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Pinin, Desmosome Associated Protein Proteins (PNN)

Transcriptional activator binding to the E-box 1 core sequence of the E-cadherin promoter gene\; the core-binding sequence is 5'CAGGTG-3'. Additionally we are shipping PNN Antibodies (77) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
PNN 18949 O35691
PNN 5411 Q9H307
Rat PNN PNN 368070  
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Top PNN Proteins at antibodies-online.com

Showing 3 out of 3 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details

PNN Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human ,
,

More Proteins for Pinin, Desmosome Associated Protein (PNN) Interaction Partners

Mouse (Murine) Pinin, Desmosome Associated Protein (PNN) interaction partners

  1. Pnn has an important role in alternative splicing of a specific subset of lncRNAs of the corneal epithelium.

  2. Pnn downregulation in skeletal muscle causes a muscular dystrophic phenotype associated with NEB deficiency and the CCD (show RUNX2 Proteins) domain is incapable of replacing full length Pnn in terms of functional capacity.

  3. Loss of Pnn induces apoptotic morphology in embryonic stem cells.

  4. The results suggest that astrocytes are unique among cell types of neuroblast origin in terms of expression Pinin protein.

  5. Pinin modulates expression of an intestinal homeobox (show PRRX1 Proteins) gene, Cdx2 (show CDX2 Proteins), and plays an essential role for small intestinal morphogenesis

  6. Spatial and temporal expression profile of pinin during mouse development.

  7. demonstrate abnormal activities of Tcf (show HNF4A Proteins)/Lef transcription factors, and alterations in beta-catenin (show CTNNB1 Proteins) level in multiple Pnn hypomorphic tissues

Human Pinin, Desmosome Associated Protein (PNN) interaction partners

  1. These data suggest that lowering of PNN levels in epithelial cells results in dramatic transformation in the number and composition of splicing variants and that PNN plays a crucial role in the selection of which RNA isoforms differentiating cells produce.

  2. PNN has an important role in alternative splicing of a specific subset of lncRNAs of the corneal epithelium.

  3. ESRP1 (show ESRP1 Proteins) and PNN modulate alternative splicing of a specific subset of target genes, but not general splicing events, in HCET cells to maintain or enhance epithelial characteristics.

  4. Pinin functions as a splicing regulator (show PTBP2 Proteins) which participates itself directly in splicing reaction or indirectly via other components of splicing machinery

  5. Pnn may participate, via its interaction with RNPS1 (show RNPS1 Proteins), in mRNA metabolism in the nucleus, including mRNA splicing and export

  6. the interaction of Pnn with the corepressor CtBP1 (show CTBP1 Proteins) may modulate repression of E-cadherin (show CDH1 Proteins) transcription by CtBP1 (show CTBP1 Proteins)

  7. Pnn may play a general role in the control of the cellular amount of family SR proteins through down-regulation of its own expression

  8. Corepressor CtBP (show CTBP2 Proteins) and PNN/DRS differentially modulate transcription and splicing of the E-cadherin (show CDH1 Proteins) gene.

Zebrafish Pinin, Desmosome Associated Protein (PNN) interaction partners

  1. pnn is essential for the maintenance of subsets of neural crest cells, and that in zebrafish proper cranial neural crest proliferation and differentiation are dependent on pnn expression.

PNN Protein Profile

Protein Summary

Transcriptional activator binding to the E-box 1 core sequence of the E-cadherin promoter gene\; the core-binding sequence is 5'CAGGTG-3'. Capable of reversing CTBP1-mediated transcription repression. Component of a splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of a few core proteins and several more peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Participates in the regulation of alternative pre-mRNA splicing. Associates to spliced mRNA within 60 nt upstream of the 5'-splice sites. Involved in the establishment and maintenance of epithelia cell-cell adhesion (By similarity).

Gene names and symbols associated with PNN

  • pinin-like (LOC100060952)
  • pinin, desmosome associated protein (PNN)
  • pinin, desmosome associated protein (pnn)
  • pinin, desmosome associated protein (LOC100227753)
  • Pinin (Pnn)
  • PININ protein (pinin)
  • pinin (Pnn)
  • pinin, desmosome associated protein (Pnn)
  • AU045199 protein
  • CG8383 protein
  • D12Ertd512e protein
  • DKFZp459I0427 protein
  • Dmel\\CG8383 protein
  • dPnn protein
  • DRS protein
  • DRSP protein
  • memA protein
  • MGC88923 protein
  • MGC127754 protein
  • Pinin protein
  • pnn protein
  • SDK3 protein
  • wu:fb24d03 protein

Protein level used designations for PNN

pinin, desmosome associated protein , neutrophil protein , CG8383-PA , CG8383-PB , Pnn-PA , Pnn-PB , pinin , PININ protein , 140 kDa nuclear and cell adhesion-related phosphoprotein , SR-like protein , desmosome-associated protein , domain-rich serine protein , melanoma metastasis clone A protein , nuclear protein SDK3 , fb24d03

GENE ID SPECIES
100060952 Equus caballus
282700 Bos taurus
397635 Sus scrofa
448224 Xenopus (Silurana) tropicalis
452875 Pan troglodytes
100173662 Pongo abelii
100227753 Taeniopygia guttata
100606214 Nomascus leucogenys
41185 Drosophila melanogaster
100380709 Salmo salar
18949 Mus musculus
5411 Homo sapiens
368070 Rattus norvegicus
407733 Danio rerio
423338 Gallus gallus
403907 Canis lupus familiaris
100296970 Bos taurus
100526149 Sus scrofa
100443066 Pongo abelii
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