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The protein encoded by PPAT is a member of the purine/pyrimidine phosphoribosyltransferase family. Additionally we are shipping PPAT Proteins (5) and PPAT Kits (3) and many more products for this protein.
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Human Polyclonal PPAT Primary Antibody for EIA, WB - ABIN357903
Bera, Chen, Smith, Zalkin: Interdomain signaling in glutamine phosphoribosylpyrophosphate amidotransferase. in The Journal of biological chemistry 2000
Show all 2 references for ABIN357903
DREF (show ZBED1 Antibodies) binds directly upstream of Prat and the DRE (show SUFUH Antibodies) sites associated with its activity are necessary for Prat expression
Data show the presence of apoptosis at the cellular level in both ade2 (show PAICS Antibodies) and Prat mutants, and the upregulated gene HtrA2 (show HTRA2 Antibodies), which encodes an apoptosis effector and is thus a candidate for initiating apoptosis in response to purine depletion.
whereas Mod (show MOD(MDG4) Antibodies)(Prat:bw)3-5 suppresses Prat in all stages and tissues examined for both sexes.
Evidence suggests that Prat originated by gene duplication by retrotransposition of Prat2.
Regulation of expression of prat in the adult eye was studied.
Use of Prat and Prat2 double RNA interference causes more severe pupal lethal phenotypes and suggests that Prat and Prat2 have partially additive functions during Drosophila metamorphosis.
Data show that the requirement for both Prat and Prat2 in Drosophila is not simply due to differences in protein function. Both genes have developed nonoverlapping patterns of expression, which correlate with their respective loss-of-function phenotypes.
purine biosynthetic pathway enzymes PPAT and PAICS, as well as pyruvate kinase activity are increased in lung cancer
The protein encoded by this gene is a member of the purine/pyrimidine phosphoribosyltransferase family. It is a regulatory allosteric enzyme that catalyzes the first step of de novo purine nucleotide biosythetic pathway. This gene and PAICS/AIRC gene, a bifunctional enzyme catalyzing steps six and seven of this pathway, are located in close proximity on chromosome 4, and divergently transcribed from an intergenic region.
, transcript D
, phosphoribosyl pyrophosphate amidotransferase
, glutamine PRPP amidotransferase
, glutamine phosphoribosylpyrophosphatate amidotransferase
, glutamine phosphoribosylpyrophosphate amidotransferase