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The protein encoded by PLCz1 is a member of the phosphoinositide-specific phospholipase C family. Additionally we are shipping Phospholipase C zeta 1 Antibodies (25) and Phospholipase C zeta 1 Kits (4) and many more products for this protein.
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Results suggest a mechanism by which phospholipase C zeta originates from an oocyte-penetrating assembly--the sperm perinuclear matrix--to induce mammalian oocyte activation at fertilization.
Human PLCzeta exhibits superior fertilization potency over mouse PLCzeta in triggering the Ca(2 (show CA2 Proteins)+) oscillations required for mammalian oocyte activation.
these results suggest that both PLCzeta- and sperm-mediated Ca2 (show CA2 Proteins)+ release preferentially use an intracellular membranous source of PI(4,5)P2, in contrast to PLCdelta1, which targets PI(4,5)P2 in the plasma membrane.
Data suggest that positively charged residues within the XY linker play an important role in the PLCzeta interaction with PtdIns(4,5)P(2), a crucial step in generating the Ca(2 (show CA2 Proteins)+) activation signal that is essential for fertilization in mammals.
Murine PLCZ1 and bovine PLCZ1 possess species-specific differences in activity and suggest potential differences in the mode of action of the protein between the two species.
purified PLCzeta protein induces Ca(2 (show CA2 Proteins)+) oscillations, indicating that PLCzeta is a proper candidate of the mammalian egg-activating sperm factor
Cell cycle-dependent Ca2 (show CA2 Proteins)+ oscillations are regulated by nuclear targeting of PlCzeta.
PLCzeta is the physiological trigger of Ca(2 (show CA2 Proteins)+) oscillations required for activation of development
interaction of PI(3 (show PI3 Proteins))P and PI(5)P could play a role for negative regulation of PLCzeta
PLCzeta exhibited alternative cytoplasm/nucleus localization during development
In male infertility, the absence of PLCZ1 alone is sufficient to prevent oocyte activation irrespective of the presence of PAWP (show WBP2NL Proteins).
Human PLCzeta elicited the characteristic Ca(2 (show CA2 Proteins)+) oscillations present at mammalian fertilization, which produced oocyte activation and embryo development.
Study further supports the fundamental role of PLCzeta in the oocyte activation process.
Phospholipase C-zeta deficiency is associated with repetitive oocyte fertilization failure during ovarian stimulation for in vitro fertilization.
I discuss the recent advances in our knowledge of the intriguing biochemical and physiological properties of sperm PLCz and postulate potential roles for PLCz in terms of clinical diagnosis and therapy for certain forms of male infertility
Data suggest that PAWP (WW domain-binding protein 2-like (show WBP2NL Proteins)) from sperm (rather than PLCZ [phospholipase C zeta] from sperm) acts as the 'sperm factor' within the egg at fertilization and is involved in 'egg activation' and embryogenesis. [REVIEW]
in patients with normal SA parameters but with repeated low fertilization or outright failed fertilization results after ICSI, abnormal PLCZ1 function should be considered as the underlying mechanism responsible for the failure of fertilization
Male infertility is associated with the aberrant expression, localisation, structure and function of PLCzeta in human sperm. [review]
PLCzeta may be a significant factor in human fertility with potential therapeutic capacity. [Review]
A novel splice variant of Phospholipase C zeta 1 in the testis tissues of adult and fetal Chinese Holstein bulls was characterized.
Murine PLCZ1 and bovine PLCZ1 possess species-specific differences in activity and suggest potential differences in the mode of action of the protein between the two species
The protein encoded by this gene is a member of the phosphoinositide-specific phospholipase C family. Members in this family, classified into six isotypes that are tissue- and organ-specific, hydrolyze phosphatidylinositol 4,5-bisphosphate just before the phosphate group to yield diacylglycerol and inositol 1,4,5-trisphosphate. This protein localizes to the acrosome in spermatozoa and elicits Ca(2+) oscillations and egg activation during fertilization that leads to early embryonic development. Alternative splicing results in multiple transcript variants.
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1
, 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase zeta-1
, Phospholipase C-zeta-1
, phosphoinositide phospholipase C-zeta-1
, phospholipase C zeta
, phospholipase C-zeta-1
, PI-phospholipase C zeta 1
, testis-development related NYD-SP27