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PDE4D3 encodes one of four mammalian counterparts to the fruit fly 'dunce' gene. Additionally we are shipping and many more products for this protein.
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Rat (Rattus) Polyclonal PDE4D3 Primary Antibody for ELISA, WB - ABIN190895
Houslay, Baillie, Maurice: cAMP-Specific phosphodiesterase-4 enzymes in the cardiovascular system: a molecular toolbox for generating compartmentalized cAMP signaling. in Circulation research 2007
This review show PDE4D (show PDE4D Antibodies) mutation is a risk factor for atrial fibrillation and stroke.
In this article, we review the role of the cAMP signal transduction pathway in memory formation with a particular focus on the recent progress in PDE4D (show PDE4D Antibodies) research
Aberrant DNA methylation (show HELLS Antibodies) of PDE4D (show PDE4D Antibodies) promoter alters airway smooth muscle cell phenotypes.
PDE4D (show PDE4D Antibodies) interacts directly with Neuropilins, positive regulators of Hedgehog (show SHH Antibodies) signal transduction pathway.
results suggest that the rs918592 and rs2910829 polymorphisms and haplotypes of PDE4D (show PDE4D Antibodies) gene are significantly associated with ischemic stroke in Chinese young population.
The increase in the C allele frequency at 87 single nucleotide polymorphism sites in PDE4D (show PDE4D Antibodies) may increase ischemic stroke risk.
Critical residues stabilising PDE4D5 dimerization were defined within the regulatory UCR1 region found in long, but not short, PDE4 isoforms, namely the Arg(173), Asn(174) and Asn(175) (DD1) cluster.
These studies suggest the pharmacologic inhibition of PDE4D (show PDE4D Antibodies) using small-molecule inhibitors is an effective option for prostate cancer therapy.
This result supports that PDE4D (show PDE4D Antibodies) polymorphisms might be involved in the susceptibility to COPD (show ARCN1 Antibodies) especially in non-emphysematous individuals and that they could also affect the responsiveness of the PDE4 (show PDE4A Antibodies) inhibitor treatment.
structural analysis of the autoinhibited conformation of PDE4 (show PDE4A Antibodies)
This gene encodes one of four mammalian counterparts to the fruit fly 'dunce' gene. The encoded protein has 3',5'-cyclic-AMP phosphodiesterase activity and degrades cAMP, which acts as a signal transduction molecule in multiple cell types. This gene uses different promoters to generate multiple alternatively spliced transcript variants that encode functional proteins.
cAMP-specific 3',5'-cyclic phosphodiesterase 4D
, cAMP-specific phosphodiesterase PDE4D6
, phosphodiesterase 4D, cAMP-specific (phosphodiesterase E3 dunce homolog, Drosophila)