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Phosphatidylinositol-5-Phosphate 4-Kinase, Type II, alpha Proteins (PIP4K2A)

Phosphatidylinositol-5,4-bisphosphate, the precursor to second messengers of the phosphoinositide signal transduction pathways, is thought to be involved in the regulation of secretion, cell proliferation, differentiation, and motility. Additionally we are shipping PIP4K2A Antibodies (80) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
PIP4K2A 5305 P48426
PIP4K2A 18718 O70172
PIP4K2A 116723 Q9R0I8
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Top PIP4K2A Proteins at antibodies-online.com

Showing 8 out of 9 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Wild boar His tag   1 mg Log in to see 56 to 66 Days
$3,122.17
Details
Yeast Chicken His tag   1 mg Log in to see 56 to 66 Days
$3,122.17
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$3,122.17
Details
HOST_Baculovirus infected Insect Cells Human GST tag   5 μg Log in to see 10 to 12 Days
$322.08
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

PIP4K2A Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
,
Mouse (Murine)

Rat (Rattus)

More Proteins for Phosphatidylinositol-5-Phosphate 4-Kinase, Type II, alpha (PIP4K2A) Interaction Partners

Human Phosphatidylinositol-5-Phosphate 4-Kinase, Type II, alpha (PIP4K2A) interaction partners

  1. PIP5K2A is possibly involved in a mechanism protecting against tardive dyskinesia-inducing neurotoxicity.

  2. The diplotype ATTGCT/ATTGCT of the PIP4K2A gene confers approximately three-times higher incomplete responsiveness towards antipsychotics in severely ill patients.

  3. PIP4K2A to be essential for the clonogenic and leukemia-initiating potential of human AML (show RUNX1 Proteins) cells, and for the clonogenic potential of murine MLL (show MLL Proteins)-AF9 (show MLLT3 Proteins) AML (show RUNX1 Proteins) cells.

  4. We also showed that PIPKIIalpha silencing can induce alpha and gamma globin expression and decrease cell proliferation in K562 cells.

  5. Overexpression of type 2A PI(4)P5-kinase (PIP5K (show PIKFYVE Proteins) 2A) significantly reduced tamoxifen inhibition of Kv7.2 (show KCNQ2 Proteins)/Kv7.3 and Kv7.2 (show KCNQ2 Proteins) R463Q channels.

  6. The data suggest that PI5P4Ka N251S does not significantly differ in activity from the wild-type enzyme, throwing a new light on its association with schizophrenia.

  7. Knocking down PI5P4Kalpha and beta in a breast cancer cell line bearing an amplification of the gene encoding PI5P4K beta and deficient for p53 (show TP53 Proteins) impaired growth on plastic and in xenografts.

  8. Variation at 10p12.2 (PIP4K2A) and 10p14 (GATA3 (show GATA3 Proteins)) influences risk of acute lymphoblastic anemia and tumor subtype. (Meta-analysis)

  9. PIP5K2A variant influences susceptibility to schizophrenia in the Russian population of Siberia. Authors studied 355 patients with schizophrenic disorders from the Russian population of Siberia.

  10. The present study demonstrated that expression of PIP4K2A mRNA is significantly increased in LCL derived from patients with schizophrenia

Mouse (Murine) Phosphatidylinositol-5-Phosphate 4-Kinase, Type II, alpha (PIP4K2A) interaction partners

  1. PIP4K2A to be essential for the clonogenic and leukemia-initiating potential of human AML (show RUNX1 Proteins) cells, and for the clonogenic potential of murine MLL (show MLL Proteins)-AF9 (show MLLT3 Proteins) AML (show RUNX1 Proteins) cells.

PIP4K2A Protein Profile

Protein Summary

Phosphatidylinositol-5,4-bisphosphate, the precursor to second messengers of the phosphoinositide signal transduction pathways, is thought to be involved in the regulation of secretion, cell proliferation, differentiation, and motility. The protein encoded by this gene is one of a family of enzymes capable of catalyzing the phosphorylation of phosphatidylinositol-5-phosphate on the fourth hydroxyl of the myo-inositol ring to form phosphatidylinositol-5,4-bisphosphate. The amino acid sequence of this enzyme does not show homology to other kinases, but the recombinant protein does exhibit kinase activity. This gene is a member of the phosphatidylinositol-5-phosphate 4-kinase family.

Gene names and symbols associated with PIP4K2A

  • phosphatidylinositol-5-phosphate 4-kinase, type II, alpha (PIP4K2A)
  • phosphatidylinositol-5-phosphate 4-kinase type-2 alpha-like (PIP4K2A)
  • phosphatidylinositol-5-phosphate 4-kinase, type II, alpha (pip4k2a)
  • phosphatidylinositol-5-phosphate 4-kinase, type II, alpha (Pip4k2a)
  • AW742916 protein
  • PI5P4KA protein
  • Pip5k2a protein
  • PIP5KII-alpha protein
  • PIP5KIIA protein
  • PIPK protein

Protein level used designations for PIP4K2A

phosphatidylinositol-4-phosphate 5-kinase, type II, alpha , phosphatidylinositol-4-phosphate 5-kinase type II alpha , pip5kii-alpha , 1-phosphatidylinositol 5-phosphate 4-kinase 2-alpha , 1-phosphatidylinositol-4-phosphate kinase , 1-phosphatidylinositol-4-phosphate-5-kinase , 1-phosphatidylinositol-5-phosphate 4-kinase 2-alpha , PI(5)P 4-kinase type II alpha , PIP4KII-alpha , PIP5KIII , PIP5KIIalpha , PtdIns(4)P-5-kinase B isoform , diphosphoinositide kinase 2-alpha , phosphatidylinositol 5-phosphate 4-kinase type II alpha , phosphatidylinositol 5-phosphate 4-kinase type-2 alpha , phosphatidylinositol-5-phosphate 4-kinase type-2 alpha , ptdIns(4)P-5-kinase C isoform , ptdIns(5)P-4-kinase isoform 2-alpha , type II phosphatidylinositol-4-phosphate 5-kinase 53 K isoform , 1-phosphatidylinositol-5-phosphate 4-kinase A , PIPK2 alpha , phosphatidylinositol-4-phosphate-5-kinase , phosphatidylinositol-5-phosphate 4-kinase type II alpha

GENE ID SPECIES
608414 Canis lupus familiaris
710724 Macaca mulatta
742458 Pan troglodytes
100036841 Xenopus laevis
100380045 Xenopus (Silurana) tropicalis
5305 Homo sapiens
18718 Mus musculus
116723 Rattus norvegicus
420504 Gallus gallus
100520446 Sus scrofa
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