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Phospholipase A2 Receptor 1 Proteins (PLA2R1)

Receptor for secretory phospholipase A2 (sPLA2). Additionally we are shipping PLA2R1 Antibodies (10) and PLA2R1 Kits (6) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
Mouse PLA2R1 PLA2R1 18779 Q62028
Rat PLA2R1 PLA2R1 295631  
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Top PLA2R1 Proteins at

Showing 2 out of 2 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag,T7 tag 100 μg Log in to see 11 to 13 Days
HOST_Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 9 to 19 Days

PLA2R1 Proteins by Origin and Source

Origin Expressed in Conjugate

More Proteins for Phospholipase A2 Receptor 1 (PLA2R1) Interaction Partners

Mouse (Murine) Phospholipase A2 Receptor 1 (PLA2R1) interaction partners

  1. Study showed that CTLD1-2 as well as the FNII domain of PLA2R were responsible for binding to collagen I and collagen-dependent migration in both mouse and human PLA2R.

  2. PLA2R might play a pathogenic role in myocardial infarction of PLA2R-deficient mice, through impaired healing of the infarcted region.

  3. PLA2R deficiency increased sPLA2 (show PLA2G2A Proteins)-IB and -X levels in the lung through their impaired clearance from the lung, leading to exaggeration of lung inflammation induced by OVA treatment in a murine model.

PLA2R1 Protein Profile

Protein Summary

Receptor for secretory phospholipase A2 (sPLA2). Acts as a receptor for phosholipases sPLA2-IB/PLA2G1B, sPLA2-X/PLA2G10 and, with lower affinity, sPLA2-IIA/PLA2G2A. Also able to bind to snake PA2-like toxins. Although its precise function remains unclear, binding of sPLA2 to its receptor participates in both positive and negative regulation of sPLA2 functions as well as clearance of sPLA2. Binding of sPLA2-IB/PLA2G1B induces various effects depending on the cell type, such as activation of the mitogen-activated protein kinase (MAPK) cascade to induce cell proliferation, the production of lipid mediators, selective release of arachidonic acid in bone marrow-derived mast cells. In neutrophils, binding of sPLA2-IB/PLA2G1B can activate p38 MAPK to stimulate elastase release and cell adhesion. May be involved in responses in proinflammatory cytokine productions during endotoxic shock. Also has endocytic properties and rapidly internalizes sPLA2 ligands, which is particularly important for the clearance of extracellular sPLA2s to protect their potent enzymatic activities. The soluble secretory phospholipase A2 receptor form is circulating and acts as a negative regulator of sPLA2 functions by blocking the biological functions of sPLA2-IB/PLA2G1B and sPLA2-X/PLA2G10.

Gene names and symbols associated with PLA2R1

  • phospholipase A2 receptor 1, 180kDa (PLA2R1)
  • phospholipase A2 receptor 1 (Pla2r1)
  • Mrc2 protein
  • Pla2-r protein
  • Pla2g1br protein
  • Pla2r protein

Protein level used designations for PLA2R1

secretory phospholipase A2 receptor , yolk sac IgY receptor , phospholipase A2 receptor 1, 180kDa , secretory phospholipase A2 receptor-like , 180 kDa secretory phospholipase A2 receptor , M-type receptor , PLA2-I receptor , phospholipase A2, group IB, pancreas, receptor , mannose receptor, C type 2

404304 Gallus gallus
488367 Canis lupus familiaris
739140 Pan troglodytes
100022002 Monodelphis domestica
100081912 Ornithorhynchus anatinus
100401998 Callithrix jacchus
100548495 Meleagris gallopavo
100600379 Nomascus leucogenys
18779 Mus musculus
295631 Rattus norvegicus
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