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Phosphogluconate Dehydrogenase Proteins (PGD)

6-phosphogluconate dehydrogenase is the second dehydrogenase in the pentose phosphate shunt. Additionally we are shipping PGD Antibodies (70) and PGD Kits (6) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
PGD 236539 Q61753
PGD 5226 P52209
PGD 362660  
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Top PGD Proteins at antibodies-online.com

Showing 10 out of 18 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 7 to 8 Days
$286.00
Details
HOST_Escherichia coli (E. coli) Human GST tag 50 μg Log in to see 21 to 26 Days
$341.00
Details
HOST_Escherichia coli (E. coli) Human GST tag Phosphogluconate Dehydrogenase (PGD) (AA 4-483), (partial) protein (GST tag) 1 mg Log in to see 56 to 66 Days
$1,842.50
Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 16 Days
$327.80
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Wild boar His tag   1 mg Log in to see 56 to 66 Days
$2,641.83
Details
Yeast Fruit Fly His tag   1 mg Log in to see 56 to 66 Days
$3,358.67
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$3,362.33
Details

PGD Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human , ,
,
Rat (Rattus)

Top referenced PGD Proteins

  1. Human PGD Protein expressed in Escherichia coli (E. coli) - ABIN666961 : Le, Shirai, Okamoto, Tatsukawa, Nagao, Shimizu, Ito: Lipid signaling in cytosolic phospholipase A2alpha-cyclooxygenase-2 cascade mediates cerebellar long-term depression and motor learning. in Proceedings of the National Academy of Sciences of the United States of America 2010 (PubMed)
    Show all 2 references for ABIN666961

More Proteins for Phosphogluconate Dehydrogenase (PGD) Interaction Partners

Mouse (Murine) Phosphogluconate Dehydrogenase (PGD) interaction partners

  1. These results indicate that the PHGDH (show PHGDH Proteins) gene expression, dictated by IL-2R signaling, is a crucial event for DNA synthesis during S phase of activated T cells.

  2. Using transgenic mice expressing enhanced GFP under the Srr (show SRR Proteins) promoter and mice with targeted deletion of Srr (show SRR Proteins) or 3-Phosphoglycerate dehydrogenase (show PHGDH Proteins), we demonstrate predominantly neuronal sources of d-serine dependent on astrocytic supply of l-serine.

  3. Elevated levels of 4E-BP1 (show EIF4EBP1 Proteins) may be involved in a mechanism to arrest brain development in Phgdh (show PHGDH Proteins) knock out embryos.

  4. Glycolytic cancer cells lacking 6-phosphogluconate dehydrogenase metabolize glucose to induce senescence

  5. Phgdh (show PHGDH Proteins) deletion reveals a pivotal role for L-serine biosynthesis in controlling the level of brain D-serine, an N-methyl-D-aspartate receptor (show GRIN1 Proteins) co-agonist

  6. Data suggest expression of Phgdh (show PHGDH Proteins) in endometrium is regulated by Hoxa10 (show HOXA10 Proteins).

  7. Taken together, these data suggest that ADD1/SREBP1c (show SREBF1 Proteins) is a key transcription factor for 6PGDH gene expression and would coordinate glucose metabolism and lipogenesis for energy homeostasis.

  8. the Phgdh (show PHGDH Proteins)-dependent phosphorylated pathway is essential for normal embryonic development, especially for brain morphogenesis

  9. the presence of cis (show CISH Proteins)-acting elements confer the cell type specificity of Phgdh (show PHGDH Proteins) transcription in the distal promoter region.

  10. The mouse Phgdh (show PHGDH Proteins) gene spans approximately 27 kilobases in length and comprises 12 exons with 11 intervening introns and is mapped to chromosome 3, region F2-F3 by FISH.

Human Phosphogluconate Dehydrogenase (PGD) interaction partners

  1. Studies indicate link between the 6-phosphogluconate dehydrogenase, oxidative pentose phosphate pathway (PPP) and lipogenesis through Ru-5-P-dependent inhibition of serine/threonine protein kinase LKB1 (show STK11 Proteins)-AMPK (show PRKAA1 Proteins) signalling.

  2. copy number gain of the PGD gene was consistently identified in cervical cancers but not in the normal tissues

  3. Results show that 6PGD activity is upregulated with increased lysine acetylation in primary leukemia cells from human patients, providing mechanistic insights into 6PGD upregulation in cancer cells.

  4. Expression of 6PGD positively correlates with advancing stage of lung carcinoma. Knockdown of 6PGD by shRNA potently inhibits c-Met tyrosine phosphorylation.

  5. Glycolytic cancer cells lacking 6-phosphogluconate dehydrogenase metabolize glucose to induce senescence

  6. Data suggest that the affinity of Nox2 (show CYBB Proteins) for NADPH (show NQO1 Proteins) is increased in the presence of 6PGDH on cell stimulation.

  7. Hsa (show CD24 Proteins)-miR (show MLXIP Proteins)-132 and -212 were negatively correlated with PGD in the prefrontal cortex of individuals affected with schizophrenia and bipolar disorders.

PGD Protein Profile

Protein Summary

6-phosphogluconate dehydrogenase is the second dehydrogenase in the pentose phosphate shunt. Deficiency of this enzyme is generally asymptomatic, and the inheritance of this disorder is autosomal dominant. Hemolysis results from combined deficiency of 6-phosphogluconate dehydrogenase and 6-phosphogluconolactonase suggesting a synergism of the two enzymopathies.

Gene names and symbols associated with PGD

  • Phosphogluconate dehydrogenase (Pgd)
  • phosphogluconate dehydrogenase (pgd)
  • phosphogluconate hydrogenase (pgd)
  • phosphogluconate dehydrogenase (PGD)
  • 6-phosphogluconate dehydrogenase, decarboxylating (GND1a|GND1b)
  • 6-phosphogluconate dehydrogenase, decarboxylating (Thal_1580)
  • 6-phosphogluconate dehydrogenase, decarboxylating (GY4MC1_3101)
  • 6-phosphogluconate dehydrogenase, decarboxylating (Odosp_2189)
  • 6-phosphogluconate dehydrogenase, decarboxylating (Marky_1024)
  • 6-phosphogluconate dehydrogenase, decarboxylating (gnd)
  • 3-phosphoglycerate dehydrogenase (Phgdh)
  • 6-phosphogluconate dehydrogenase, decarboxylating-like (LOC101451876)
  • phosphogluconate dehydrogenase (Pgd)
  • 3-PGDH protein
  • 3PGDH protein
  • 6-pgd protein
  • 6-PGDH protein
  • 6Pgd protein
  • 6pgdh protein
  • 0610042A05Rik protein
  • 4930479N23 protein
  • A7 protein
  • A10 protein
  • AU019875 protein
  • C78335 protein
  • Cc2-27 protein
  • CG3724 protein
  • Dmel\\CG3724 protein
  • EG:87B1.4 protein
  • fi03d03 protein
  • GND1b protein
  • l(1)2Dc protein
  • l(1)2De protein
  • l(1)A7 protein
  • l(1)G0385 protein
  • l(1)N1 protein
  • l(1)N3[90] protein
  • l(1)Pgd protein
  • l(1)Pgd-A protein
  • l35 protein
  • N1 protein
  • Pdg protein
  • PGAD protein
  • Pgd protein
  • PGDH protein
  • SERA protein
  • wu:fi03d03 protein
  • zgc:55585 protein
  • zgc:111848 protein

Protein level used designations for PGD

6-phosphogluconate , 6-phosphogluconate dehydrogenase , CG3724-PA , CG3724-PB , NADP-6 phosphogluconate dehydrogenase , Pgd-PA , Pgd-PB , dehydrogenase , phosphogluconate dehydrogenase , 6-phosphogluconate dehydrogenase, decarboxylating , 3-phosphoglycerate dehyrogenase , D-3-phosphoglycerate dehydrogenase , 6-phosphogluconate dehydrogenase (decarboxylating)

GENE ID SPECIES
31185 Drosophila melanogaster
398848 Xenopus laevis
406762 Danio rerio
419450 Gallus gallus
514939 Bos taurus
5722476 Chlamydomonas reinhardtii
8815110 Thermocrinis albus DSM 14484
9929981 Geobacillus sp. Y4.1MC1
10253936 Odoribacter splanchnicus DSM 220712
10433922 Marinithermus hydrothermalis DSM 14884
10448388 Chlamydophila pecorum E58
100534626 Taeniopygia guttata
100598383 Nomascus leucogenys
236539 Mus musculus
101451876 Ceratitis capitata
5226 Homo sapiens
110208 Mus musculus
362660 Rattus norvegicus
397546 Sus scrofa
443541 Ovis aries
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