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Phosphatidylinositol-3,4,5-Trisphosphate-Dependent Rac Exchange Factor 1 (PREX1) ELISA Kits

The protein encoded by PREX1 acts as a guanine nucleotide exchange factor for the RHO family of small GTP-binding proteins (RACs). Additionally we are shipping PREX1 Antibodies (57) and and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
PREX1 57580 Q8TCU6
PREX1 277360 Q69ZK0
Anti-Rat PREX1 PREX1 311647  
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Top PREX1 ELISA Kits at antibodies-online.com

Showing 2 out of 3 products:

Catalog No. Reactivity Sensitivity Range Quantity Supplier Delivery Price Details
Human 0.156-10 ng/mL 96 Tests Log in to see 11 to 13 Days
$946.00
Details
Mouse
96 Tests Log in to see 11 to 13 Days
$946.00
Details

More ELISA Kits for PREX1 Interaction Partners

Human Phosphatidylinositol-3,4,5-Trisphosphate-Dependent Rac Exchange Factor 1 (PREX1) interaction partners

  1. P-Rex1 contributes to the spatiotemporal localization of type I PKA, which tightly regulates this guanine exchange factor by a multistep mechanism.

  2. findings suggest a vital role of P-Rex1 signaling in CA1 (show CA1 ELISA Kits) LTD that is critical for social behavior and cognitive function and offer new insight into the etiology of ASDs

  3. The P-Rex1-Rac1 interface is critical for Rac1 activation in breast cancer cells.

  4. P-REX1 promotes both PI3K (show PIK3CA ELISA Kits)/AKT (show AKT1 ELISA Kits) and MEK (show MAP2K1 ELISA Kits)/ERK (show EPHB2 ELISA Kits) signaling in breast cancer.

  5. PREX1 gene promoter hypomethylation is a prognostic marker of poor patient survival.

  6. Phosphorylation of P-Rex1 at serine 1169 participates in IGF-1R (show IGF1R ELISA Kits) signaling in breast cancer cells.

  7. Cucurbitacin I also failed to affect the activation of P-Rex1 by heregulin (show NRG1 ELISA Kits).

  8. These data suggest that P-Rex1 has an influence on physiological migratory processes, such as invasion of cancer cells, both through effects upon classical Rac1-driven motility and a novel association with RTK signalling complexes.

  9. Studies indicate relevance of P-Rex1 and P-Rex2a, in breast tumorigenesis, and suggest that the exchange factors Vav2 (show VAV2 ELISA Kits) and Vav3 (show VAV3 ELISA Kits) play synergistic roles in breast cancer by sustaining tumor growth, neoangiogenesis, and metastasis.

  10. We have identified a novel mechanism for direct activation of P-Rex1 through PP1alpha (show PPP1CA ELISA Kits)-dependent dephosphorylation.

Mouse (Murine) Phosphatidylinositol-3,4,5-Trisphosphate-Dependent Rac Exchange Factor 1 (PREX1) interaction partners

  1. A novel mechanism of P-Rex1 regulation through the GPCR (show GPBAR1 ELISA Kits)-adaptor protein Norbin (show NCDN ELISA Kits).

  2. Tiam1 and P-Rex1 promote Rac1 anti- and pro-migratory signalling cascades.

  3. findings suggest a vital role of P-Rex1 signaling in CA1 (show CA1 ELISA Kits) LTD that is critical for social behavior and cognitive function and offer new insight into the etiology of ASDs

  4. regulates GPCR-driven Rac signalling and actin polarity in neutrophils

  5. Platelet P-Rex and Vav (show VAV1 ELISA Kits) family Rac (show AKT1 ELISA Kits)-GEFs play important proinflammatory roles in leukocyte recruitment.

  6. We have elucidated a proliferative role of P-Rex1 when Rac1 is deleted in melanoblasts.

  7. P-Rex1 may serve as a biomarker to predict response to single-agent PI3K inhibitors within a subset of breast cancers.

  8. In vivo, in an ischemia-reperfusion-induced model of acute kidney injury, abolished selectin-mediated integrin activation contributed to decreased neutrophil recruitment and reduced kidney damage in P-Rex1-deficient mice.

  9. P-rex1 expressed in endothelial cells is a critical mediator of vascular barrier disruption by an upstream pathway.

  10. Data conclude that P-Rex1 has an important role in melanoblast migration and cancer progression to metastasis in mice and humans.

PREX1 Antigen Profile

Antigen Summary

The protein encoded by this gene acts as a guanine nucleotide exchange factor for the RHO family of small GTP-binding proteins (RACs). It has been shown to bind to and activate RAC1 by exchanging bound GDP for free GTP. The encoded protein, which is found mainly in the cytoplasm, is activated by phosphatidylinositol-3,4,5-trisphosphate and the beta-gamma subunits of heterotrimeric G proteins.

Gene names and symbols associated with PREX1

  • phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1 (prex1) antibody
  • phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1 (PREX1) antibody
  • phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1 (Prex1) antibody
  • G630042G04 antibody
  • MGC68772 antibody
  • P-REX1 antibody
  • RGD1306534 antibody
  • Setd6 antibody

Protein level used designations for PREX1

phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1 , phosphatidylinositol 3,4,5-trisphosphate-dependent RAC exchanger 1 , phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein-like , phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein , ptdIns(3,4,5)-dependent Rac exchanger 1 , SET domain containing 6

GENE ID SPECIES
399069 Xenopus laevis
419210 Gallus gallus
714351 Macaca mulatta
100029404 Monodelphis domestica
100075289 Ornithorhynchus anatinus
100220665 Taeniopygia guttata
100357266 Oryctolagus cuniculus
100436617 Pongo abelii
100467037 Ailuropoda melanoleuca
100488039 Xenopus (Silurana) tropicalis
100564517 Anolis carolinensis
100601640 Nomascus leucogenys
57580 Homo sapiens
485917 Canis lupus familiaris
527410 Bos taurus
277360 Mus musculus
311647 Rattus norvegicus
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