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anti-Phospholamban (PLN) Antibodies

The protein encoded by PLN is found as a pentamer and is a major substrate for the cAMP-dependent protein kinase in cardiac muscle. Additionally we are shipping Phospholamban Kits (48) and Phospholamban Proteins (6) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
PLN 5350 P26678
PLN 18821 P61014
PLN 64672 P61016
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Top anti-Phospholamban Antibodies at antibodies-online.com

Showing 10 out of 124 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Goat Un-conjugated EIA, WB AP21293PU-N PLN antibody staining of Human Heart lysate at 0.03 µg/ml (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. 0.1 mg Log in to see 6 to 8 Days
$379.50
Details
Human Rabbit Un-conjugated WB Western blot analysis of lysate from U266 cell line,using PLN Antibody (N-term) (ABIN1882182). AP20550a was diluted at 1:1000 at each lane. A goat anti-rabbit IgG H&L(HRP) at 1:5000 dilution was used as the secondary antibody. Lysate at 35ug per lane. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated WB Western blot with Phospholamban Polyclonal Antibody 0.1 mg Log in to see 6 to 8 Days
$313.50
Details
Human Rabbit Un-conjugated FACS, IHC (p), WB Flow cytometric analysis of Jurkat cells using PLB-Thr17 Cat.-No AP53332PU-N (bottom histogram) compared to a negative control cell (top histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis Immunohistochemistry analysis in formalin fixed and paraffin embedded mouse heart tissue using PLB-Thr17 followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the PLB-T17 Antibody for immunohistochemistry. Clinical relevance has not been evaluated. 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated WB Anti- PLN Picoband antibody, Western blotting All lanes: Anti PLN  at 0.5ug/ml Lane 1: Mouse Cardiac Muscle Tissue Lysate at 50ug Lane 2: Rat Cardiac Muscle Tissue Lysate at 50ug Lane 3: COLO320 Whole Cell Lysate at 40ug Lane 4: K562 Whole Cell Lysate at 40ug Predicted bind size: 6KD Observed bind size: 18, 24, 36KD 100 μg Log in to see 4 to 6 Days
$240.00
Details
Human Rabbit Un-conjugated IF, ELISA Immunofluorescence analysis of HuvEc cells, using PLB (Phospho-Ser16+Thr17) Antibody. The picture on the right is treated with the synthesized peptide. 100 μg Log in to see 2 to 3 Days
$302.50
Details
Human Rabbit Un-conjugated IF, ELISA Immunofluorescence analysis of HeLa cells, using PLB (Ab-16/17) Antibody. The picture on the right is treated with the synthesized peptide. 100 μg Log in to see 2 to 3 Days
$302.50
Details
Human Rabbit Un-conjugated DB Dot blot analysis of anti-Phospho-PLB-T17 Phospho-specific Pab (ABIN650834) on nitrocellulose membrane.  50 ng of Phospho-peptide or Non Phospho-peptide per dot were adsorbed. Antibody working concentrations are 0.5 µg/mL. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Goat Un-conjugated ELISA, WB 0.1 mg Log in to see 2 to 3 Days
$433.13
Details
Human Goat Un-conjugated IHC (p), ELISA, WB 50 μg Log in to see 8 to 10 Days
$451.00
Details

PLN Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-Phospholamban Antibodies

  1. Human Polyclonal Phospholamban Primary Antibody for WB - ABIN1882182 : Fujii, Zarain-Herzberg, Willard, Tada, MacLennan: Structure of the rabbit phospholamban gene, cloning of the human cDNA, and assignment of the gene to human chromosome 6. in The Journal of biological chemistry 1991 (PubMed)
    Show all 4 references for ABIN1882182

  2. Cow (Bovine) Polyclonal Phospholamban Primary Antibody for EIA, WB - ABIN499141 : Møller, Pham, Gustafsson, Hedley, Ersbøll, Bundgaard, Andersen, Torp-Pedersen, Køber, Christiansen: The role of Lamin A/C mutations in Danish patients with idiopathic dilated cardiomyopathy. in European journal of heart failure 2009 (PubMed)

More Antibodies against Phospholamban Interaction Partners

Human Phospholamban (PLN) interaction partners

  1. PLN may be a key molecular player in rigid substrate-induced cellular hypertrophy in eosinophilic esophagitis.

  2. These data suggest that PLN is, at least partially, oligo-ubiquitinated at Lys (show LYZ Antibodies)(3) and degraded through Ser (show SIGLEC1 Antibodies)(16)-phosphorylation-mediated poly-ubiquitination during heart failure.

  3. hereditary mutants of phospholamban are associated with heart failure [review]

  4. PLN pentamers reduce phosphorylation of monomers at baseline and delay monomer phosphorylation upon PKA stimulation leading to increased interaction of PLN monomers with SERCA2a (show ATP2A2 Antibodies).

  5. Phospholamban R14del mutation carriers are at high risk for malignant ventricular arrhythmias and end-stage heart failure, with left ventricular ejection fraction <45% and sustained or nonsustained ventricular tachycardia as independent risk factors.

  6. Although SLN (show SLN Antibodies) and PLB binding to SERCA (show ATP2A3 Antibodies) have different functional outcomes on the coupling efficiency of SERCA (show ATP2A3 Antibodies), both proteins decrease the apparent Ca(2 (show CA2 Antibodies)+) affinity of the pump, suggesting that SLN (show SLN Antibodies) and PLB inhibit SERCA (show ATP2A3 Antibodies) by using a similar mechanism.

  7. Phospholamban, and its interacting partners, regulates excitation contraction coupling and myocardial contraction. [Review]

  8. PLN mutations rarely cause cardiomyopathy

  9. analysis of how the conformational dynamics of protein kinase A induced by a lethal mutant of phospholamban hinder phosphorylation

  10. Aim of the present study is to determine the exact pattern of fibrosis and fatty replacement in PLN p.Arg14del mutation positive patients.

Pig (Porcine) Phospholamban (PLN) interaction partners

  1. Phosphorylation of PLB induces spatial rearrangements between the N- and P-domain elements of proximal Ca-ATPase (show CA-P60A Antibodies).

  2. Molecular dynamics simulations of phospholamban in solution and in membrane bilayer show two main features: the presence of two well-defined helical domains at the N- and C-termini, and large-amplitude rigid-body motions of these domains.

  3. The expression of SLN (show SLN Antibodies) and PLB mRNA and protein relative to SERCA1 (show ATP2A1 Antibodies) or SERCA2 (show ATP2A2 Antibodies) was assessed in ventricle, atrium, and skeltal msucle of mouse, rat, rabbit and pig.

Mouse (Murine) Phospholamban (PLN) interaction partners

  1. These data suggest that PLN is, at least partially, oligo-ubiquitinated at Lys (show LYZ Antibodies)(3) and degraded through Ser (show SIGLEC1 Antibodies)(16)-phosphorylation-mediated poly-ubiquitination during heart failure.

  2. the commercially available overexpressing phospholamban mouse phenotypically resembles human Centronuclear myopathy and could be used as a model to test potential mechanisms and therapeutic strategies.

  3. Cardioprotective effects of H2S are mediated through acGMP/PKG (show PRKG1 Antibodies)/phospholamban pathway.

  4. PLN pentamers reduce phosphorylation of monomers at baseline and delay monomer phosphorylation upon PKA stimulation leading to increased interaction of PLN monomers with SERCA2a (show ATP2A2 Antibodies).

  5. combined deletion of Phd2 (show EGLN1 Antibodies) and Phd3 (show EGLN3 Antibodies) dramatically decreased expression of phospholamban (PLN), resulted in sustained activation of calcium/calmodulin (show Calm2 Antibodies)-activated kinase II (CaMKII (show CAMK2G Antibodies)), and sensitized mice to chronic beta-adrenergic stress-induced myocardial injury

  6. the N termini of SLN (show SLN Antibodies) and PLB influence their respective unique functions

  7. CaMKII (show CAMK2G Antibodies)-dependent increase in PLN phosphorylation during reperfusion opposes rather than contributes to ischemia/reperfusion damage.

  8. TNAP (show ALPL Antibodies) plays a role in governing the phosphorylation status of phospholamban in the sarcoplasmic reticulum.

  9. SLN (show SLN Antibodies) and PLN are co-expressed in most fibers, which suggests that super-inhibition of SERCAs may be physiologically important in the regulation of intracellular Ca2 (show CA2 Antibodies)+ in human skeletal muscle.

  10. Epac1 (show RAPGEF3 Antibodies) KO exhibited decreased cardiac contractility with reduced phospholamban (PLN) phosphorylation at serine-16, the major PKA-mediated phosphorylation site.

Rabbit Phospholamban (PLN) interaction partners

  1. Acute expression of R9C mutation of phospholamban in cardiomyocytes was positively inotropic/lusitropic.

  2. Ca(2 (show CA2 Antibodies)+) and PLB phosphorylation relieve SERCA (show ATP2A3 Antibodies)-PLB inhibition by distinct mechanisms, but both are achieved primarily by structural changes within the SERCA (show ATP2A3 Antibodies)-PLB complex, not by dissociation of that complex.

  3. Phosphorylated phospholamban stabilizes a unique conformation of SERCA (show ATP2A3 Antibodies) that is characterized by a compact architecture.

  4. Data suggest that phospholamban PLN's conformational equilibrium is central to maintain sarcoplasmic reticulum Ca(2+)-ATPase (show CA-P60A Antibodies) SERCA's apparent Ca(2 (show CA2 Antibodies)+) affinity within a physiological window.

  5. demonstrate that the role of Arg(9) in phospholamban function is multifaceted: it is important for inhibition of SERCA (show ATP2A3 Antibodies), it increases the efficiency of phosphorylation, and it is critical for protein kinase A recognition

  6. The interaction energies between the N-terminal helix of phospholamban and different POPC lipid/cholesterol bilayers quantitatively confirm its stronger interaction with a higher cholesterol-containing membrane.

  7. The lipid bilayer composition influences the regulation of SERCA (show ATP2A3 Antibodies) by PLN.

  8. Phospholamban overexpression in rabbit ventricular myocytes does not alter sarcoplasmic reticulum Ca transport.

Phospholamban (PLN) Antigen Profile

Protein Summary

The protein encoded by this gene is found as a pentamer and is a major substrate for the cAMP-dependent protein kinase in cardiac muscle. The encoded protein is an inhibitor of cardiac muscle sarcoplasmic reticulum Ca(2+)-ATPase in the unphosphorylated state, but inhibition is relieved upon phosphorylation of the protein. The subsequent activation of the Ca(2+) pump leads to enhanced muscle relaxation rates, thereby contributing to the inotropic response elicited in heart by beta-agonists. The encoded protein is a key regulator of cardiac diastolic function. Mutations in this gene are a cause of inherited human dilated cardiomyopathy with refractory congestive heart failure.

Gene names and symbols associated with anti-Phospholamban (PLN) Antibodies

  • phospholamban (LOC100226261) antibody
  • phospholamban (pln) antibody
  • phospholamban (PLN) antibody
  • phospholamban (Pln) antibody
  • CMD1P antibody
  • CMH18 antibody
  • LOC100226261 antibody
  • Plb antibody
  • Plm antibody

Protein level used designations for anti-Phospholamban (PLN) Antibodies

phospholamban , cardiac phospholamban , PLB

GENE ID SPECIES
100226261 Taeniopygia guttata
100379739 Xenopus (Silurana) tropicalis
5350 Homo sapiens
414755 Canis lupus familiaris
397421 Sus scrofa
101102067 Ovis aries
18821 Mus musculus
64672 Rattus norvegicus
100721387 Cavia porcellus
100125240 Bos taurus
100009299 Oryctolagus cuniculus
396378 Gallus gallus
Selected quality suppliers for anti-Phospholamban (PLN) Antibodies
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