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The protein encoded by PPRC1 is similar to PPAR-gamma coactivator 1 (PPARGC1/PGC-1), a protein that can activate mitochondrial biogenesis in part through a direct interaction with nuclear respiratory factor 1 (NRF1). Additionally we are shipping PPRC1 Kits (3) and and many more products for this protein.
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Human Polyclonal PPRC1 Primary Antibody for EIA, IHC (p) - ABIN954283
Vercauteren, Gleyzer, Scarpulla: Short hairpin RNA-mediated silencing of PRC (PGC-1-related coactivator) results in a severe respiratory chain deficiency associated with the proliferation of aberrant mitochondria. in The Journal of biological chemistry 2009
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these results indicated an elevated basal metabolic rate and lipid metabolic alteration of male Pprc1(+/-) mice on high-fat diet, suggesting the significant role of Pprc1 in controlling mitochondrial gene expression and energy metabolic processes
Homozygous deficient PPRC1 mice failed to form egg cylinders and died after implantation but before embryonic day 6.5, whereas mice heterozygous for PPRC1 were viable, fertile and indistinguishable from their wild-type littermates.
PRC is a negative regulator of endothelial inflammation; it negatively regulates endothelial adhesion of monocytes via inhibition of NF kappaB (show NFKB1 Antibodies) activity
A general role for PRC in the adaptive response to cellular dysfunction.
PRC has a role in the rapid modulation of metabolic functions in response to the status of the cell cycle
overexpression of the PRC pathway is responsible for mitochondrial proliferation in the context of thyroid oncocytoma
PGC-1 (show PPARGC1A Antibodies) has a role in regulating gluconeogenic genes along with HNF-4alpha (show HNF4A Antibodies) and SREBP-1 (show SREBF1 Antibodies)
This review focuses on the biologic and physiologic functions of the PGC-1 (show PPARGC1A Antibodies) coactivators, with particular emphasis on striated (show NSDHL Antibodies) muscle, liver, and other organ systems relevant to common diseases such as diabetes and heart failure.
Upregulation of PGC-1alpha (show PPARGC1A Antibodies) and PGC-1beta (show PPARGC1B Antibodies) in the colorectal tumor cells can be part of an adaptation mechanism to help overcome the severe consequences of mtDNA mutations on oxidative phosphorylation.
These results revealed that bile acid inhibits the promoter activity of PGC-1 (show PPARGC1A Antibodies) in an SHP (show LAMC1 Antibodies)-dependent manner.
Activation of the SIRT1 (show SIRT1 Antibodies)/PGC-1 (show PPARGC1A Antibodies) pathway, in a metabolic context promotes mitochondrial function and this pathway plays a role in neurodegerative disease. Review.
The results are consistent with a pathway whereby PRC regulates NRF-2 (show GABPA Antibodies)-dependent genes through a multiprotein complex involving HCF-1 (show HCFC1 Antibodies).
The protein encoded by this gene is similar to PPAR-gamma coactivator 1 (PPARGC1/PGC-1), a protein that can activate mitochondrial biogenesis in part through a direct interaction with nuclear respiratory factor 1 (NRF1). This protein has been shown to interact with NRF1. It is thought to be a functional relative of PPARGC1 that activates mitochondrial biogenesis through NRF1 in response to proliferative signals.
, peroxisome proliferator-activated receptor gamma coactivator-related protein 1
, PGC-1 related co-activator
, peroxisome proliferative activated receptor, gamma, coactivator-related 1