Use your antibodies-online credentials, if available.
No Products on your Comparison List.
Your basket is empty.
Find out more
The protein encoded by GART is a trifunctional polypeptide.
The minor A allele of rs7279549 of GART is a functional risk factor for congenital heart disease in Shandong population.
most significant association was detected for GART rs8971. Compared with individuals with the TT genotype, the age- and sex-adjusted odds ratio (OR) for developing HCC (show FAM126A Proteins) was 1.44 (95% confidence interval (CI): 1.03-2.02) among those with the CC genotype
The current results showed that GART expression was associated with glioma grade and that high GART protein expression might be related to poor outcome.
our clinical and in vitro data indicate that GART expression may be one of the causative factors for a poor prognosis in hepatocellular carcinoma.
High-resolution structural data for GART (transformylase domain; purN) reveal new binding mode for lipophilic diastereoisomer inhibitors of GART, folate analogs with anti-leukemic activity.
Using the SNaPshot assay, evidence presented for allelic nondisjunction at rs363506 in the GRIK1 (show GRIK1 Proteins) gene and rs2834235 and rs7283354 in the GARS-AIRS-GART gene in Down syndrome in India.
GART has an approximate seesaw geometry where terminal enzyme units display high mobility owing to flexible linker segments.
The pH-dependent activity in human GART is due to its inability to bind the substrate, beta-glycinamide ribonucleotide, at low pH on the basis of structural studies at high and low pH.
Substrate/cosubstrate flexibility and cosubstrate preactivation are critical for the catalytic mechanism of human GART
The Expression of baseline GARTF tended to be higher in responders but this association was not significant.
Three novel mutations with very damaging effect on the protein structure, according to SIFT and Polyphen-2, were detected in GART, SHBG and SLC37A2 genes.
The protein encoded by this gene is a trifunctional polypeptide. It has phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase activity which is required for de novo purine biosynthesis. This enzyme is highly conserved in vertebrates. Alternative splicing of this gene results in two transcript variants encoding different isoforms.
phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase
, phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase, isoform 1
, trifunctional purine biosynthetic protein adenosine-3-like
, trifunctional purine biosynthetic protein adenosine-3
, glycinamide ribonucleotide synthetase
, phosphoribosylglycinamide synthetase
, aminoimidazole ribonucleotide synthetase