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Phospholipase C zeta 1 Proteins (PLCz1)

The protein encoded by PLCz1 is a member of the phosphoinositide-specific phospholipase C family. Additionally we are shipping Phospholipase C zeta 1 Antibodies (25) and Phospholipase C zeta 1 Kits (13) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
PLCz1 114875 Q8K4D7
PLCz1 497197 Q5FX52
PLCz1 89869 Q86YW0
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Top Phospholipase C zeta 1 Proteins at antibodies-online.com

Showing 4 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His-SUMO Tag 50 μg Log in to see 21 to 26 Days
$341.00
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$3,868.33
Details

PLCz1 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Rat (Rattus)

Human
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More Proteins for Phospholipase C zeta 1 (PLCz1) Interaction Partners

Pig (Porcine) Phospholipase C zeta 1 (PLCz1) interaction partners

  1. Results suggest a mechanism by which phospholipase C zeta originates from an oocyte-penetrating assembly--the sperm perinuclear matrix--to induce mammalian oocyte activation at fertilization.

Mouse (Murine) Phospholipase C zeta 1 (PLCz1) interaction partners

  1. Human PLCzeta exhibits superior fertilization potency over mouse PLCzeta in triggering the Ca(2 (show CA2 Proteins)+) oscillations required for mammalian oocyte activation.

  2. these results suggest that both PLCzeta- and sperm-mediated Ca2 (show CA2 Proteins)+ release preferentially use an intracellular membranous source of PI(4,5)P2, in contrast to PLCdelta1, which targets PI(4,5)P2 in the plasma membrane.

  3. Data suggest that positively charged residues within the XY linker play an important role in the PLCzeta interaction with PtdIns(4,5)P(2), a crucial step in generating the Ca(2 (show CA2 Proteins)+) activation signal that is essential for fertilization in mammals.

  4. Murine PLCZ1 and bovine PLCZ1 possess species-specific differences in activity and suggest potential differences in the mode of action of the protein between the two species.

  5. purified PLCzeta protein induces Ca(2 (show CA2 Proteins)+) oscillations, indicating that PLCzeta is a proper candidate of the mammalian egg-activating sperm factor

  6. Cell cycle-dependent Ca2 (show CA2 Proteins)+ oscillations are regulated by nuclear targeting of PlCzeta.

  7. Results suggest a mechanism by which phospholipase C zeta originates from an oocyte-penetrating assembly--the sperm perinuclear matrix--to induce mammalian oocyte activation at fertilization.

  8. PLCzeta is the physiological trigger of Ca(2 (show CA2 Proteins)+) oscillations required for activation of development

  9. interaction of PI(3 (show PI3 Proteins))P and PI(5)P could play a role for negative regulation of PLCzeta

  10. PLCzeta exhibited alternative cytoplasm/nucleus localization during development

Human Phospholipase C zeta 1 (PLCz1) interaction partners

  1. Human PLCzeta elicited the characteristic Ca(2 (show CA2 Proteins)+) oscillations present at mammalian fertilization, which produced oocyte activation and embryo development.

  2. Study further supports the fundamental role of PLCzeta in the oocyte activation process.

  3. Phospholipase C-zeta deficiency is associated with repetitive oocyte fertilization failure during ovarian stimulation for in vitro fertilization.

  4. I discuss the recent advances in our knowledge of the intriguing biochemical and physiological properties of sperm PLCz and postulate potential roles for PLCz in terms of clinical diagnosis and therapy for certain forms of male infertility

  5. Data suggest that PAWP (WW domain-binding protein 2-like (show WBP2NL Proteins)) from sperm (rather than PLCZ [phospholipase C zeta] from sperm) acts as the 'sperm factor' within the egg at fertilization and is involved in 'egg activation' and embryogenesis. [REVIEW]

  6. in patients with normal SA parameters but with repeated low fertilization or outright failed fertilization results after ICSI, abnormal PLCZ1 function should be considered as the underlying mechanism responsible for the failure of fertilization

  7. Human PLCzeta exhibits superior fertilization potency over mouse PLCzeta in triggering the Ca(2 (show CA2 Proteins)+) oscillations required for mammalian oocyte activation.

  8. Male infertility is associated with the aberrant expression, localisation, structure and function of PLCzeta in human sperm. [review]

  9. PLCzeta may be a significant factor in human fertility with potential therapeutic capacity. [Review]

  10. investigation of expression level and localization pattern of PLCZ1 in sperm from three infertile patients with globozoospermia (i.e., patients who exhibited abnormal sperm with round heads) [CASE REPORT]

Cow (Bovine) Phospholipase C zeta 1 (PLCz1) interaction partners

  1. A novel splice variant of Phospholipase C zeta 1 in the testis tissues of adult and fetal Chinese Holstein bulls was characterized.

  2. Murine PLCZ1 and bovine PLCZ1 possess species-specific differences in activity and suggest potential differences in the mode of action of the protein between the two species

Phospholipase C zeta 1 (PLCz1) Protein Profile

Protein Summary

The protein encoded by this gene is a member of the phosphoinositide-specific phospholipase C family. Members in this family, classified into six isotypes that are tissue- and organ-specific, hydrolyze phosphatidylinositol 4,5-bisphosphate just before the phosphate group to yield diacylglycerol and inositol 1,4,5-trisphosphate. This protein localizes to the acrosome in spermatozoa and elicits Ca(2+) oscillations and egg activation during fertilization that leads to early embryonic development. Alternative splicing results in multiple transcript variants.

Gene names and symbols associated with Phospholipase C zeta 1 Proteins (PLCz1)

  • phospholipase c-zeta (PLCZ)
  • phospholipase C, zeta 1 (Plcz1)
  • phospholipase C, zeta 1 (PLCZ1)
  • 1700041H07Rik protein
  • NYD-SP27 protein
  • PLC-zeta-1 protein
  • PLCZ protein
  • PLCZ1 protein
  • PLCzeta protein

Protein level used designations for Phospholipase C zeta 1 Proteins (PLCz1)

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 , 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase zeta-1 , Phospholipase C-zeta-1 , phosphoinositide phospholipase C-zeta-1 , PLC-zeta-1 , phospholipase C zeta , phospholipase C-zeta-1 , PI-phospholipase C zeta 1 , testis-development related NYD-SP27

GENE ID SPECIES
397632 Sus scrofa
114875 Mus musculus
497197 Rattus norvegicus
89869 Homo sapiens
486657 Canis lupus familiaris
497026 Bos taurus
418182 Gallus gallus
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