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anti-Pigeon Homolog (Drosophila) (PION) Antibodies

Accumulation of neurotoxic amyloid-beta is a major hallmark of Alzheimer disease (AD; MIM 104300). Additionally we are shipping Pigeon Homolog (Drosophila) Kits (8) and Pigeon Homolog (Drosophila) Proteins (6) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
PION 54103 A4D1B5
PION 212167 Q3TCV3
PION 311984  
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Top anti-Pigeon Homolog (Drosophila) Antibodies at antibodies-online.com

Showing 10 out of 44 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated EIA, IHC (p), WB Immunohistochemistry analysis in formalin fixed and paraffin embedded human skeletal muscle reacted withPION / GSAP (C-term) Antibody (C-term) followed by peroxidase conjugation of the secondary antibody and DAB staining. Western blot analysis of PION / GSAP (C-term) Antibody (C-term) in NCI-H292 cell line lysates (35ug/lane). This demonstrates the PION antibody detected the PION protein (arrow). 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated WB 100 μg Log in to see 2 to 3 Days
$315.00
Details
Human Rabbit Un-conjugated EIA, WB Western blot analysis of PION in EL4 cell lysate with PION antibody at 0.25 μg/ml in (A) the absence and (B) the presence of blocking peptide. 0.1 mg Log in to see 6 to 8 Days
$401.50
Details
Human Rabbit Un-conjugated ICC, IHC (fro), IHC (p), ELISA, WB 100 μg Log in to see 9 to 11 Days
$422.40
Details
Human Rabbit Alkaline Phosphatase (AP) IHC, ELISA, WB   200 μL Log in to see 8 to 10 Days
$969.83
Details
Human Rabbit Biotin ELISA, WB   100 μg Log in to see 8 to 10 Days
$683.83
Details
Human Rabbit Un-conjugated ELISA   200 μL Log in to see 8 to 10 Days
$713.17
Details
Human Rabbit FITC WB   100 μg Log in to see 8 to 10 Days
$727.83
Details
Human Rabbit Un-conjugated WB   50 μg Log in to see 8 to 10 Days
$551.83
Details
Human Rabbit Un-conjugated ELISA   100 μg Log in to see 8 to 10 Days
$566.50
Details

PION Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
Human ,
,

, , , , , , , , , , , , ,
Mouse (Murine)
,

Rat (Rattus)


Top referenced anti-Pigeon Homolog (Drosophila) Antibodies

  1. Human Polyclonal PION Primary Antibody for EIA, IHC (p) - ABIN954149 : He, Luo, Li, Remmers, Netzer, Hendrick, Bettayeb, Flajolet, Gorelick, Wennogle, Greengard: Gamma-secretase activating protein is a therapeutic target for Alzheimer's disease. in Nature 2010 (PubMed)
    Show all 2 references for ABIN954149

More Antibodies against Pigeon Homolog (Drosophila) Interaction Partners

Human Pigeon Homolog (Drosophila) (PION) interaction partners

  1. GSAP cleavage via caspase-3 (show CASP3 Antibodies) is regulated and depend upon the availability of 5-Lipoxygenase (show ALOX5 Antibodies) in Alzheimer's disease.

  2. gamma-secretase activating protein (GSAP) and imatinib have roles in the regulation of gamma-secretase activity and amyloid-beta generation

  3. Protocols for recombinant bacterial expression and purification of potentially important protein GSAP are not successful in generating soluble forms of GSAP that contain well-ordered and homogeneous tertiary structure.

  4. Aberrant regulation of gamma-secretase activating protein expression plays a key role in acceleration of gamma-cleavage of beta-secretase-cleaved C-terminal fragment of amyloid precursor protein (show APP Antibodies) and accumulation of Abeta (show APP Antibodies) in AD brains

  5. A gamma-secretase activating protein (GSAP) that selectively increases amyloid-beta production via interactions with both gamma-secretase and its substrate, the amyloid precursor protein carboxy-terminal fragment.

Mouse (Murine) Pigeon Homolog (Drosophila) (PION) interaction partners

  1. GSAP cleavage via caspase-3 (show CASP3 Antibodies) is regulated and depend upon the availability of 5-Lipoxygenase (show ALOX5 Antibodies) in Alzheimer's disease.

  2. gamma-secretase activating protein (GSAP) and imatinib have roles in the regulation of gamma-secretase activity and amyloid-beta generation

  3. Study reports discovery of a novel gamma-secretase activating protein (GSAP) that selectively increases amyloid-beta production through interactions with gamma-secretase and its substrate, the amyloid precursor protein (show APP Antibodies) carboxy-terminal fragment.

Pigeon Homolog (Drosophila) (PION) Antigen Profile

Protein Summary

Accumulation of neurotoxic amyloid-beta is a major hallmark of Alzheimer disease (AD\; MIM 104300). Formation of amyloid-beta is catalyzed by gamma-secretase (see PSEN1\; MIM 104311), a protease with numerous substrates. PION, or GSAP, selectively increases amyloid-beta production through a mechanism involving its interaction with both gamma-secretase and its substrate, the amyloid-beta precursor protein (APP\; MIM 104760) C-terminal fragment (APP-CTF) (He et al., 2010

Gene names and symbols associated with PION

  • gamma-secretase activating protein (GSAP) antibody
  • gamma-secretase activating protein (Gsap) antibody
  • A530088I07Rik antibody
  • Pion antibody

Protein level used designations for PION

gamma-secretase-activating protein , pigeon homolog , protein pigeon homolog

GENE ID SPECIES
54103 Homo sapiens
212167 Mus musculus
311984 Rattus norvegicus
Selected quality suppliers for anti-Pigeon Homolog (Drosophila) (PION) Antibodies
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