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Phospholamban Proteins (PLN)

The protein encoded by PLN is found as a pentamer and is a major substrate for the cAMP-dependent protein kinase in cardiac muscle. Additionally we are shipping Phospholamban Antibodies (124) and Phospholamban Kits (48) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
PLN 5350 P26678
PLN 18821 P61014
Rat PLN PLN 64672 P61016
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Top Phospholamban Proteins at antibodies-online.com

Showing 5 out of 6 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 49 to 54 Days
$4,244.78
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 49 to 54 Days
$6,041.49
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
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HOST_Escherichia coli (E. coli) Human His tag,GST tag 100 μg Log in to see 11 to 13 Days
$792.00
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HOST_Escherichia coli (E. coli) Trypanosoma cruzi His tag   100 μg Log in to see 14 to 16 Days
$317.63
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PLN Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, ,
Mouse (Murine)

More Proteins for Phospholamban (PLN) Interaction Partners

Human Phospholamban (PLN) interaction partners

  1. PLN may be a key molecular player in rigid substrate-induced cellular hypertrophy in eosinophilic esophagitis.

  2. These data suggest that PLN is, at least partially, oligo-ubiquitinated at Lys (show LYZ Proteins)(3) and degraded through Ser (show SIGLEC1 Proteins)(16)-phosphorylation-mediated poly-ubiquitination during heart failure.

  3. hereditary mutants of phospholamban are associated with heart failure [review]

  4. PLN pentamers reduce phosphorylation of monomers at baseline and delay monomer phosphorylation upon PKA stimulation leading to increased interaction of PLN monomers with SERCA2a (show ATP2A2 Proteins).

  5. Phospholamban R14del mutation carriers are at high risk for malignant ventricular arrhythmias and end-stage heart failure, with left ventricular ejection fraction <45% and sustained or nonsustained ventricular tachycardia as independent risk factors.

  6. Although SLN and PLB binding to SERCA (show ATP2A3 Proteins) have different functional outcomes on the coupling efficiency of SERCA (show ATP2A3 Proteins), both proteins decrease the apparent Ca(2 (show CA2 Proteins)+) affinity of the pump, suggesting that SLN and PLB inhibit SERCA (show ATP2A3 Proteins) by using a similar mechanism.

  7. Phospholamban, and its interacting partners, regulates excitation contraction coupling and myocardial contraction. [Review]

  8. PLN mutations rarely cause cardiomyopathy

  9. analysis of how the conformational dynamics of protein kinase A induced by a lethal mutant of phospholamban hinder phosphorylation

  10. Aim of the present study is to determine the exact pattern of fibrosis and fatty replacement in PLN p.Arg14del mutation positive patients.

Pig (Porcine) Phospholamban (PLN) interaction partners

  1. Phosphorylation of PLB induces spatial rearrangements between the N- and P-domain elements of proximal Ca-ATPase.

  2. Molecular dynamics simulations of phospholamban in solution and in membrane bilayer show two main features: the presence of two well-defined helical domains at the N- and C-termini, and large-amplitude rigid-body motions of these domains.

  3. The expression of SLN and PLB mRNA and protein relative to SERCA1 (show ATP2A1 Proteins) or SERCA2 (show ATP2A2 Proteins) was assessed in ventricle, atrium, and skeltal msucle of mouse, rat, rabbit and pig.

Mouse (Murine) Phospholamban (PLN) interaction partners

  1. These data suggest that PLN is, at least partially, oligo-ubiquitinated at Lys (show LYZ Proteins)(3) and degraded through Ser (show SIGLEC1 Proteins)(16)-phosphorylation-mediated poly-ubiquitination during heart failure.

  2. the commercially available overexpressing phospholamban mouse phenotypically resembles human Centronuclear myopathy and could be used as a model to test potential mechanisms and therapeutic strategies.

  3. Cardioprotective effects of H2S are mediated through acGMP/PKG (show PRKG1 Proteins)/phospholamban pathway.

  4. PLN pentamers reduce phosphorylation of monomers at baseline and delay monomer phosphorylation upon PKA stimulation leading to increased interaction of PLN monomers with SERCA2a (show ATP2A2 Proteins).

  5. combined deletion of Phd2 (show EGLN1 Proteins) and Phd3 (show EGLN3 Proteins) dramatically decreased expression of phospholamban (PLN), resulted in sustained activation of calcium/calmodulin (show Calm2 Proteins)-activated kinase II (CaMKII (show CAMK2G Proteins)), and sensitized mice to chronic beta-adrenergic stress-induced myocardial injury

  6. the N termini of SLN and PLB influence their respective unique functions

  7. CaMKII (show CAMK2G Proteins)-dependent increase in PLN phosphorylation during reperfusion opposes rather than contributes to ischemia/reperfusion damage.

  8. TNAP (show ALPL Proteins) plays a role in governing the phosphorylation status of phospholamban in the sarcoplasmic reticulum.

  9. SLN and PLN are co-expressed in most fibers, which suggests that super-inhibition of SERCAs may be physiologically important in the regulation of intracellular Ca2 (show CA2 Proteins)+ in human skeletal muscle.

  10. Epac1 (show RAPGEF3 Proteins) KO exhibited decreased cardiac contractility with reduced phospholamban (PLN) phosphorylation at serine-16, the major PKA-mediated phosphorylation site.

Rabbit Phospholamban (PLN) interaction partners

  1. Acute expression of R9C mutation of phospholamban in cardiomyocytes was positively inotropic/lusitropic.

  2. Ca(2 (show CA2 Proteins)+) and PLB phosphorylation relieve SERCA (show ATP2A3 Proteins)-PLB inhibition by distinct mechanisms, but both are achieved primarily by structural changes within the SERCA (show ATP2A3 Proteins)-PLB complex, not by dissociation of that complex.

  3. Phosphorylated phospholamban stabilizes a unique conformation of SERCA (show ATP2A3 Proteins) that is characterized by a compact architecture.

  4. Data suggest that phospholamban PLN's conformational equilibrium is central to maintain sarcoplasmic reticulum Ca(2+)-ATPase SERCA's apparent Ca(2 (show CA2 Proteins)+) affinity within a physiological window.

  5. demonstrate that the role of Arg(9) in phospholamban function is multifaceted: it is important for inhibition of SERCA (show ATP2A3 Proteins), it increases the efficiency of phosphorylation, and it is critical for protein kinase A recognition

  6. The interaction energies between the N-terminal helix of phospholamban and different POPC lipid/cholesterol bilayers quantitatively confirm its stronger interaction with a higher cholesterol-containing membrane.

  7. The lipid bilayer composition influences the regulation of SERCA (show ATP2A3 Proteins) by PLN.

  8. Phospholamban overexpression in rabbit ventricular myocytes does not alter sarcoplasmic reticulum Ca transport.

Phospholamban (PLN) Protein Profile

Protein Summary

The protein encoded by this gene is found as a pentamer and is a major substrate for the cAMP-dependent protein kinase in cardiac muscle. The encoded protein is an inhibitor of cardiac muscle sarcoplasmic reticulum Ca(2+)-ATPase in the unphosphorylated state, but inhibition is relieved upon phosphorylation of the protein. The subsequent activation of the Ca(2+) pump leads to enhanced muscle relaxation rates, thereby contributing to the inotropic response elicited in heart by beta-agonists. The encoded protein is a key regulator of cardiac diastolic function. Mutations in this gene are a cause of inherited human dilated cardiomyopathy with refractory congestive heart failure.

Gene names and symbols associated with Phospholamban Proteins (PLN)

  • phospholamban (LOC100226261)
  • phospholamban (pln)
  • phospholamban (PLN)
  • phospholamban (Pln)
  • CMD1P protein
  • CMH18 protein
  • LOC100226261 protein
  • Plb protein
  • Plm protein

Protein level used designations for Phospholamban Proteins (PLN)

phospholamban , cardiac phospholamban , PLB

GENE ID SPECIES
100226261 Taeniopygia guttata
100379739 Xenopus (Silurana) tropicalis
5350 Homo sapiens
414755 Canis lupus familiaris
397421 Sus scrofa
101102067 Ovis aries
18821 Mus musculus
64672 Rattus norvegicus
100721387 Cavia porcellus
100125240 Bos taurus
100009299 Oryctolagus cuniculus
396378 Gallus gallus
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