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Phosphatidylcholine (PC) is the most abundant mammalian phospholipid. Additionally we are shipping PEMT Kits (6) and PEMT Proteins (4) and many more products for this protein.
Showing 10 out of 42 products:
Human Polyclonal PEMT Primary Antibody for EIA, WB - ABIN356555
Walkey, Shields, Vance: Identification of three novel cDNAs for human phosphatidylethanolamine N-methyltransferase and localization of the human gene on chromosome 17p11.2. in Biochimica et biophysica acta 1999
Show all 3 references for ABIN356555
Data show that phosphatidylethanolamineN-methyltransferase (PEMT) rs12325817 polymorphism only marginally changed the association value with academic achievement.
Data suggest that maternal dietary intake during lactation (here, choline intake exceeding dietary recommendations) can alter hepatic PEMT activity and increase choline content of breast milk.
MTHFR rs1801131 C allele and PEMT rs4646356 T allele were associated with a high risk of type 2 diabetes in Han Chinese.
The GG genotype of the PEMT G774C polymorphism, higher levels of serum homocysteine and lower levels of serum betaine are associated with an increased risk of microangiopathy in patients with diabetes.
PEMT is a functional single nucleotide polymorphism (rs7946) in PEMT with sporadic Alzheimer's disease risk in a Han Chinese population.
the PEMT -774G>C and CHDH (show CHDH Antibodies) +432G>T polymorphisms were associated with sperm concentration. This finding suggests a possible influence of these genes on sperm quality
genetic association studies on endometriosis in a population of women in Poland: Data suggest interaction between an SNP in PEMT (rs4244593) and an SNP in MTHFR (show MTHFR Antibodies) (Ala222Val; rs1801133) in infertile women with some indication of endometriosis.
nvestigation of factors affecting liver PEMT activity: PEMT activity is lower in liver samples from women who are homozygous for an SNP in PEMT (rs12325817)
allele-specific ablation of estrogen receptor (show ESR1 Antibodies)-DNA interaction in the PEMT locus prevents hormone-inducible PEMT expression, conferring risk of choline deficiency in women
Choline requirements for both women are increased by the genetic polymorphism rs12325817 in phosphatidylethanolamine-N-methyltransferase.
propose that cold-induced hypothermia in HF-fed Pemt(-/-) mice is linked to plasma hypoglycemia due to compromised hepatic glucose production.
Lack of PEMT in mice does not promote fatty acid oxidation in skeletal muscle.
Decreased lipogenesis in white adipose tissue may contribute to the resistance to diet-induced obesity in Pemt(-/-) mice.
these findings indicate that the inhibition of Pemt activity ameliorates the ER stress associated with diabetic nephropathy in a model of type 1 diabetes
This study evaluated the role of the role of phosphatidylethanolamine N-methyltransferase in hepatic carbohydrate metabolism in chow-fed mice.
Pemt deficiency results in attenuated secretion of very low-density lipoproteins and homocysteine as well as in increased susceptibility to nonalcoholic liver disease.
Lack of phosphatidylethanolamine N-methyltransferase decreased liver damage in Abcb4 (show ABCB4 Antibodies)(-/-) mice caused by exposure of the liver to excess bile acids.
Treatment strategies aimed at inhibition of PEMT might prevent the accumulation of cardiac triacylglycerol that predisposes individuals to compromised cardiac function.
de novo synthesis of choline via PEMT has a previously unappreciated role in regulating whole body energy metabolism.
During differentiation of 3T3-L1 cells to adipocytes, the amount of Sp1 (show SP1 Antibodies) protein decreased by approximately 50% just prior to activation of PEMT.
Phosphatidylcholine (PC) is the most abundant mammalian phospholipid. This gene encodes an enzyme which converts phosphatidylethanolamine to phosphatidylcholine by sequential methylation in the liver. Another distinct synthetic pathway in nucleated cells converts intracellular choline to phosphatidylcholine by a three-step process. The protein isoforms encoded by this gene localize to the endoplasmic reticulum and mitochondria-associated membranes. Alternate splicing of this gene results in multiple transcript variants encoding different isoforms.
, phospholipid methyltransferase family protein