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The protein encoded by PHACTR3 is associated with the nuclear scaffold in proliferating cells. Additionally we are shipping Phosphatase and Actin Regulator 3 Proteins (5) and many more products for this protein.
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DNA methylation (show HELLS Antibodies) of phosphatase and actin regulator 3 is associated with colorectal cancer.
Because its expression is highest in relatively plastic regions of the adult brain (cortex, hippocampus), scapinin is a new regulator of neurite outgrowth and neuroplasticity in the brain.
E2F4, PHACTR3, PRAME family member and CDH12 most probably play important role in non-small-cell lung cancer geneses
scapinin is a putative regulatory subunit of PP1 (show PPA1 Antibodies) and is involved in transformed or immature phenotypes of HL-60 cells
scapinin enhances cell spreading and motility through direct interaction with actin and PP1 (show PPA1 Antibodies) plays a regulatory role in scapinin-induced morphological changes
Polymorphisms within the PHACTR3 gene are associated with meat color in the pig.
This study demonistrated that Phactr1 appeared to be expressed in post-mitotic neurons in developmental brain.
Phactr3 exon 1C splice variant is potentially strain specific regulated, leading to the expression of only one allele of the reciprocal crosses.
The protein encoded by this gene is associated with the nuclear scaffold in proliferating cells. It was found to bind to the catalytic subunit of protein phosphatase-1 (PP1) and inhibit PP1 activity, suggesting that this protein may function as a regulatory subunit of PP1. Alternative splicing at this locus results in several transcript variants encoding different isoforms.
phosphatase and actin regulator 3
, scaffold-associated PP1-inhibiting protein