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PITX3 encodes a member of the RIEG/PITX homeobox family, which is in the bicoid class of homeodomain proteins. Additionally we are shipping Pituitary Homeobox 3 Antibodies (42) and Pituitary Homeobox 3 Proteins (12) and many more products for this protein.
Study showed that PITX3 and PITX2 (show PITX2 ELISA Kits) were hypermethylated in prostate carcinomas (PCa (show FLVCR1 ELISA Kits)) and significantly associated with established clinicopathologic parameters characteristic of PCa (show FLVCR1 ELISA Kits).
These findings suggest that p.A203fs in PITX3 is the cause of cataracts in the recruited family.
PITX3 variants rs3758549 and rs4919621 are not associated with ET in Chinese Han population.
novel PITX3 mutation c.573del, p.(Ser192Alafs*117), was identified in heterozygous state in a Belgo-Romanian family with a similar phenotype
our data demonstrate that key midbrain dopamine regulators (Nurr1 (show NR4A2 ELISA Kits), Pitx3, and Lmx1a (show LMX1A ELISA Kits)) play overlapping as well as distinct roles during neurogenesis and neurotransmitter phenotype determination of mDA neurons
Mutations in PITX3 are not a common cause or a risk factor for multisystem atrophy and progressive supranuclear palsy in the Polish population.
Presence of the rs4919621 allele A in PITX3 significantly increases the risk of Parkinson's disease (PD) patients in a Caucasian population, while rs2281983 allele C and rs4919621 allele A were both risk factors in early onset PD.
This study provided that NURR1 (show NR4A2 ELISA Kits) and PITX3 gene expression is decreased in the peripheral blood lymphocytes of Chinese patients with Parkinson's disease patients.
novel synonymous SNP in PITX3 gene may contribute to PD risk in the Chinese population.
Deletion of PITX3 is associated with aggressive neurobehavioral phenotype in Smith-Magenis Syndrome.
In Xenopus, pitx3 appears to inhibit the rotation of presomitic cell cohorts and to be necessary to the bilaterally symmetric expression of pitx2 (show PITX2 ELISA Kits) in somites.
Microarray-based identification of Pitx3 targets during Xenopus embryogenesis.
expression of Pitx3 in the presumptive lens ectoderm is critical for retina development
in absence of En1 (show EN1 ELISA Kits) and Pitx3, only a limited number of Mesodiencephalic dopaminergic neurons are present in mouse embryo.
Pitx3 is specifically required for DA-related function and, if impaired, Pitx3 could contribute during the pathogenesis of Parkinson's disease.
the sonic hedgehog (show SHH ELISA Kits) signaling pathway is both necessary and sufficient for the induction of ectopic PITX3 expression in chick mesencephalon downstream of WNT9A (show WNT9A ELISA Kits)-induced LMX1a (show LMX1A ELISA Kits) transcription.
microphthalmos/aphakia inPITX3 nonsense mutant is caused by the expression of truncated PITX3, resulting in the abnormal expression of downstream targets and lens fiber proteins.
Pitx3 binds to an evolutionary conserved bicoid-binding site on the 5'-upstream region of Foxe3 (show FOXE3 ELISA Kits). Pitx3 binding to 5'-upstream region of Foxe3 (show FOXE3 ELISA Kits) increased transcriptional activity significantly in a cell-based reporter assay.
During fetal myogenesis, Pitx2 (show PITX2 ELISA Kits)/3 control this redox state through the regulation of Nrf1 (show NRF1 ELISA Kits) and of antioxidant pathways.
Pitx3 overexpressing mouse significantly affects the gene expression of midbrain dopamine neurons. Motor coordination and locomotion activities are significantly affected in mice overexpressing Pitx3 mice.
Primary fetal neurobehavioral deficit of the Pitx3 mutation is akinesia related to nigrostriatal damage.
Two crucial mediators of mesodiencephalic dopaminergic neuronal development, En1 (show EN1 ELISA Kits) and Pitx3, interact in dopaminergic subset specification.
a novel link between Pitx3 function and the selective pattern of midbrain dopaminergic neurons cell loss observed in Parkinson's disease.
pitx3 expression in the primordia of the pituitary, lens, olfactory mucosa, and cranial ganglia is modulated by hedgehog (show SHH ELISA Kits) and nodal proteins' signaling.
results demonstrate zebrafish pitx3 represents a true ortholog of the human PITX3 gene and the general function of the Pitx3 protein in lens development is conserved between mammals and the teleost fish
Data demonstrate that Foxe3 (show FOXE3 ELISA Kits) is necessary for lens development in zebrafish and that foxe3 (show FOXE3 ELISA Kits) lies genetically downstream of pitx3 in a zebrafish lens development pathway.
while lmx1b (show LMX1B ELISA Kits) paralogues may contribute to the generation of diencephalic dopaminergic precursors. Conversely, knock-down of pitx3 does not specifically affect any diencephalic dopamine cluster
This gene encodes a member of the RIEG/PITX homeobox family, which is in the bicoid class of homeodomain proteins. Members of this family act as transcription factors. This protein is involved in lens formation during eye development. Mutations of this gene have been associated with anterior segment mesenchymal dysgenesis and congenital cataracts.
pituitary homeobox 3
, homeobox protein PITX3
, paired-like homeodomain transcription factor 3
, homeobox protein PTX3
, homeodomain transcription factor Pitx-3
, Pituitary homeobox 3 (Homeobox protein PITX3)
, bicoid-like homeodomain transcription factor 3
, bicoid-like homeodomain transcription factor Pitx3