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Phenylalanine-tRNA Synthetase 2 (Mitochondrial) Proteins (FARS2)

Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. Additionally we are shipping Phenylalanine-tRNA Synthetase 2 (Mitochondrial) Antibodies (25) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
Mouse FARS2 FARS2 69955 Q99M01
FARS2 10667 O95363
Rat FARS2 FARS2 306879 Q6AYQ3
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Top Phenylalanine-tRNA Synthetase 2 (Mitochondrial) Proteins at antibodies-online.com

Showing 4 out of 5 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag 50 μg Log in to see 7 to 8 Days
$319.00
Details
HOST_Wheat germ Human GST tag 2 μg Log in to see 9 Days
$333.33
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   50 μg Log in to see 3 to 4 Days
$364.64
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

FARS2 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
,

Top referenced Phenylalanine-tRNA Synthetase 2 (Mitochondrial) Proteins

  1. Human FARS2 Protein expressed in Escherichia coli (E. coli) - ABIN667420 : Bullard, Cai, Demeler, Spremulli: Expression and characterization of a human mitochondrial phenylalanyl-tRNA synthetase. in Journal of molecular biology 1999 (PubMed)
    Show all 2 references for ABIN667420

More Proteins for Phenylalanine-tRNA Synthetase 2 (Mitochondrial) (FARS2) Interaction Partners

Human Phenylalanine-tRNA Synthetase 2 (Mitochondrial) (FARS2) interaction partners

  1. A newly identified missense mutation in FARS2 causes autosomal-recessive spastic paraplegia.

  2. this study expands the phenotypic spectrum of FARS2 related disease and emphasizes intragenic deletion in the list of causative mutations.

  3. the three FARS2 mutations directly impair aminoacylation function and stability of mtPheRS, leading to a decrease in overall tRNA charging capacity.

  4. Two phenylalanyl-tRNA synthetase variants Ser57Cys and Asp280Ser both display wild-type aminoacylation activity and stability with respect to their free energies of unfolding, but are less stable at low hydrogen-ion concentration (pH).

  5. Formation of the PheRS (show FARSA Proteins)-tRNAPhe complex in human mitochondria must be accompanied by considerable rearrangement of the anticodon binding domain upon tRNA binding.

  6. Mitochondrial and cytoplasmic phenylalanyl-tRNA synthetases (HsmtPheRS and HsctPheRS, respectively) catalyze direct attachment of m-Tyr (show TYR Proteins) to tRNA(Phe).

Phenylalanine-tRNA Synthetase 2 (Mitochondrial) (FARS2) Protein Profile

Protein Summary

Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. This gene encodes a phenylalanine-tRNA synthetase (PheRS) localized to the mitochondrion which consists of a single polypeptide chain, unlike the (alpha-beta)2 structure of the prokaryotic and eukaryotic cytoplasmic forms of PheRS. Structure analysis and catalytic properties indicate mitochondrial PheRSs may constitute a class of PheRS distinct from the enzymes found in prokaryotes and in the eukaryotic cytoplasm.

Gene names and symbols associated with FARS2

  • phenylalanine-tRNA synthetase 2 (mitochondrial) (Fars2)
  • phenylalanyl-tRNA synthetase 2, mitochondrial (FARS2)
  • phenylalanyl-tRNA synthetase 2, mitochondrial (Fars2)
  • 2810431B21Rik protein
  • 6720478K01Rik protein
  • COXPD14 protein
  • dJ520B18.2 protein
  • FARS1 protein
  • HSPC320 protein
  • PheRS protein

Protein level used designations for FARS2

pheRS , phenylalanine--tRNA ligase, mitochondrial , phenylalanine-tRNA synthetase 1 (mitochondrial) , phenylalanyl-tRNA synthetase, mitochondrial , dJ236A3.1 (phenylalanine-tRNA synthetase) , dJ520B18.2 (FARS1 (phenylalanine-tRNA synthetase)) , phenylalanine tRNA ligase 2, mitochondrial , phenylalanine translase , phenylalanine-tRNA synthetase 2 (mitochondrial)

GENE ID SPECIES
69955 Mus musculus
10667 Homo sapiens
488204 Canis lupus familiaris
505390 Bos taurus
306879 Rattus norvegicus
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