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Phosducin-like protein is a putative modulator of heterotrimeric G proteins. Additionally we are shipping Phosducin-Like Antibodies (41) and many more products for this protein.
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Human PDCL Protein expressed in Escherichia coli (E. coli) - ABIN1098636
Thibault, Feng Wang, Charnas, Mirel, Barhite, Miles: Cloning and characterization of the rat and human phosducin-like protein genes: structure, expression and chromosomal localization. in Biochimica et biophysica acta 1999
Show all 2 references for ABIN1098636
Phosducin (show PDC Proteins) regulates secretory activity in TT line of thyroid parafollicular C cells.
PhLP1 binding stabilizes the Gbeta (show SUCLG2 Proteins) fold, disrupting interactions with CCT (show FLVCR2 Proteins) and releasing a PhLP1-Gbeta (show SUCLG2 Proteins) dimer for assembly with Ggamma.
evidence of a generic mechanism, whereby the splicing of the PhLP gene could potentially and efficiently regulate the cellular levels of heterotrimeric G proteins.
Data suggest that phosducin (show PDC Proteins) rs12402521 polymorphism is an important genetic predictor of obesity-related hypertension.
identification of Pdc (show PNKD Proteins) as a gene for stress-induced hypertension offers new insights into the relationship between sympathetic nervous system activation, blood pressure regulation and genetic factors
Data suggest that the existence of a common epitope on the molecules of phosducin (show PDC Proteins) and beta-actin (show ACTB Proteins) may reflect a topological similarity of a small region of their surfaces.
Candidate gene-based association studies in 2 different populations revealed several SNPs in the PDC (show PNKD Proteins) gene to be associated with stress-dependent blood pressure phenotypes.
physiological control of G-protein regulation by PhLP seems to involve phosphorylation by CK2 (show CSNK2A1 Proteins) and alternative splicing of the regulator
the strong inhibitory action of PhLP(S) on Gbetagamma signaling is the result of a previously unrecognized mechanism of Gbetagamma-regulation, inhibition of Gbetagamma-folding by interference with TCP-1alpha (show TCP1 Proteins)
PhLP phosphorylation permits the release of a PhLP x Gbeta (show SUCLG2 Proteins) intermediate from cytosolic chaperonin (show HSPD1 Proteins) complex, allowing Ggamma to associate with Gbeta (show SUCLG2 Proteins) in this intermediate complex.
findings reveal a common mechanism of Gbetagamma and RGS9-Gbeta5 assembly in rods and cones, highlighting the importance of PhLP1 and CCT-mediated Gbeta complex formation in G protein signaling.
this study demonstrated in vivo that PhLP1 is required for the folding and assembly of both Gbetagamma and Gbeta5 (show GNB5 Proteins)-RGS9 (show RGS Proteins).
These data are consistent with the hypothesis that PhLP is a widely expressed modulator of Gbetagamma function.
These results suggest a mechanism for Gbetagamma assembly in which PhLP stabilizes the nascent Gbeta (show SUCLG2 Proteins) polypeptide until Ggamma can associate, resulting in membrane binding of Gbetagamma and release of PhLP to catalyze another round of assembly.
N-glycosylated phosducin-like protein long (PhLP(L)) is expressed in all structures of the central nervous system and regulates opioid receptor function in the brain.
identification of novel germ-like specific form in phosducin-like protein family
antagonistic actions of PhLP3 and prefoldin serve to modulate CCT activity and play a key role in establishing a functional cytoskeleton in vivo
Phosducin-like protein is a putative modulator of heterotrimeric G proteins. The protein shares extensive amino acid sequence homology with phosducin, a phosphoprotein expressed in retina and pineal gland. Both phosducin-like protein and phosphoducin have been shown to regulate G-protein signaling by binding to the beta-gamma subunits of G proteins.
, 33 kDa phototransducing protein
, G beta gamma binding protein
, phosducin-like orphan protein
, phosducin-like protein