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Phosducin-Like Proteins (PDCL)

Phosducin-like protein is a putative modulator of heterotrimeric G proteins. Additionally we are shipping Phosducin-Like Antibodies (38) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
PDCL 5132 P20941
PDCL 67466 Q9DBX2
Rat PDCL PDCL 64013 Q63737
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Top Phosducin-Like Proteins at antibodies-online.com

Showing 7 out of 7 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag 20 μg Log in to see 7 to 8 Days
$319.00
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Cow His tag   1 mg Log in to see 56 to 66 Days
$2,795.83
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   20 μg Log in to see 3 to 4 Days
$382.86
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

PDCL Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
,
Mouse (Murine)

Top referenced Phosducin-Like Proteins

  1. Human PDCL Protein expressed in Escherichia coli (E. coli) - ABIN1098636 : Thibault, Feng Wang, Charnas, Mirel, Barhite, Miles: Cloning and characterization of the rat and human phosducin-like protein genes: structure, expression and chromosomal localization. in Biochimica et biophysica acta 1999 (PubMed)
    Show all 2 references for ABIN1098636

More Proteins for Phosducin-Like (PDCL) Interaction Partners

Human Phosducin-Like (PDCL) interaction partners

  1. Phosducin (show PDC Proteins) regulates secretory activity in TT line of thyroid parafollicular C cells.

  2. PhLP1 binding stabilizes the Gbeta (show SUCLG2 Proteins) fold, disrupting interactions with CCT (show FLVCR2 Proteins) and releasing a PhLP1-Gbeta (show SUCLG2 Proteins) dimer for assembly with Ggamma.

  3. evidence of a generic mechanism, whereby the splicing of the PhLP gene could potentially and efficiently regulate the cellular levels of heterotrimeric G proteins.

  4. Data suggest that phosducin (show PDC Proteins) rs12402521 polymorphism is an important genetic predictor of obesity-related hypertension.

  5. identification of Pdc (show PNKD Proteins) as a gene for stress-induced hypertension offers new insights into the relationship between sympathetic nervous system activation, blood pressure regulation and genetic factors

  6. Data suggest that the existence of a common epitope on the molecules of phosducin (show PDC Proteins) and beta-actin (show ACTB Proteins) may reflect a topological similarity of a small region of their surfaces.

  7. Candidate gene-based association studies in 2 different populations revealed several SNPs in the PDC (show PNKD Proteins) gene to be associated with stress-dependent blood pressure phenotypes.

  8. physiological control of G-protein regulation by PhLP seems to involve phosphorylation by CK2 (show CSNK2A1 Proteins) and alternative splicing of the regulator

  9. the strong inhibitory action of PhLP(S) on Gbetagamma signaling is the result of a previously unrecognized mechanism of Gbetagamma-regulation, inhibition of Gbetagamma-folding by interference with TCP-1alpha (show TCP1 Proteins)

  10. PhLP phosphorylation permits the release of a PhLP x Gbeta (show SUCLG2 Proteins) intermediate from cytosolic chaperonin (show HSPD1 Proteins) complex, allowing Ggamma to associate with Gbeta (show SUCLG2 Proteins) in this intermediate complex.

Mouse (Murine) Phosducin-Like (PDCL) interaction partners

  1. findings reveal a common mechanism of Gbetagamma and RGS9-Gbeta5 assembly in rods and cones, highlighting the importance of PhLP1 and CCT-mediated Gbeta complex formation in G protein signaling.

  2. evidence of a generic mechanism, whereby the splicing of the PhLP gene could potentially and efficiently regulate the cellular levels of heterotrimeric G proteins.

  3. this study demonstrated in vivo that PhLP1 is required for the folding and assembly of both Gbetagamma and Gbeta5 (show GNB5 Proteins)-RGS9 (show RGS Proteins).

  4. These data are consistent with the hypothesis that PhLP is a widely expressed modulator of Gbetagamma function.

  5. These results suggest a mechanism for Gbetagamma assembly in which PhLP stabilizes the nascent Gbeta (show SUCLG2 Proteins) polypeptide until Ggamma can associate, resulting in membrane binding of Gbetagamma and release of PhLP to catalyze another round of assembly.

  6. N-glycosylated phosducin-like protein long (PhLP(L)) is expressed in all structures of the central nervous system and regulates opioid receptor function in the brain.

  7. identification of novel germ-like specific form in phosducin-like protein family

  8. physiological control of G-protein regulation by PhLP seems to involve phosphorylation by CK2 (show CSNK2A1 Proteins) and alternative splicing of the regulator

Cow (Bovine) Phosducin-Like (PDCL) interaction partners

  1. antagonistic actions of PhLP3 and prefoldin serve to modulate CCT activity and play a key role in establishing a functional cytoskeleton in vivo

Phosducin-Like (PDCL) Protein Profile

Protein Summary

Phosducin-like protein is a putative modulator of heterotrimeric G proteins. The protein shares extensive amino acid sequence homology with phosducin, a phosphoprotein expressed in retina and pineal gland. Both phosducin-like protein and phosphoducin have been shown to regulate G-protein signaling by binding to the beta-gamma subunits of G proteins.

Gene names and symbols associated with Phosducin-Like Proteins (PDCL)

  • phosducin-like (pdcl)
  • phosducin (PDC)
  • phosducin-like (PDCL)
  • phosducin-like (Pdcl)
  • 1200011E13Rik protein
  • AW108059 protein
  • MEKA protein
  • PHD protein
  • PhLOP protein
  • Phlp protein
  • PhLP1 protein

Protein level used designations for Phosducin-Like Proteins (PDCL)

phosducin-like , 33 kDa phototransducing protein , G beta gamma binding protein , phosducin-like orphan protein , phosducin-like protein , PHLP

GENE ID SPECIES
548824 Xenopus (Silurana) tropicalis
5132 Homo sapiens
5082 Homo sapiens
67466 Mus musculus
64013 Rattus norvegicus
286773 Bos taurus
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