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Phosphatidylinositol Binding clathrin Assembly Protein Proteins

(Phosphatidylinositol Binding clathrin Assembly Protein (PICALM))

This gene encodes a clathrin assembly protein, which recruits clathrin and adaptor protein complex 2 (AP2) to cell membranes at sites of coated-pit formation and clathrin-vesicle assembly. The protein may be required to determine the amount of membrane to be recycled, possibly by regulating the size of the clathrin cage. The protein is involved in AP2-dependent clathrin-mediated endocytosis at the neuromuscular junction. A chromosomal translocation t(10\;11)(p13\;q14) leading to the fusion of this gene and the MLLT10 gene is found in acute lymphoblastic leukemia, acute myeloid leukemia and malignant lymphomas. The polymorphisms of this gene are associated with the risk of Alzheimer disease. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2011].

recommended

PICALM Protein (AA 1-610) (GST tag) (ABIN1315001)

PICALM Origin: Human Host: Wheat germ Recombinant WB, ELISA, AP, AA

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recommended

PICALM Protein (AA 2-652) (His tag) (ABIN3086159)

Crystallography grade PICALM Origin: Human Host: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA, Crys

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recommended

PICALM Protein (AA 2-660) (His tag) (ABIN3135908)

Crystallography grade PICALM Origin: Mouse Host: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA, Crys

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Phosphatidylinositol Binding clathrin Assembly Protein Proteins by Grade

Find Phosphatidylinositol Binding clathrin Assembly Protein Proteins with a specific Grade. The Grade listed below are among those available. Click on a link to go to the corresponding products.

Phosphatidylinositol Binding clathrin Assembly Protein Proteins by Origin

Find Phosphatidylinositol Binding clathrin Assembly Protein Proteins for a variety of species such as anti-Human Phosphatidylinositol Binding clathrin Assembly Protein, anti-Mouse Phosphatidylinositol Binding clathrin Assembly Protein, anti-Rat Phosphatidylinositol Binding clathrin Assembly Protein. The species listed below are among those available. Click on a link to go to the corresponding products.

Phosphatidylinositol Binding clathrin Assembly Protein Proteins by Source

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Phosphatidylinositol Binding clathrin Assembly Protein Proteins by Protein Type

Here you can find Phosphatidylinositol Binding clathrin Assembly Protein Proteins proteins categorized by available protein types. Additional protein types can be located using our search function.

Phosphatidylinositol Binding clathrin Assembly Protein Proteins by Application

Find Phosphatidylinositol Binding clathrin Assembly Protein Proteins validated for a specific application such as ELISA, WB, SDS, Crys. Some of the available applications are listed below. Click on a link to go to the corresponding products.

Popular Phosphatidylinositol Binding clathrin Assembly Protein Proteins

Product

Reactivity

Source

Validations

Cat. No.

Quantity

Datasheet

PICALM Protein (AA 1-610) (GST tag)

Reactivity Human

Source Wheat germ

Validations

Cat. No. ABIN1315001

Quantity 10 μg

Datasheet Datasheet

PICALM Protein (AA 2-652) (His tag)

Reactivity Human

Source Insect Cells

Validations

Cat. No. ABIN3086159

Quantity 1 mg

Datasheet Datasheet

PICALM Protein (AA 2-660) (His tag)

Reactivity Mouse

Source Insect Cells

Validations

Cat. No. ABIN3135908

Quantity 1 mg

Datasheet Datasheet

PICALM Protein (Transcript Variant 1) (Myc-DYKDDDDK Tag)

Reactivity Human

Source HEK-293 Cells

Validations

Cat. No. ABIN2728884

Quantity 20 μg

Datasheet Datasheet

PICALM Protein (AA 19-285) (His tag)

Reactivity Human

Source Escherichia coli (E. coli)

Validations

Cat. No. ABIN7408408

Quantity 100 μg

Datasheet Datasheet

PICALM Protein (AA 2-640) (His tag)

Reactivity Rat

Source Yeast

Validations

Cat. No. ABIN1475689

Quantity 1 mg

Datasheet Datasheet

Latest Publications for our Phosphatidylinositol Binding clathrin Assembly Protein Proteins

Zhao, Sagare, Ma, Halliday, Kong, Kisler, Winkler, Ramanathan, Kanekiyo, Bu, Owens, Rege, Si, Ahuja, Zhu, Miller, Schneider, Maeda, Maeda, Sugawara, Ichida, Zlokovic: "Central role for PICALM in amyloid-β blood-brain barrier transcytosis and clearance." in: Nature neuroscience, Vol. 18, Issue 7, pp. 978-87, (2015) (PubMed).

Baig, Joseph, Tayler, Abraham, Owen, Williams, Kehoe, Love: "Distribution and expression of picalm in Alzheimer disease." in: Journal of neuropathology and experimental neurology, Vol. 69, Issue 10, pp. 1071-7, (2010) (PubMed).

Aliases for Phosphatidylinositol Binding clathrin Assembly Protein Proteins

leucine aminopeptidase 3 (LAP3) Proteins
phosphatidylinositol binding clathrin assembly protein (PICALM) Proteins
phosphatidylinositol binding clathrin assembly protein (Picalm) Proteins
si:ch211-200p22.4 (si:ch211-200p22.4) Proteins
CALM Proteins
Calm Proteins
CLTH Proteins
fit-1 Proteins
fit1 Proteins
LAP Proteins
LAP-3 Proteins
mKIAA4114 Proteins
PAP180 Proteins
PEPS Proteins

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Phosphatidylinositol Binding clathrin Assembly Protein Proteins by Grade

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Phosphatidylinositol Binding clathrin Assembly Protein Proteins by Application

Popular Phosphatidylinositol Binding clathrin Assembly Protein Proteins

Latest Publications for our Phosphatidylinositol Binding clathrin Assembly Protein Proteins

Aliases for Phosphatidylinositol Binding clathrin Assembly Protein Proteins

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