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The protein encoded by PLTP is one of at least two lipid transfer proteins found in human plasma. Additionally we are shipping PLTP Antibodies (87) and PLTP Kits (30) and many more products for this protein.
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Human PLTP Protein expressed in Human Cells - ABIN2004045
Valenta, Bulgrien, Bonnet, Curtiss: Macrophage PLTP is atheroprotective in LDLr-deficient mice with systemic PLTP deficiency. in Journal of lipid research 2007
Human PLTP Protein expressed in Wheat germ - ABIN1315481
Henderson, Leon, Wasan: Differences in human phospholipid transfer protein activity following incubation of Fungizone compared to lipid-based Amphotericin-B formulations in normolipidemic and hyperlipidemic plasma. in Drug development and industrial pharmacy 2009
identification and characterization of CaM (show CALM Proteins)-binding domain of non-specific lipid transfer proteins
association of PON-1 (show PON1 Proteins) activity with PLTP activity was lost in analysis which included large HDL (show HSD11B1 Proteins) particles
a novel association between PLTPa and PON1 (show PON1 Proteins) activity
The domain of apolipoprotein E4 required for PLTP activation resides within its amino-terminal 1-185 region.
Elevated baseline plasma levels of PLTP are associated with an increased risk of long-term all-cause mortality in patients with diabetes and known or suspected coronary disease.
This review summarizes the recent progresses made in the PLTP research field and focuses on the complexity of the implication of PLTP in obesity, insulin (show INS Proteins) resistance and type 2 diabetes mellitus. [review]
Elevated plasma PLTP activity may predict an increased risk of T2DM in men
High systemic PLTP expression does not contribute significantly to a renal phenotype despite being implicated in systemic atherosclerosis in ApoE (show APOE Proteins) deficient mice.
proteolytic cleavage of PLTP by cathepsin G (show CTSG Proteins) may enhance the injurious inflammatory responses that occur in COPD (show ARCN1 Proteins)
PLTP is actively involved in lipid transfer, cholesterol efflux, HDL (show HSD11B1 Proteins) genesis, and remodeling at the blood-brain barrier.
Lower plasma CETP (show CETP Proteins) or higher PLTP activity was each associated with a significantly increased risk of cardiovascular disease.
these findings elucidated that PLTP repressed LPS (show TLR4 Proteins) induced inflammation due to extracellular LPS (show TLR4 Proteins) binding capability, and the protective effects were not related to HDL (show HSD11B1 Proteins) pool size in mice.
Data presented a novel model to link phospholipid metabolism to APP (show APP Proteins) processing and also suggested that PLTP played an important role in Abeta (show APP Proteins) metabolism and would be useful to further elucidate functions of PLTP in Alzheimer's disease susceptibility.
In hepatocytes, initial recruitment of phospholipid (PL) by apoB (show APOB Proteins):1000 leading to the formation of the PL-rich apoB (show APOB Proteins)-containing initiation complex is mediated to a large extent by PLTP.
PLTP plays an important role in modulating the stability of atherosclerotic plaques. The receptor-interacting protein 3 (show RIPK3 Proteins)- reactive oxygen species signal pathway could be involved in this PLTP-mediated process.
Adipocyte PLTP plays a small but significant role in plasma PLTP activity and promotes cholesterol efflux from adipose tissues.
PLTP exerts significant effects on apoA-I (show APOA1 Proteins) lipidation and nascent HDL (show HSD11B1 Proteins) biogenesis in hepatocytes by promoting ATP-binding cassette transporter A1 (show ABCA1 Proteins)-mediated lipid efflux and the remodeling of nascent HDL (show HSD11B1 Proteins) particles.
Plasma Sphingosine-1-phosphate contents were decreased by 60.1 % in PLTP knockout mice (PLTP-/-, N = 5) compared with their wild type littermates (WT, N = 5) (151.70 +/- 38.59 vs. 379.32 +/- 59.90 nmol/l, P<0.01).
Therefore we concluded that PLTP deficiency impaired cognition and aggravated AD by enhancing the generation of Abeta (show APP Proteins) in the cortex of old mice.
Cerebrovascular oxidative stress increased in PLTP deficient mice, including increased levels of reactive oxygen species (ROS) and lipid peroxidation marker 4-hydroxy-2-nonenal (HNE) and reduced superoxide dismutase (SOD) activity.
Results suggest that phospholipid transfer protein (PLTP) polymorphisms might be an important genetic influence on economic traits in Hanwoo (Korean cattle).
The protein encoded by this gene is one of at least two lipid transfer proteins found in human plasma. The encoded protein transfers phospholipids from triglyceride-rich lipoproteins to high density lipoprotein (HDL). In addition to regulating the size of HDL particles, this protein may be involved in cholesterol metabolism. At least two transcript variants encoding different isoforms have been found for this gene.
phospholipid transfer protein
, BPI fold containing family E
, lipid transfer protein II
, plasma phospholipid transfer protein
, PLTP-like protein