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Piezos are large transmembrane proteins conserved among various species, all having between 24 and 36 predicted transmembrane domains. Additionally we are shipping PIEZO1 Kits (6) and PIEZO1 Proteins (3) and many more products for this protein.
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Human Polyclonal PIEZO1 Primary Antibody for ICC, IF - ABIN4345461
Lee, Guevarra, Nguyen, Chua, Wang, Jacobs: The primary cilium functions as a mechanical and calcium signaling nexus. in Cilia 2015
Human Polyclonal PIEZO1 Primary Antibody for ICC, IF - ABIN4345459
Gudipaty, Lindblom, Loftus, Redd, Edes, Davey, Krishnegowda, Rosenblatt: Mechanical stretch triggers rapid epithelial cell division through Piezo1. in Nature 2017
correlation between HPCHA and PIEZO1-gene mutated findings raise an important question as to whether any of the high phosphatidylcholine (show SGMS2 Antibodies) hemolytic anemia cases previously diagnosed in Japan may have in fact been the form of hemolytic anemia known as hereditary xerocytosis or dehydrated hereditary stomatocytosis with PIEZO1 gene mutation
Piezo1 responds to lateral membrane tension with exquisite sensitivity as compared to other mechanically activated channels and that resting tension can drive channel inactivation, thereby tuning overall mechanical sensitivity of Piezo1.
Mutations in PIEZO1 is associated with persistent lymphoedema caused by congenital lymphatic dysplasia.
Homozygous and compound heterozygous mutations in PIEZO1, result in an autosomal recessive form of generalized lymphatic dysplasia with a high incidence of non-immune hydrops fetalis and childhood onset of facial and four limb lymphoedema.
Mechanically activated Piezo1 plays an essential role in red blood cell volume homeostasis.
Piezo1 is amenable to chemical activation and thus there is a possibility that endogenous Piezo1 agonists might exist.
PIEZO1 is permeable to monovalent ions (K+, Na+, Cs+, Li+) and most divalent ions (Ba2+, Ca2 (show CA2 Antibodies)+ and Mg2 (show MUC7 Antibodies)+), but not to Mn2+.
a possible role of Piezo1 in invasion and metastatic propagation.
Piezo1 channels are likely to function in normal RBCs and suggest a previously unidentified mechanotransductive pathway in ATP release.
study reports two unrelated families with hereditary xerocytosis where probands presented fetal hydrops for which the same heterozygous mutation in PIEZO1 was identified
Our results suggest that Piezo1 is unlikely to be a component of the mechanoelectrical transducer channel complex in mammalian cochlear outer hair cells
Smooth muscle Piezo1 is required for stretch-activated cationic channel activity. PIezo1 is involved in the remodeling of small arteries.
This study demonstrated that Piezo1 proteins consist of distinct responsible for ion conduction, mechanical force sensing, and transduction to coordinately fulfill their function as sophisticated MS channels.
Astrocytes in optic nerve head express multiple mechanosensitive channels, in particular Piezo1 and 2. The expression of putative mechanosensitive channels in these cells may contribute to their responsiveness to traumatic or glaucomatous injury.
cryo-electron microscopy structure of the full-length (2,547 amino acids) mouse Piezo1 (Piezo1) at a resolution of 4.8 A
Piezo1 channels as sensors of blood flow was shown by Piezo1 dependence of shear-stress-evoked ionic current and calcium influx in endothelial cells and the ability of exogenous Piezo1 to confer sensitivity to shear stress on otherwise resistant cells
Piezo1 is activated by shear stress, the major type of mechanical force experienced by endothelial cells in response to blood flow.
overexpression of Piezo1 or Piezo2 (show FAM38B Antibodies) induced 2 kinetically distinct mechanically activated (MA) currents; Piezos are expressed in several tissues; propose that Piezos are components of MA cation channels
Piezos are large transmembrane proteins conserved among various species, all having between 24 and 36 predicted transmembrane domains. 'Piezo' comes from the Greek 'piesi,' meaning 'pressure.' The FAM38A gene encodes PIEZO1, a protein that induces mechanically activated (MA) currents in various cell types (Coste et al., 2010
family with sequence similarity 38, member A
, membrane protein induced by beta-amyloid treatment
, protein PIEZO1