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anti-Pinin, Desmosome Associated Protein (PNN) Antibodies

Transcriptional activator binding to the E-box 1 core sequence of the E-cadherin promoter gene\; the core-binding sequence is 5'CAGGTG-3'. Additionally we are shipping PNN Proteins (3) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
PNN 18949 O35691
PNN 5411 Q9H307
PNN 368070  
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Top anti-PNN Antibodies at antibodies-online.com

Showing 10 out of 73 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Chicken Rabbit Un-conjugated WB WB Suggested Anti-PNN Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:1562500Positive Control: HepG2 cell lysate Host: Rabbit  Target Name: PNN  Sample Tissue: 721_B  Antibody Dilution: 1.0 µg/mL PNN is strongly supported by BioGPS gene expression data to be expressed in Human 721_B cells 100 μL Log in to see 2 to 3 Days
$289.00
Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-PNN Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:12500Positive Control: 721_B cell lysate 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated IF, IHC (p), WB PNN Antibody (Center)  western blot analysis in NCI-H460 cell line lysates (35ug/lane).This demonstrates the PNN antibody detected the PNN protein (arrow). PNN Antibody (Center) immunohistochemistry analysis in formalin fixed and paraffin embedded human liver tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of PNN Antibody (Center) for immunohistochemistry.  Clinical relevance has not been evaluated. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated EIA, IF, IHC (p), WB Confocal immunofluorescent analysis of Pinin / PNN  Antibody  with NCI-H460 cell followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green). Actin filaments have been labeled with Alexa Fluor 555 phalloidin (red).DAPI was used to stain the cell nuclear (blue). Formalin fixed and paraffin embedded human liver tissue reacted with Pinin / PNN  Antibody  followed by peroxidase conjugation of the secondary antibody and DAB staining. 0.4 mL Log in to see 6 to 8 Days
$401.50
Details
Human Rabbit Un-conjugated ELISA, WB Western blot analysis of extracts from HT-29 cells, using PNN Antibody. The lane on the right is treated with the synthesized peptide. 100 μg Log in to see 2 to 3 Days
$302.50
Details
Human Rabbit Un-conjugated WB Host: Rabbit  Target Name: Pnn  Sample Tissue: Rat Thymus lysates  Antibody Dilution: 1.0 µg/mL 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Mouse Un-conjugated WB PNN monoclonal antibody (M01), clone 2B4 Western Blot analysis of PNN expression in PC-12. 0.1 mg Log in to see 8 to 11 Days
$450.00
Details
Human Rabbit Un-conjugated ELISA, WB 100 μL Log in to see 8 to 10 Days
$478.50
Details
Human Rabbit Un-conjugated WB 50 μg Log in to see 8 to 10 Days
$551.83
Details
Human Rabbit Un-conjugated WB 50 μg Log in to see 8 to 10 Days
$551.83
Details

PNN Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
Mouse (Murine) , ,


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Top referenced anti-PNN Antibodies

  1. Human Polyclonal PNN Primary Antibody for IF, IHC (p) - ABIN655502 : Alpatov, Shi, Munguba, Moghimi, Joo, Bungert, Sugrue: Corepressor CtBP and nuclear speckle protein Pnn/DRS differentially modulate transcription and splicing of the E-cadherin gene. in Molecular and cellular biology 2008 (PubMed)
    Show all 3 references for ABIN655502

  2. Human Polyclonal PNN Primary Antibody for EIA, IF - ABIN954147 : Matsuoka, Ballif, Smogorzewska, McDonald, Hurov, Luo, Bakalarski, Zhao, Solimini, Lerenthal, Shiloh, Gygi, Elledge: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage. in Science (New York, N.Y.) 2007 (PubMed)

  3. Human Polyclonal PNN Primary Antibody for ELISA, WB - ABIN1535175 : Shi, Ouyang, Sugrue: Characterization of the gene encoding pinin/DRS/memA and evidence for its potential tumor suppressor function. in Oncogene 2000 (PubMed)

More Antibodies against PNN Interaction Partners

Mouse (Murine) Pinin, Desmosome Associated Protein (PNN) interaction partners

  1. Pnn has an important role in alternative splicing of a specific subset of lncRNAs of the corneal epithelium.

  2. Pnn downregulation in skeletal muscle causes a muscular dystrophic phenotype associated with NEB (show NEB Antibodies) deficiency and the CCD (show RUNX2 Antibodies) domain is incapable of replacing full length Pnn in terms of functional capacity.

  3. Loss of Pnn induces apoptotic morphology in embryonic stem cells.

  4. The results suggest that astrocytes are unique among cell types of neuroblast origin in terms of expression Pinin protein.

  5. Pinin modulates expression of an intestinal homeobox (show PRRX1 Antibodies) gene, Cdx2 (show CDX2 Antibodies), and plays an essential role for small intestinal morphogenesis

  6. Spatial and temporal expression profile of pinin during mouse development.

  7. demonstrate abnormal activities of Tcf (show HNF4A Antibodies)/Lef transcription factors, and alterations in beta-catenin (show CTNNB1 Antibodies) level in multiple Pnn hypomorphic tissues

Human Pinin, Desmosome Associated Protein (PNN) interaction partners

  1. These data suggest that lowering of PNN levels in epithelial cells results in dramatic transformation in the number and composition of splicing variants and that PNN plays a crucial role in the selection of which RNA isoforms differentiating cells produce.

  2. PNN has an important role in alternative splicing of a specific subset of lncRNAs of the corneal epithelium.

  3. ESRP1 (show ESRP1 Antibodies) and PNN modulate alternative splicing of a specific subset of target genes, but not general splicing events, in HCET cells to maintain or enhance epithelial characteristics.

  4. Pinin functions as a splicing regulator (show PTBP2 Antibodies) which participates itself directly in splicing reaction or indirectly via other components of splicing machinery

  5. Pnn may participate, via its interaction with RNPS1 (show RNPS1 Antibodies), in mRNA metabolism in the nucleus, including mRNA splicing and export

  6. the interaction of Pnn with the corepressor CtBP1 (show CTBP1 Antibodies) may modulate repression of E-cadherin (show CDH1 Antibodies) transcription by CtBP1 (show CTBP1 Antibodies)

  7. Pnn may play a general role in the control of the cellular amount of family SR proteins through down-regulation of its own expression

  8. Corepressor CtBP (show CTBP2 Antibodies) and PNN/DRS differentially modulate transcription and splicing of the E-cadherin (show CDH1 Antibodies) gene.

Zebrafish Pinin, Desmosome Associated Protein (PNN) interaction partners

  1. pnn is essential for the maintenance of subsets of neural crest cells, and that in zebrafish proper cranial neural crest proliferation and differentiation are dependent on pnn expression.

PNN Antigen Profile

Protein Summary

Transcriptional activator binding to the E-box 1 core sequence of the E-cadherin promoter gene\; the core-binding sequence is 5'CAGGTG-3'. Capable of reversing CTBP1-mediated transcription repression. Component of a splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of a few core proteins and several more peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Participates in the regulation of alternative pre-mRNA splicing. Associates to spliced mRNA within 60 nt upstream of the 5'-splice sites. Involved in the establishment and maintenance of epithelia cell-cell adhesion (By similarity).

Gene names and symbols associated with PNN

  • pinin-like (LOC100060952) antibody
  • pinin, desmosome associated protein (PNN) antibody
  • pinin, desmosome associated protein (pnn) antibody
  • pinin, desmosome associated protein (LOC100227753) antibody
  • Pinin (Pnn) antibody
  • PININ protein (pinin) antibody
  • pinin (Pnn) antibody
  • pinin, desmosome associated protein (Pnn) antibody
  • AU045199 antibody
  • CG8383 antibody
  • D12Ertd512e antibody
  • DKFZp459I0427 antibody
  • Dmel\\CG8383 antibody
  • dPnn antibody
  • DRS antibody
  • DRSP antibody
  • memA antibody
  • MGC88923 antibody
  • MGC127754 antibody
  • Pinin antibody
  • pnn antibody
  • SDK3 antibody
  • wu:fb24d03 antibody

Protein level used designations for PNN

pinin, desmosome associated protein , neutrophil protein , CG8383-PA , CG8383-PB , Pnn-PA , Pnn-PB , pinin , PININ protein , 140 kDa nuclear and cell adhesion-related phosphoprotein , SR-like protein , desmosome-associated protein , domain-rich serine protein , melanoma metastasis clone A protein , nuclear protein SDK3 , fb24d03

GENE ID SPECIES
100060952 Equus caballus
282700 Bos taurus
397635 Sus scrofa
448224 Xenopus (Silurana) tropicalis
452875 Pan troglodytes
100173662 Pongo abelii
100227753 Taeniopygia guttata
100606214 Nomascus leucogenys
41185 Drosophila melanogaster
100380709 Salmo salar
18949 Mus musculus
5411 Homo sapiens
368070 Rattus norvegicus
407733 Danio rerio
423338 Gallus gallus
403907 Canis lupus familiaris
100296970 Bos taurus
100526149 Sus scrofa
100443066 Pongo abelii
Selected quality suppliers for anti-PNN (PNN) Antibodies
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