis aries
19017 Mus musculus
397013 Sus scrofa
10891 Homo sapiens
479127 Canis lupus familiaris
338446 Bos taurus
83516 Rattus norvegicus
100462892 Xenopus laevis
422815 Gallus gallus
100349219 Oryctolagus cuniculus
100721512 Cavia porcellus
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