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Piezo-Type Mechanosensitive Ion Channel Component 1 Proteins (PIEZO1)

Piezos are large transmembrane proteins conserved among various species, all having between 24 and 36 predicted transmembrane domains. Additionally we are shipping PIEZO1 Antibodies (42) and PIEZO1 Kits (5) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
PIEZO1 9780 Q92508
PIEZO1 234839  
Rat PIEZO1 PIEZO1 361430 Q0KL00
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Top PIEZO1 Proteins at antibodies-online.com

Showing 4 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   5 applications Log in to see 1 to 2 Days
$312.71
Details

PIEZO1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
,
Mouse (Murine)

More Proteins for Piezo-Type Mechanosensitive Ion Channel Component 1 (PIEZO1) Interaction Partners

Human Piezo-Type Mechanosensitive Ion Channel Component 1 (PIEZO1) interaction partners

  1. Piezo1 responds to lateral membrane tension with exquisite sensitivity as compared to other mechanically activated channels and that resting tension can drive channel inactivation, thereby tuning overall mechanical sensitivity of Piezo1.

  2. Mutations in PIEZO1 is associated with persistent lymphoedema caused by congenital lymphatic dysplasia.

  3. Homozygous and compound heterozygous mutations in PIEZO1, result in an autosomal recessive form of generalized lymphatic dysplasia with a high incidence of non-immune hydrops fetalis and childhood onset of facial and four limb lymphoedema.

  4. Mechanically activated Piezo1 plays an essential role in red blood cell volume homeostasis.

  5. Piezo1 is amenable to chemical activation and thus there is a possibility that endogenous Piezo1 agonists might exist.

  6. PIEZO1 is permeable to monovalent ions (K+, Na+, Cs+, Li+) and most divalent ions (Ba2+, Ca2 (show CA2 Proteins)+ and Mg2 (show MUC7 Proteins)+), but not to Mn2+.

  7. a possible role of Piezo1 in invasion and metastatic propagation.

  8. Piezo1 channels are likely to function in normal RBCs (show SSU1 Proteins) and suggest a previously unidentified mechanotransductive pathway in ATP release.

  9. study reports two unrelated families with hereditary xerocytosis where probands presented fetal hydrops for which the same heterozygous mutation in PIEZO1 was identified

  10. PIEZO1 stretch sensitivity is modulated by polycystin-2 (show PKD2 Proteins).

Mouse (Murine) Piezo-Type Mechanosensitive Ion Channel Component 1 (PIEZO1) interaction partners

  1. Our results suggest that Piezo1 is unlikely to be a component of the mechanoelectrical transducer channel complex in mammalian cochlear outer hair cells

  2. Smooth muscle Piezo1 is required for stretch-activated cationic channel activity. PIezo1 is involved in the remodeling of small arteries.

  3. This study demonstrated that Piezo1 proteins consist of distinct responsible for ion conduction, mechanical force sensing, and transduction to coordinately fulfill their function as sophisticated MS channels.

  4. Astrocytes in optic nerve head express multiple mechanosensitive channels, in particular Piezo1 and 2. The expression of putative mechanosensitive channels in these cells may contribute to their responsiveness to traumatic or glaucomatous injury.

  5. cryo-electron microscopy structure of the full-length (2,547 amino acids) mouse Piezo1 (Piezo1) at a resolution of 4.8 A

  6. Piezo1 channels as sensors of blood flow was shown by Piezo1 dependence of shear-stress-evoked ionic current and calcium influx in endothelial cells and the ability of exogenous Piezo1 to confer sensitivity to shear stress on otherwise resistant cells

  7. Piezo1 is activated by shear stress, the major type of mechanical force experienced by endothelial cells in response to blood flow.

  8. overexpression of Piezo1 or Piezo2 induced 2 kinetically distinct mechanically activated (MA) currents; Piezos are expressed in several tissues; propose that Piezos are components of MA cation channels

PIEZO1 Protein Profile

Protein Summary

Piezos are large transmembrane proteins conserved among various species, all having between 24 and 36 predicted transmembrane domains. 'Piezo' comes from the Greek 'piesi,' meaning 'pressure.' The FAM38A gene encodes PIEZO1, a protein that induces mechanically activated (MA) currents in various cell types (Coste et al., 2010

Gene names and symbols associated with PIEZO1

  • piezo-type mechanosensitive ion channel component 1 (PIEZO1)
  • piezo-type mechanosensitive ion channel component 1 (Piezo1)
  • 9630020g22 protein
  • DHS protein
  • Fam38a protein
  • Mib protein
  • mKIAA0233 protein

Protein level used designations for PIEZO1

family with sequence similarity 38, member A , membrane protein induced by beta-amyloid treatment , protein PIEZO1

GENE ID SPECIES
9780 Homo sapiens
234839 Mus musculus
361430 Rattus norvegicus
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