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Phosphomevalonate Kinase Proteins (PMVK)

PMVK encodes a peroxisomal enzyme that catalyzes the conversion of mevalonate 5-phosphate into mevalonate 5-diphosphate, the fifth reaction of the cholesterol biosynthetic pathway. Additionally we are shipping Phosphomevalonate Kinase Antibodies (56) and Phosphomevalonate Kinase Kits (4) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
PMVK 10654 Q15126
PMVK 68603 Q9D1G2
Rat PMVK PMVK 310645  
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Top Phosphomevalonate Kinase Proteins at antibodies-online.com

Showing 10 out of 16 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag 50 μg Log in to see 16 Days
$272.80
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 7 to 8 Days
$319.00
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Wild boar His tag   1 mg Log in to see 56 to 66 Days
$2,267.83
Details
Yeast Cow His tag   1 mg Log in to see 56 to 66 Days
$2,460.33
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 3 to 4 Days
$364.64
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details
Human Un-conjugated   5 μg Log in to see 6 Days
$168.54
Details

PMVK Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
,
Mouse (Murine)

Top referenced Phosphomevalonate Kinase Proteins

  1. Human PMVK Protein expressed in Escherichia coli (E. coli) - ABIN3216417 : Danielsen, Sylvestersen, Bekker-Jensen, Szklarczyk, Poulsen, Horn, Jensen, Mailand, Nielsen: Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. in Molecular & cellular proteomics : MCP 2011 (PubMed)

  2. Human PMVK Protein expressed in Escherichia coli (E. coli) - ABIN667225 : Hogenboom, Tuyp, Espeel, Koster, Wanders, Waterham: Phosphomevalonate kinase is a cytosolic protein in humans. in Journal of lipid research 2004 (PubMed)

More Proteins for Phosphomevalonate Kinase (PMVK) Interaction Partners

Human Phosphomevalonate Kinase (PMVK) interaction partners

  1. found an exclusive cytosolic localization of both endogenously expressed PMVK(in human fibroblasts, human liver, and HEK293 cells) and overexpressed PMVK. No indication of a peroxisomal localization was obtained.

  2. Functional evaluation of conserved basic residues in PMVK is reported.

  3. This is the first report of hPMK crystal structure that suggests a potential substrate binding site and a possible enzyme catalytic mechanism.

  4. Binding of mevalonate 5-phosphate causes the phosphomevalonate kinase structure to compress (tau(c) = 13.5 nsec), whereas subsequent binding of Mg-ADP opens the structure up (tau(c) = 15.6 nsec).

Phosphomevalonate Kinase (PMVK) Protein Profile

Protein Summary

This gene encodes a peroxisomal enzyme that catalyzes the conversion of mevalonate 5-phosphate into mevalonate 5-diphosphate, the fifth reaction of the cholesterol biosynthetic pathway. Studies in rat show that the message level and the enzyme activity of this protein is regulated by sterol, and that this regulation is coordinated with 3-hydroxy-3-methylglutaryl coenzyme A reductase, the rate-limiting enzyme of cholesterol biosynthesis.

Gene names and symbols associated with PMVK

  • phosphomevalonate kinase (PMVK)
  • phosphomevalonate kinase (Mpk)
  • GHMP kinase family protein (AT1G31910)
  • phosphomevalonate kinase (CpipJ_CPIJ015413)
  • phosphomevalonate kinase (Bm1_05275)
  • phosphomevalonate kinase (pmvk)
  • phosphomevalonate kinase (LOAG_11811)
  • phosphomevalonate kinase (Tsp_06629)
  • phosphomevalonate kinase (LOC100282968)
  • phosphomevalonate kinase (Pmvk)
  • 1110011E12Rik protein
  • 2900002L22Rik protein
  • AV001327 protein
  • F5M6.9 protein
  • F5M6_9 protein
  • HUMPMKI protein
  • MPK_Bm protein
  • PMK protein
  • PMKA protein
  • PMKASE protein
  • zgc:162701 protein

Protein level used designations for PMVK

phosphomevalonate kinase , hPMK , PMKase

GENE ID SPECIES
457350 Pan troglodytes
612251 Canis lupus familiaris
692835 Bombyx mori
717014 Macaca mulatta
840081 Arabidopsis thaliana
6049213 Culex quinquefasciatus
6095986 Brugia malayi
8570979 Lactobacillus johnsonii FI9785
9949270 Loa loa
10909538 Trichinella spiralis
100003383 Danio rerio
100282968 Zea mays
10654 Homo sapiens
68603 Mus musculus
310645 Rattus norvegicus
100152301 Sus scrofa
513533 Bos taurus
Selected quality suppliers for Phosphomevalonate Kinase Proteins (PMVK)
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