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PDC encodes a phosphoprotein, which is located in the outer and inner segments of the rod cells in the retina. Additionally we are shipping Phosducin Antibodies (27) and Phosducin Proteins (7) and many more products for this protein.
Phosducin regulates secretory activity in TT line of thyroid parafollicular C cells.
Data suggest that phosducin rs12402521 polymorphism is an important genetic predictor of obesity-related hypertension.
identification of Pdc (show PNKD ELISA Kits) as a gene for stress-induced hypertension offers new insights into the relationship between sympathetic nervous system activation, blood pressure regulation and genetic factors
Data suggest that the existence of a common epitope on the molecules of phosducin and beta-actin (show ACTB ELISA Kits) may reflect a topological similarity of a small region of their surfaces.
Can (show PNKD ELISA Kits)didate gene-based association studies in 2 different populations revealed several SNPs in the PDC gene to be associated with stress-dependent blood pressure phenotypes.
Phosducin mutations are not a major cause of dominant or recessive retinitis pigmentosa, Leber congenital amaurosis, or cone-rod degeneration.
SUMO-1 (show SUMO1 ELISA Kits) controls the protein stability and the biological function of phosducin.
the role of phosducin at the rod-to-rod bipolar cell (RBC (show CACNA1C ELISA Kits)) synapse
A major regulatory component responsible for setting the sensitivity of signal transmission between photoreceptors and ON-bipolar cells is confined to photoreceptors and that phosducin participates in the underlying molecular mechanism.
Pdc-/- mice displayed exaggerated increases in blood pressure in response to post-operative stress.
data suggest that phosducin action is based on the reduction of transducin (show GNAT1 ELISA Kits) affinity to the membranes of rod outer segments, achieved by keeping the transducin (show GNAT1 ELISA Kits) beta gamma subunits apart from the alpha subunit (show POLG ELISA Kits)
The increased retinal degeneration 1 (show PDE6B ELISA Kits) phosducin phosphorylation coincided with increased activation of calcium/calmodulin-activated protein kinase (show CDK7 ELISA Kits) II, which is known to utilize phosducin as a substrate.
phosducin has a role in regulating signaling in the rod outer segment compartment and there are distinct functions for phosphorylation sites 54 and 71
Phosducin does not contribute to adaptation mechanisms of the outer segment by dynamically controlling heterotrimer availability, but is necessary for maintaining normal transducin (show GNAT1 ELISA Kits) expression and therefore normal flash sensitivity in rods.
Dopamine and other light-dependent processes cooperatively regulate the diurnal rhythm of phosducin phosphorylation. Dopamine release in response to light and circadian clocks drives daily rhythms of protein phosphorylation in photoreceptor cells.
Transducin (show GNAT1 ELISA Kits) betagamma is a substrate of the ubiquitin-proteasome pathway and is protected following the light-dependent dissociation of transducin (show GNAT1 ELISA Kits) alphabetagamma by phosducin
results suggest a pivotal role of Ser (show SIGLEC1 ELISA Kits)-54 and Ser (show SIGLEC1 ELISA Kits)-73 phosphorylation in determining the interactions of phosducin with its binding partner G protein beta (show GNB3 ELISA Kits) gamma dimer
This gene encodes a phosphoprotein, which is located in the outer and inner segments of the rod cells in the retina. This protein may participate in the regulation of visual phototransduction or in the integration of photoreceptor metabolism. It modulates the phototransduction cascade by interacting with the beta and gamma subunits of the retinal G-protein transducin. This gene is a potential candidate gene for retinitis pigmentosa and Usher syndrome type II. Alternatively spliced transcript variants encoding different isoforms have been identified.
, 33 kDa phototransducing protein
, G beta gamma binding protein
, phosducin-like orphan protein
, rod photoreceptor 1
, MEKA protein
, Phototransducing protein, 33 kDa (phosducin)
, pdc gene for phosducin