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Pitrilysin Metallopeptidase 1 Proteins (PITRM1)

ATP-independent protease that degrades mitochondrial transit peptides after their cleavage. Additionally we are shipping PITRM1 Antibodies (50) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
PITRM1 307081  
PITRM1 69617 Q8K411
PITRM1 10531 Q5JRX3
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Top PITRM1 Proteins at antibodies-online.com

Showing 8 out of 8 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 49 to 54 Days
$13,567.94
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 49 to 54 Days
$13,567.94
Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 11 to 13 Days
$792.00
Details
HOST_Escherichia coli (E. coli) Rat His tag 100 μg Log in to see 11 to 13 Days
$862.40
Details
HOST_Wheat germ Human GST tag 2 μg Log in to see 9 Days
$333.33
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 9 to 19 Days
$967.75
Details
HOST_Escherichia coli (E. coli) Rat Un-conjugated   100 μg Log in to see 9 to 19 Days
$1,030.69
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

PITRM1 Proteins by Origin and Source

Origin Expressed in Conjugate
Rat (Rattus)

Mouse (Murine)

Human , ,
,

More Proteins for Pitrilysin Metallopeptidase 1 (PITRM1) Interaction Partners

Mouse (Murine) Pitrilysin Metallopeptidase 1 (PITRM1) interaction partners

  1. results suggest that pitrilysin regulates islet amyloid polypeptide (show IAPP Proteins) in beta cells and suggest the presence of an intramitochondrial pool of islet amyloid polypeptide (show IAPP Proteins) involved in beta-cell apoptosis.

  2. Pitrm1 is expressed in Pax3 (show PAX3 Proteins)-expressing myoblast progenitors in the limb, the dermomyotome, and developing muscles of the face and torso.

Human Pitrilysin Metallopeptidase 1 (PITRM1) interaction partners

  1. Data show that the hPreP presequence only targets GFP to the matrix of mammalian and yeast mitochondria.

  2. This study demonstrated decreased proteolytic activity of the mitochondrial amyloid-beta degrading enzyme, PreP peptidasome, in Alzheimer's disease brain mitochondria.

  3. our data suggest that genetic variation in the hPreP gene PITRM1 may potentially contribute to mitochondrial dysfunctions

  4. The substrate specificity of the mitochondrial metallopeptidase proteinase 1 (MP1) was investigated and its mitochondrial targeting signal identified.

  5. Data revealed that six polymorphisms of F10, PITRM1, PCSK2, JPH3, MYO7B, and AKAP12 were related (P<0.05) to the prevalence of chronic kidney disease.

PITRM1 Protein Profile

Protein Summary

ATP-independent protease that degrades mitochondrial transit peptides after their cleavage. Also degrades other unstructured peptides. Specific for peptides in the range of 10 to 65 residues. Able to degrade amyloid beta A4 (APP) protein when it accumulates in mitochondrion, suggesting a link with Alzheimer disease. Shows a preference for cleavage after small polar residues and before basic residues, but without any positional preference.

Gene names and symbols associated with PITRM1

  • pitrilysin metallopeptidase 1 (Pitrm1)
  • DKFZP468C1910 protein (DKFZP468C1910)
  • pitrilysin metallepetidase 1 (Pitrm1)
  • pitrilysin metallopeptidase 1 (PITRM1)
  • pitrilysin metallopeptidase 1 (pitrm1)
  • pitrilysin metalloproteinase 1 (pitrm1)
  • 2310012C15Rik protein
  • AA410010 protein
  • mKIAA1104 protein
  • MP-1 protein
  • MP1 protein
  • Ntup1 protein
  • PITRM1 protein
  • PreP protein
  • wu:fa03d09 protein
  • zgc:55469 protein

Protein level used designations for PITRM1

pitrilysin metallepetidase 1 , pitrilysin metalloprotease 1 , presequence protease, mitochondrial , Pitrilysin metalloproteinase 1 , nuclear transplantation upregulated protein 1 , pitrilysin metalloproteinase 1 , PreP peptidasome , metalloprotease 1 (pitrilysin family)

GENE ID SPECIES
307081 Rattus norvegicus
100189669 Pongo abelii
69617 Mus musculus
10531 Homo sapiens
379672 Xenopus laevis
406808 Danio rerio
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