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ATP-independent protease that degrades mitochondrial transit peptides after their cleavage. Additionally we are shipping PITRM1 Antibodies (49) and and many more products for this protein.
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results suggest that pitrilysin regulates islet amyloid polypeptide (show IAPP Proteins) in beta cells and suggest the presence of an intramitochondrial pool of islet amyloid polypeptide (show IAPP Proteins) involved in beta-cell apoptosis.
Pitrm1 is expressed in Pax3 (show PAX3 Proteins)-expressing myoblast progenitors in the limb, the dermomyotome, and developing muscles of the face and torso.
The authors identified two siblings carrying a homozygous PITRM1 missense mutation (c.548G>A, p.Arg183Gln) associated with an autosomal recessive, slowly progressive syndrome characterised by mental retardation, spinocerebellar ataxia (show USP14 Proteins), cognitive decline and psychosis.
Data show that the hPreP presequence only targets GFP to the matrix of mammalian and yeast mitochondria.
This study demonstrated decreased proteolytic activity of the mitochondrial amyloid-beta degrading enzyme, PreP peptidasome, in Alzheimer's disease brain mitochondria.
our data suggest that genetic variation in the hPreP gene PITRM1 may potentially contribute to mitochondrial dysfunctions
The substrate specificity of the mitochondrial metallopeptidase proteinase 1 (MP1) was investigated and its mitochondrial targeting signal identified.
Data revealed that six polymorphisms of F10, PITRM1, PCSK2, JPH3, MYO7B, and AKAP12 were related (P<0.05) to the prevalence of chronic kidney disease.
ATP-independent protease that degrades mitochondrial transit peptides after their cleavage. Also degrades other unstructured peptides. Specific for peptides in the range of 10 to 65 residues. Able to degrade amyloid beta A4 (APP) protein when it accumulates in mitochondrion, suggesting a link with Alzheimer disease. Shows a preference for cleavage after small polar residues and before basic residues, but without any positional preference.
pitrilysin metallepetidase 1
, pitrilysin metalloprotease 1
, presequence protease, mitochondrial
, Pitrilysin metalloproteinase 1
, nuclear transplantation upregulated protein 1
, pitrilysin metalloproteinase 1
, PreP peptidasome
, metalloprotease 1 (pitrilysin family)